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Cortisone fails to affect levels of islet cell surface antibodies and incidence of diabetes in the BB rat

Dyrberg, T. ; King, J. ; Lernmark LU orcid and Martin, J. M. (1985) In Endocrinology 116(1). p.47-50
Abstract

Cortisone acetate (250 µg/kg·day) was given by im injections to 40 21-day-old diabetes-prone BB rats. The animals were followed longitudinally to determine islet cell surface antibodies (ICSA), as an expression of an abnormal immune reaction against the pancreatic islet cells and plasma glucose to estimate the degree of metabolic control. ICSA were detected 10-150 days before the diagnosis of diabetes. In the cortisone-treated group the diabetic rats showed significantly higher ICSA values compared to the nondiabetic ones, both in frequency of positive tests (P < 0.05) and in mean binding values (P < 0.02). In the control group, no difference in ICSA levels were seen between diabetic and nondiabetic rats. The cortisone regimen... (More)

Cortisone acetate (250 µg/kg·day) was given by im injections to 40 21-day-old diabetes-prone BB rats. The animals were followed longitudinally to determine islet cell surface antibodies (ICSA), as an expression of an abnormal immune reaction against the pancreatic islet cells and plasma glucose to estimate the degree of metabolic control. ICSA were detected 10-150 days before the diagnosis of diabetes. In the cortisone-treated group the diabetic rats showed significantly higher ICSA values compared to the nondiabetic ones, both in frequency of positive tests (P < 0.05) and in mean binding values (P < 0.02). In the control group, no difference in ICSA levels were seen between diabetic and nondiabetic rats. The cortisone regimen also failed to influence the degree of insulitis, commonly associated with diabetes in these rats. These experiments in well defined animals which spontaneously develop diabetes do not support the use of low dose cortisone treatment in attempts to improve or prevent insulin-dependent diabetes in human subjects.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
in
Endocrinology
volume
116
issue
1
pages
4 pages
publisher
Oxford University Press
external identifiers
  • scopus:0021927608
  • pmid:3880546
ISSN
0013-7227
DOI
10.1210/endo-116-1-47
language
English
LU publication?
no
id
658e7e54-184f-40cf-ac7c-5647e1b448a2
date added to LUP
2019-09-16 12:38:38
date last changed
2024-03-13 08:08:50
@article{658e7e54-184f-40cf-ac7c-5647e1b448a2,
  abstract     = {{<p>Cortisone acetate (250 µg/kg·day) was given by im injections to 40 21-day-old diabetes-prone BB rats. The animals were followed longitudinally to determine islet cell surface antibodies (ICSA), as an expression of an abnormal immune reaction against the pancreatic islet cells and plasma glucose to estimate the degree of metabolic control. ICSA were detected 10-150 days before the diagnosis of diabetes. In the cortisone-treated group the diabetic rats showed significantly higher ICSA values compared to the nondiabetic ones, both in frequency of positive tests (P &lt; 0.05) and in mean binding values (P &lt; 0.02). In the control group, no difference in ICSA levels were seen between diabetic and nondiabetic rats. The cortisone regimen also failed to influence the degree of insulitis, commonly associated with diabetes in these rats. These experiments in well defined animals which spontaneously develop diabetes do not support the use of low dose cortisone treatment in attempts to improve or prevent insulin-dependent diabetes in human subjects.</p>}},
  author       = {{Dyrberg, T. and King, J. and Lernmark and Martin, J. M.}},
  issn         = {{0013-7227}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{47--50}},
  publisher    = {{Oxford University Press}},
  series       = {{Endocrinology}},
  title        = {{Cortisone fails to affect levels of islet cell surface antibodies and incidence of diabetes in the BB rat}},
  url          = {{http://dx.doi.org/10.1210/endo-116-1-47}},
  doi          = {{10.1210/endo-116-1-47}},
  volume       = {{116}},
  year         = {{1985}},
}