The prevalence of advanced interatrial block and its relationship to left atrial function in patients with transthyretin cardiac amyloidosis
(2021) In Journal of Clinical Medicine 10(13).- Abstract
Background: Advanced interatrial block (aIAB), which is associated with incident atrial fibrillation and stroke, occurs in the setting of blocked interatrial conduction. Atrial amyloid deposition could be a possible substrate for reduced interatrial conduction, but the prevalence of aIAB in patients with transthyretin cardiac amyloidosis (ATTR-CA) is unknown. We aimed to describe the prevalence of aIAB and its relationship to left atrial function in patients with ATTR-CA in comparison to patients with HF and left ventricular hypertrophy but no CA. Methods: The presence of aIAB was investigated among 75 patients (49 patients with ATTR-CA and 26 with HF but no CA). A comprehensive echocardiographic investigation was performed in all... (More)
Background: Advanced interatrial block (aIAB), which is associated with incident atrial fibrillation and stroke, occurs in the setting of blocked interatrial conduction. Atrial amyloid deposition could be a possible substrate for reduced interatrial conduction, but the prevalence of aIAB in patients with transthyretin cardiac amyloidosis (ATTR-CA) is unknown. We aimed to describe the prevalence of aIAB and its relationship to left atrial function in patients with ATTR-CA in comparison to patients with HF and left ventricular hypertrophy but no CA. Methods: The presence of aIAB was investigated among 75 patients (49 patients with ATTR-CA and 26 with HF but no CA). A comprehensive echocardiographic investigation was performed in all patients, including left atrial strain and strain rate measurements. Results: Among patients with ATTR-CA, 27% had aIAB and in patients with HF but no CA, this figure was 21%, (p = 0.78). The presence of aIAB was associated with a low strain rate during atrial contraction (<0.91 s−1) (OR: 5.2 (1.4–19.9)), even after adjusting for age and LAVi (OR: 4.5 (1.0–19.19)). Conclusion: Advanced interatrial block is common among patients with ATTR-CA, as well as in patients with heart failure and left ventricular hypertrophy but no CA. aIAB is associated with reduced left atrial contractile function.
(Less)
- author
- Lindow, Thomas and Lindqvist, Per
- publishing date
- 2021-07-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cardiac amyloidosis, Interatrial block, Left atrial strain, Transthyretin amyloid
- in
- Journal of Clinical Medicine
- volume
- 10
- issue
- 13
- article number
- 2764
- publisher
- MDPI AG
- external identifiers
-
- pmid:34201866
- scopus:85114079822
- ISSN
- 2077-0383
- DOI
- 10.3390/jcm10132764
- language
- English
- LU publication?
- no
- id
- 66034cc8-cc54-446e-a259-928d86315db4
- date added to LUP
- 2021-10-07 12:34:30
- date last changed
- 2024-06-29 18:37:48
@article{66034cc8-cc54-446e-a259-928d86315db4, abstract = {{<p>Background: Advanced interatrial block (aIAB), which is associated with incident atrial fibrillation and stroke, occurs in the setting of blocked interatrial conduction. Atrial amyloid deposition could be a possible substrate for reduced interatrial conduction, but the prevalence of aIAB in patients with transthyretin cardiac amyloidosis (ATTR-CA) is unknown. We aimed to describe the prevalence of aIAB and its relationship to left atrial function in patients with ATTR-CA in comparison to patients with HF and left ventricular hypertrophy but no CA. Methods: The presence of aIAB was investigated among 75 patients (49 patients with ATTR-CA and 26 with HF but no CA). A comprehensive echocardiographic investigation was performed in all patients, including left atrial strain and strain rate measurements. Results: Among patients with ATTR-CA, 27% had aIAB and in patients with HF but no CA, this figure was 21%, (p = 0.78). The presence of aIAB was associated with a low strain rate during atrial contraction (<0.91 s<sup>−1</sup>) (OR: 5.2 (1.4–19.9)), even after adjusting for age and LAVi (OR: 4.5 (1.0–19.19)). Conclusion: Advanced interatrial block is common among patients with ATTR-CA, as well as in patients with heart failure and left ventricular hypertrophy but no CA. aIAB is associated with reduced left atrial contractile function.</p>}}, author = {{Lindow, Thomas and Lindqvist, Per}}, issn = {{2077-0383}}, keywords = {{Cardiac amyloidosis; Interatrial block; Left atrial strain; Transthyretin amyloid}}, language = {{eng}}, month = {{07}}, number = {{13}}, publisher = {{MDPI AG}}, series = {{Journal of Clinical Medicine}}, title = {{The prevalence of advanced interatrial block and its relationship to left atrial function in patients with transthyretin cardiac amyloidosis}}, url = {{http://dx.doi.org/10.3390/jcm10132764}}, doi = {{10.3390/jcm10132764}}, volume = {{10}}, year = {{2021}}, }