Nanotechnological Approaches to Therapeutic Delivery Using Elastin-Like Recombinamers
Rodríguez-Cabello, José Carlos ; Piña, María Jesús ; Ibáñez-Fonseca, Arturo LU
; Fernández-Colino, Alicia
and Arias, Francisco Javier
(2015)
In Bioconjugate Chemistry
26(7).
p.65-1252
- Abstract
This Review discusses the use of elastin-like polymers and their recombinant version, elastin-like recombinamers, in drug-delivery systems. These macromolecules exhibit a number of interesting properties that are rarely found together in any other family of materials, especially extremely high biocompatibility, high bioactivity and functionality, complex yet fully controlled composition, and stimuli responsiveness. Appropriate design of these molecules opens up a broad range of different possibilities for their use in new therapeutic platforms. The first of these described herein is the use of ELRs in single-molecule devices as therapeutic entities in their own right. Subsequently, we describe how the self-assembly properties of these... (More)
This Review discusses the use of elastin-like polymers and their recombinant version, elastin-like recombinamers, in drug-delivery systems. These macromolecules exhibit a number of interesting properties that are rarely found together in any other family of materials, especially extremely high biocompatibility, high bioactivity and functionality, complex yet fully controlled composition, and stimuli responsiveness. Appropriate design of these molecules opens up a broad range of different possibilities for their use in new therapeutic platforms. The first of these described herein is the use of ELRs in single-molecule devices as therapeutic entities in their own right. Subsequently, we describe how the self-assembly properties of these materials can be exploited to create nanocarriers and, eventually, microcarriers that are able to temporally and spatially control and direct the release of their drug load. Intracellular drug-delivery devices and nanocarriers for treating cancer are among the uses described in that section. Finally, the use of ELRs as base materials for implantable drug depots, in the form of hydrogels, is discussed.
(Less)
- author
- Rodríguez-Cabello, José Carlos
; Piña, María Jesús
; Ibáñez-Fonseca, Arturo
LU
; Fernández-Colino, Alicia
and Arias, Francisco Javier
- publishing date
- 2015-07-15
- type
- Contribution to journal
- publication status
- published
- keywords
- Animals, Drug Carriers/chemistry, Drug Delivery Systems/methods, Elastin/chemistry, Humans, Hydrogels/chemistry, Nanotechnology/methods, Recombinant Proteins/chemistry
- in
- Bioconjugate Chemistry
- volume
- 26
- issue
- 7
- pages
- 65 - 1252
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- pmid:26001189
- scopus:84937041753
- ISSN
- 1520-4812
- DOI
- 10.1021/acs.bioconjchem.5b00183
- language
- English
- LU publication?
- no
- id
- 65d34d70-ffc3-4da2-a334-207e276dfc4d
- date added to LUP
- 2025-09-14 19:39:52
- date last changed
- 2025-09-16 03:30:44
@article{65d34d70-ffc3-4da2-a334-207e276dfc4d,
abstract = {{<p>This Review discusses the use of elastin-like polymers and their recombinant version, elastin-like recombinamers, in drug-delivery systems. These macromolecules exhibit a number of interesting properties that are rarely found together in any other family of materials, especially extremely high biocompatibility, high bioactivity and functionality, complex yet fully controlled composition, and stimuli responsiveness. Appropriate design of these molecules opens up a broad range of different possibilities for their use in new therapeutic platforms. The first of these described herein is the use of ELRs in single-molecule devices as therapeutic entities in their own right. Subsequently, we describe how the self-assembly properties of these materials can be exploited to create nanocarriers and, eventually, microcarriers that are able to temporally and spatially control and direct the release of their drug load. Intracellular drug-delivery devices and nanocarriers for treating cancer are among the uses described in that section. Finally, the use of ELRs as base materials for implantable drug depots, in the form of hydrogels, is discussed.</p>}},
author = {{Rodríguez-Cabello, José Carlos and Piña, María Jesús and Ibáñez-Fonseca, Arturo and Fernández-Colino, Alicia and Arias, Francisco Javier}},
issn = {{1520-4812}},
keywords = {{Animals; Drug Carriers/chemistry; Drug Delivery Systems/methods; Elastin/chemistry; Humans; Hydrogels/chemistry; Nanotechnology/methods; Recombinant Proteins/chemistry}},
language = {{eng}},
month = {{07}},
number = {{7}},
pages = {{65--1252}},
publisher = {{The American Chemical Society (ACS)}},
series = {{Bioconjugate Chemistry}},
title = {{Nanotechnological Approaches to Therapeutic Delivery Using Elastin-Like Recombinamers}},
url = {{http://dx.doi.org/10.1021/acs.bioconjchem.5b00183}},
doi = {{10.1021/acs.bioconjchem.5b00183}},
volume = {{26}},
year = {{2015}},
}