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Integrative biological analysis for neuropsychopharmacology

Emmett, Mark R; Kroes, Roger A; Moskal, Joseph R; Conrad, Charles A.; Priebe, Waldemar; Laezza, Fernanda; Meyer-Baese, Anke and Nilsson, Carol L LU (2014) In Neuropsychopharmacology 39(1). p.5-23
Abstract

Although advances in psychotherapy have been made in recent years, drug discovery for brain diseases such as schizophrenia and mood disorders has stagnated. The need for new biomarkers and validated therapeutic targets in the field of neuropsychopharmacology is widely unmet. The brain is the most complex part of human anatomy from the standpoint of number and types of cells, their interconnections, and circuitry. To better meet patient needs, improved methods to approach brain studies by understanding functional networks that interact with the genome are being developed. The integrated biological approaches--proteomics, transcriptomics, metabolomics, and glycomics--have a strong record in several areas of biomedicine, including... (More)

Although advances in psychotherapy have been made in recent years, drug discovery for brain diseases such as schizophrenia and mood disorders has stagnated. The need for new biomarkers and validated therapeutic targets in the field of neuropsychopharmacology is widely unmet. The brain is the most complex part of human anatomy from the standpoint of number and types of cells, their interconnections, and circuitry. To better meet patient needs, improved methods to approach brain studies by understanding functional networks that interact with the genome are being developed. The integrated biological approaches--proteomics, transcriptomics, metabolomics, and glycomics--have a strong record in several areas of biomedicine, including neurochemistry and neuro-oncology. Published applications of an integrated approach to projects of neurological, psychiatric, and pharmacological natures are still few but show promise to provide deep biological knowledge derived from cells, animal models, and clinical materials. Future studies that yield insights based on integrated analyses promise to deliver new therapeutic targets and biomarkers for personalized medicine.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Biomarkers, Gene Expression Profiling, Glycomics, Humans, Metabolomics, Models, Biological, Neuropharmacology, Proteomics, Psychopharmacology, Systems Biology, Journal Article, Research Support, N.I.H., Extramural, Review
in
Neuropsychopharmacology
volume
39
issue
1
pages
19 pages
publisher
Elsevier
external identifiers
  • scopus:84890501825
ISSN
1740-634X
DOI
10.1038/npp.2013.156
language
English
LU publication?
no
id
657e31c8-417d-4fb2-9def-811fe65d6ef9
date added to LUP
2017-05-16 10:27:56
date last changed
2017-11-14 09:56:13
@article{657e31c8-417d-4fb2-9def-811fe65d6ef9,
  abstract     = {<p>Although advances in psychotherapy have been made in recent years, drug discovery for brain diseases such as schizophrenia and mood disorders has stagnated. The need for new biomarkers and validated therapeutic targets in the field of neuropsychopharmacology is widely unmet. The brain is the most complex part of human anatomy from the standpoint of number and types of cells, their interconnections, and circuitry. To better meet patient needs, improved methods to approach brain studies by understanding functional networks that interact with the genome are being developed. The integrated biological approaches--proteomics, transcriptomics, metabolomics, and glycomics--have a strong record in several areas of biomedicine, including neurochemistry and neuro-oncology. Published applications of an integrated approach to projects of neurological, psychiatric, and pharmacological natures are still few but show promise to provide deep biological knowledge derived from cells, animal models, and clinical materials. Future studies that yield insights based on integrated analyses promise to deliver new therapeutic targets and biomarkers for personalized medicine.</p>},
  author       = {Emmett, Mark R and Kroes, Roger A and Moskal, Joseph R and Conrad, Charles A. and Priebe, Waldemar and Laezza, Fernanda and Meyer-Baese, Anke and Nilsson, Carol L},
  issn         = {1740-634X},
  keyword      = {Animals,Biomarkers,Gene Expression Profiling,Glycomics,Humans,Metabolomics,Models, Biological,Neuropharmacology,Proteomics,Psychopharmacology,Systems Biology,Journal Article,Research Support, N.I.H., Extramural,Review},
  language     = {eng},
  number       = {1},
  pages        = {5--23},
  publisher    = {Elsevier},
  series       = {Neuropsychopharmacology},
  title        = {Integrative biological analysis for neuropsychopharmacology},
  url          = {http://dx.doi.org/10.1038/npp.2013.156},
  volume       = {39},
  year         = {2014},
}