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Mutations in fusA associated with posttherapy fusidic acid resistance in Clostridium difficile

Noren, T.; Akerlund, T.; Wullt, Marlene LU ; Burman, L. G. and Unemo, M. (2007) In Antimicrobial Agents and Chemotherapy 51(5). p.1840-1843
Abstract
In silico, we identified fusA (2,067 bp) in Clostridium difficile 630. Sequencing of fusA in posttherapy fusidic acid-resistant C. difficile isolates from 12 patients with C. difficile-associated diarrhea (CDAD) identified fusA mutations, one or two nonsynonymous substitutions, or in one case a deletion of one codon associated with resistance. Five of these mutations have previously been described in fusA of fusidic acid-resistant Staphylococcus aureus, but seven were novel fusA mutations. Fusidic acid monotherapy for CDAD seemed to rapidly select conserved resistant mutants.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Antimicrobial Agents and Chemotherapy
volume
51
issue
5
pages
1840 - 1843
publisher
American Society for Microbiology
external identifiers
  • wos:000246541500038
  • scopus:34248367707
ISSN
1098-6596
DOI
10.1128/AAC.01283-06
language
English
LU publication?
yes
id
1fe0b184-a5b6-415a-ac27-7d4bf16dfb92 (old id 659722)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17307985&dopt=Abstract
date added to LUP
2007-12-14 10:49:29
date last changed
2017-07-09 04:27:58
@article{1fe0b184-a5b6-415a-ac27-7d4bf16dfb92,
  abstract     = {In silico, we identified fusA (2,067 bp) in Clostridium difficile 630. Sequencing of fusA in posttherapy fusidic acid-resistant C. difficile isolates from 12 patients with C. difficile-associated diarrhea (CDAD) identified fusA mutations, one or two nonsynonymous substitutions, or in one case a deletion of one codon associated with resistance. Five of these mutations have previously been described in fusA of fusidic acid-resistant Staphylococcus aureus, but seven were novel fusA mutations. Fusidic acid monotherapy for CDAD seemed to rapidly select conserved resistant mutants.},
  author       = {Noren, T. and Akerlund, T. and Wullt, Marlene and Burman, L. G. and Unemo, M.},
  issn         = {1098-6596},
  language     = {eng},
  number       = {5},
  pages        = {1840--1843},
  publisher    = {American Society for Microbiology},
  series       = {Antimicrobial Agents and Chemotherapy},
  title        = {Mutations in fusA associated with posttherapy fusidic acid resistance in Clostridium difficile},
  url          = {http://dx.doi.org/10.1128/AAC.01283-06},
  volume       = {51},
  year         = {2007},
}