Nephrotoxicity Surveillance for Childhood and Young Adult Survivors of Cancer : Recommendations From the International Late Effects of Childhood Cancer Guideline Harmonization Group
(2025) In Journal of Clinical Oncology 43(21). p.2433-2448- Abstract
PURPOSE Childhood, adolescent, and young adult (CAYA) survivors of cancer are at risk of nephrotoxicity. Surveillance guidelines are important for timely diagnosis and treatment of these survivors, which could slow the progression to higher stages of kidney dysfunction. METHODS The International Late Effects of Childhood Cancer Guideline Harmonization Group established a multidisciplinary panel of 34 experts from 11 countries. The panel performed systematic literature reviews for articles published between 1990 and June 2023, graded the evidence using Grading of Recommendations Assessment, Development, and Evaluation methodology, and formulated recommendations based on evidence, clinical judgment, and consideration of benefits and harms... (More)
PURPOSE Childhood, adolescent, and young adult (CAYA) survivors of cancer are at risk of nephrotoxicity. Surveillance guidelines are important for timely diagnosis and treatment of these survivors, which could slow the progression to higher stages of kidney dysfunction. METHODS The International Late Effects of Childhood Cancer Guideline Harmonization Group established a multidisciplinary panel of 34 experts from 11 countries. The panel performed systematic literature reviews for articles published between 1990 and June 2023, graded the evidence using Grading of Recommendations Assessment, Development, and Evaluation methodology, and formulated recommendations based on evidence, clinical judgment, and consideration of benefits and harms of surveillance. Recommendations were critically appraised by two independent external experts and patient representatives. RESULTS Glomerular dysfunction surveillance is recommended every 2-5 years for survivors treated with ifosfamide, cisplatin, abdominal radiotherapy, total body irradiation, or nephrectomy and is reasonable after carboplatin treatment. We recommend screening for glomerular dysfunction using an estimated glomerular filtration rate (eGFR) equation that includes serum creatinine, preferably combined with serum cystatin C if available. Tubular dysfunction surveillance is recommended once at entry into long-term follow-up and with follow-up as clinically indicated for survivors treated with ifosfamide and is reasonable after cisplatin treatment. CONCLUSION These recommendations inform routine, uniform long-term follow-up care for CAYA survivors of cancer at risk of nephrotoxicity.
(Less)
- author
- organization
- publishing date
- 2025-07
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Clinical Oncology
- volume
- 43
- issue
- 21
- pages
- 16 pages
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- scopus:105005760016
- pmid:40393013
- ISSN
- 0732-183X
- DOI
- 10.1200/JCO-24-02534
- language
- English
- LU publication?
- yes
- id
- 65b8e39f-58bc-4cd2-a1a4-fcd2933b13ca
- date added to LUP
- 2025-09-29 11:07:48
- date last changed
- 2025-10-17 10:55:27
@article{65b8e39f-58bc-4cd2-a1a4-fcd2933b13ca,
abstract = {{<p>PURPOSE Childhood, adolescent, and young adult (CAYA) survivors of cancer are at risk of nephrotoxicity. Surveillance guidelines are important for timely diagnosis and treatment of these survivors, which could slow the progression to higher stages of kidney dysfunction. METHODS The International Late Effects of Childhood Cancer Guideline Harmonization Group established a multidisciplinary panel of 34 experts from 11 countries. The panel performed systematic literature reviews for articles published between 1990 and June 2023, graded the evidence using Grading of Recommendations Assessment, Development, and Evaluation methodology, and formulated recommendations based on evidence, clinical judgment, and consideration of benefits and harms of surveillance. Recommendations were critically appraised by two independent external experts and patient representatives. RESULTS Glomerular dysfunction surveillance is recommended every 2-5 years for survivors treated with ifosfamide, cisplatin, abdominal radiotherapy, total body irradiation, or nephrectomy and is reasonable after carboplatin treatment. We recommend screening for glomerular dysfunction using an estimated glomerular filtration rate (eGFR) equation that includes serum creatinine, preferably combined with serum cystatin C if available. Tubular dysfunction surveillance is recommended once at entry into long-term follow-up and with follow-up as clinically indicated for survivors treated with ifosfamide and is reasonable after cisplatin treatment. CONCLUSION These recommendations inform routine, uniform long-term follow-up care for CAYA survivors of cancer at risk of nephrotoxicity.</p>}},
author = {{Kooijmans, Esmee C.M. and Mulder, Renée L. and Marks, Stephen D. and Pavasovic, Vesna and Motwani, Shveta S. and Walwyn, Thomas and Larkins, Nicholas G. and Kruseova, Jarmila and Constine, Louis S. and Hamish Wallace, W. and Green, Daniel M. and Bökenkamp, Arend and van der Pal, Helena J.H. and van den Heuvel-Eibrink, Marry M. and Hjorth, Lars and Andrés-Jensen, Liv and Bardi, Edit and van Dalen, Elvira C. and Demoor-Goldschmidt, Charlotte and Becktell, Kerri and Grönroos, Marika and Kieran, Kathleen and Mironova, Denitza and Terenziani, Monica and Veening, Margreet A. and Zieg, Jakub and Onder, Songul and Onder, Ali Mirza and Routh, Jonathan C. and Thompson, Joel and Hudson, Melissa M. and Kremer, Leontien C.M. and Skinner, Roderick and Ehrhardt, Matthew J.}},
issn = {{0732-183X}},
language = {{eng}},
number = {{21}},
pages = {{2433--2448}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Journal of Clinical Oncology}},
title = {{Nephrotoxicity Surveillance for Childhood and Young Adult Survivors of Cancer : Recommendations From the International Late Effects of Childhood Cancer Guideline Harmonization Group}},
url = {{http://dx.doi.org/10.1200/JCO-24-02534}},
doi = {{10.1200/JCO-24-02534}},
volume = {{43}},
year = {{2025}},
}