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Weak telomerase activity in malignant cells in metastatic serous effusions - Correlation to short survival time

Zendehrokh, Nooreldin LU ; Franzen, Lina and Dejmek, Annika LU (2007) In Acta Cytologica 51(3). p.412-416
Abstract
Objective The purpose of this study was to evaluate whether the intensity of telomerase activity measured on the cellular level in effusions correllates to survival time in cases of metastatic spread to the serous cavities. Study Design Telomere repeat amplification protocol (TRAP) in situ was applied to 46 effusions containing metastatic cancer cells. Results Weak telomerase activity in tumor cells was seen in 7 cases, and moderate or strong activity in 39 cases. The intensity of the enzyme activity correlated significantly to survival (Kaplan-Meier survival analysis), the median survival time being 18 days for patients with weakly positive tumors and 100 days for patients with moderately or strongly positive tumors (Kruskal-Wallis test,... (More)
Objective The purpose of this study was to evaluate whether the intensity of telomerase activity measured on the cellular level in effusions correllates to survival time in cases of metastatic spread to the serous cavities. Study Design Telomere repeat amplification protocol (TRAP) in situ was applied to 46 effusions containing metastatic cancer cells. Results Weak telomerase activity in tumor cells was seen in 7 cases, and moderate or strong activity in 39 cases. The intensity of the enzyme activity correlated significantly to survival (Kaplan-Meier survival analysis), the median survival time being 18 days for patients with weakly positive tumors and 100 days for patients with moderately or strongly positive tumors (Kruskal-Wallis test, p=0.021). Conclusion The strong relationship between telomerase activity in tumor cells in effusions and survival time has never been described before. Determination of telomerase activity on the cellular level provides a way to identify a subgroup of patients with a high probability of short survival. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
telomere repeat amplification, telomerase, carcinoma, effusions, protocol, survival
in
Acta Cytologica
volume
51
issue
3
pages
412 - 416
publisher
Science Printers and Publishers
external identifiers
  • wos:000246495600009
  • scopus:34248652430
ISSN
0001-5547
language
English
LU publication?
yes
id
b22c2d6e-3f8f-4472-9df4-d69f2132f2aa (old id 659736)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez
date added to LUP
2007-12-19 11:50:20
date last changed
2017-01-01 07:26:17
@article{b22c2d6e-3f8f-4472-9df4-d69f2132f2aa,
  abstract     = {Objective The purpose of this study was to evaluate whether the intensity of telomerase activity measured on the cellular level in effusions correllates to survival time in cases of metastatic spread to the serous cavities. Study Design Telomere repeat amplification protocol (TRAP) in situ was applied to 46 effusions containing metastatic cancer cells. Results Weak telomerase activity in tumor cells was seen in 7 cases, and moderate or strong activity in 39 cases. The intensity of the enzyme activity correlated significantly to survival (Kaplan-Meier survival analysis), the median survival time being 18 days for patients with weakly positive tumors and 100 days for patients with moderately or strongly positive tumors (Kruskal-Wallis test, p=0.021). Conclusion The strong relationship between telomerase activity in tumor cells in effusions and survival time has never been described before. Determination of telomerase activity on the cellular level provides a way to identify a subgroup of patients with a high probability of short survival.},
  author       = {Zendehrokh, Nooreldin and Franzen, Lina and Dejmek, Annika},
  issn         = {0001-5547},
  keyword      = {telomere repeat amplification,telomerase,carcinoma,effusions,protocol,survival},
  language     = {eng},
  number       = {3},
  pages        = {412--416},
  publisher    = {Science Printers and Publishers},
  series       = {Acta Cytologica},
  title        = {Weak telomerase activity in malignant cells in metastatic serous effusions - Correlation to short survival time},
  volume       = {51},
  year         = {2007},
}