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Evaluation of osmotic effects on coated pellets using a mechanistic model

Marucci, Mariagrazia LU ; Ragnarsson, Gert and Axelsson, Anders LU (2007) In International Journal of Pharmaceutics 336(1). p.67-74
Abstract
The aim of this study was to develop a simple experimental methodology and to develop a mechanistic model to characterize the release mechanism from pellets developing cracks during the release process with special focus on osmotic effects. The release of remoxipride from pellets coated with an ethyl cellulose film was chosen as a case study. Dose release experiments at different bulk osmotic pressures revealed that the release process was mainly osmotically driven. The model was used to calculate the solvent permeability of the coating, 1.1 x 10(-10) m(2) h(-1) MPa-1 The model was validated by release experiments using similar pellets having different coating thicknesses. The effective diffusion coefficient of remoxipride in the coating... (More)
The aim of this study was to develop a simple experimental methodology and to develop a mechanistic model to characterize the release mechanism from pellets developing cracks during the release process with special focus on osmotic effects. The release of remoxipride from pellets coated with an ethyl cellulose film was chosen as a case study. Dose release experiments at different bulk osmotic pressures revealed that the release process was mainly osmotically driven. The model was used to calculate the solvent permeability of the coating, 1.1 x 10(-10) m(2) h(-1) MPa-1 The model was validated by release experiments using similar pellets having different coating thicknesses. The effective diffusion coefficient of remoxipride in the coating was also calculated and found to be 1.7 x 10(-1) m(2) h(-1). A series of experiments was performed in which the osmotic pressure of the receiving solution was changed during the experiment. From the results of these experiments, the area of the cracks in the film, formed by the hydrostatic pressure built up inside the pellets, was estimated to be 3.5 x 10(-5) m(2)/m(2) coating. It could also be deduced that the solvent permeability of the coating film was affected by swelling in the same way at different osmotic pressures. (C) 2006 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ethyl cellulose, pellets, diffusion, osmotic pumping, release mechanism, modelling
in
International Journal of Pharmaceutics
volume
336
issue
1
pages
67 - 74
publisher
Elsevier
external identifiers
  • wos:000246491100008
  • scopus:34047263187
ISSN
1873-3476
DOI
10.1016/j.ijpharm.2006.11.032
language
English
LU publication?
yes
id
34bfe36f-d83d-45a3-bae7-655fc7b98f29 (old id 659509)
date added to LUP
2007-12-14 16:49:15
date last changed
2017-09-03 03:45:24
@article{34bfe36f-d83d-45a3-bae7-655fc7b98f29,
  abstract     = {The aim of this study was to develop a simple experimental methodology and to develop a mechanistic model to characterize the release mechanism from pellets developing cracks during the release process with special focus on osmotic effects. The release of remoxipride from pellets coated with an ethyl cellulose film was chosen as a case study. Dose release experiments at different bulk osmotic pressures revealed that the release process was mainly osmotically driven. The model was used to calculate the solvent permeability of the coating, 1.1 x 10(-10) m(2) h(-1) MPa-1 The model was validated by release experiments using similar pellets having different coating thicknesses. The effective diffusion coefficient of remoxipride in the coating was also calculated and found to be 1.7 x 10(-1) m(2) h(-1). A series of experiments was performed in which the osmotic pressure of the receiving solution was changed during the experiment. From the results of these experiments, the area of the cracks in the film, formed by the hydrostatic pressure built up inside the pellets, was estimated to be 3.5 x 10(-5) m(2)/m(2) coating. It could also be deduced that the solvent permeability of the coating film was affected by swelling in the same way at different osmotic pressures. (C) 2006 Elsevier B.V. All rights reserved.},
  author       = {Marucci, Mariagrazia and Ragnarsson, Gert and Axelsson, Anders},
  issn         = {1873-3476},
  keyword      = {ethyl cellulose,pellets,diffusion,osmotic pumping,release mechanism,modelling},
  language     = {eng},
  number       = {1},
  pages        = {67--74},
  publisher    = {Elsevier},
  series       = {International Journal of Pharmaceutics},
  title        = {Evaluation of osmotic effects on coated pellets using a mechanistic model},
  url          = {http://dx.doi.org/10.1016/j.ijpharm.2006.11.032},
  volume       = {336},
  year         = {2007},
}