Advanced

A novel partial volume correction method for accurate quantification of [18F] flortaucipir in the hippocampus

Wolters, Emma E.; Golla, Sandeep S.V.; Timmers, Tessa; Ossenkoppele, Rik LU ; van der Weijden, Chris W.J.; Scheltens, Philip; Schwarte, Lothar; Schuit, Robert C.; Windhorst, Albert D. and Barkhof, Frederik, et al. (2018) In EJNMMI Research 8.
Abstract

Background: Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC). Methods: PVC was performed on 20 [18F] flortaucipir dynamic PET scans (10 probable AD and 10 controls). Volumes of interest (VOIs) were defined for both hippocampus and CP. The correlation between hippocampal and CP distribution volume (VT), with and without PVC, was determined. Both anatomically defined and eroded VOIs were used. Results: For controls, the correlation between hippocampal and CP VT was significantly reduced... (More)

Background: Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC). Methods: PVC was performed on 20 [18F] flortaucipir dynamic PET scans (10 probable AD and 10 controls). Volumes of interest (VOIs) were defined for both hippocampus and CP. The correlation between hippocampal and CP distribution volume (VT), with and without PVC, was determined. Both anatomically defined and eroded VOIs were used. Results: For controls, the correlation between hippocampal and CP VT was significantly reduced after using PVC along with an eroded VOI (r2 = 0.59, slope = 0.80 versus r2 = 0.15, slope = 0.15; difference: p < 0.05). The same was true for AD patients (p < 0.05). Conclusion: PVC together with an optimized hippocampal VOI resulted in effective reduction of CP spill-in and improved accuracy of hippocampal VT.

(Less)
Please use this url to cite or link to this publication:
@article{65f27530-6252-4e5e-b754-e0f2c0f68a82,
  abstract     = {<p>Background: Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [<sup>18</sup>F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC). Methods: PVC was performed on 20 [<sup>18</sup>F] flortaucipir dynamic PET scans (10 probable AD and 10 controls). Volumes of interest (VOIs) were defined for both hippocampus and CP. The correlation between hippocampal and CP distribution volume (V<sub>T</sub>), with and without PVC, was determined. Both anatomically defined and eroded VOIs were used. Results: For controls, the correlation between hippocampal and CP V<sub>T</sub> was significantly reduced after using PVC along with an eroded VOI (r<sup>2</sup> = 0.59, slope = 0.80 versus r<sup>2</sup> = 0.15, slope = 0.15; difference: p &lt; 0.05). The same was true for AD patients (p &lt; 0.05). Conclusion: PVC together with an optimized hippocampal VOI resulted in effective reduction of CP spill-in and improved accuracy of hippocampal V<sub>T</sub>.</p>},
  articleno    = {79},
  author       = {Wolters, Emma E. and Golla, Sandeep S.V. and Timmers, Tessa and Ossenkoppele, Rik and van der Weijden, Chris W.J. and Scheltens, Philip and Schwarte, Lothar and Schuit, Robert C. and Windhorst, Albert D. and Barkhof, Frederik and Yaqub, Maqsood and Lammertsma, Adriaan A. and Boellaard, Ronald and van Berckel, Bart N.M.},
  issn         = {2191-219X},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {EJNMMI Research},
  title        = {A novel partial volume correction method for accurate quantification of [<sup>18</sup>F] flortaucipir in the hippocampus},
  url          = {http://dx.doi.org/10.1186/s13550-018-0432-2},
  volume       = {8},
  year         = {2018},
}