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The prevalence of advanced interatrial block and its relationship to left atrial function in patients with transthyretin cardiac amyloidosis

Lindow, Thomas and Lindqvist, Per (2021) In Journal of Clinical Medicine 10(13).
Abstract

Background: Advanced interatrial block (aIAB), which is associated with incident atrial fibrillation and stroke, occurs in the setting of blocked interatrial conduction. Atrial amyloid deposition could be a possible substrate for reduced interatrial conduction, but the prevalence of aIAB in patients with transthyretin cardiac amyloidosis (ATTR-CA) is unknown. We aimed to describe the prevalence of aIAB and its relationship to left atrial function in patients with ATTR-CA in comparison to patients with HF and left ventricular hypertrophy but no CA. Methods: The presence of aIAB was investigated among 75 patients (49 patients with ATTR-CA and 26 with HF but no CA). A comprehensive echocardiographic investigation was performed in all... (More)

Background: Advanced interatrial block (aIAB), which is associated with incident atrial fibrillation and stroke, occurs in the setting of blocked interatrial conduction. Atrial amyloid deposition could be a possible substrate for reduced interatrial conduction, but the prevalence of aIAB in patients with transthyretin cardiac amyloidosis (ATTR-CA) is unknown. We aimed to describe the prevalence of aIAB and its relationship to left atrial function in patients with ATTR-CA in comparison to patients with HF and left ventricular hypertrophy but no CA. Methods: The presence of aIAB was investigated among 75 patients (49 patients with ATTR-CA and 26 with HF but no CA). A comprehensive echocardiographic investigation was performed in all patients, including left atrial strain and strain rate measurements. Results: Among patients with ATTR-CA, 27% had aIAB and in patients with HF but no CA, this figure was 21%, (p = 0.78). The presence of aIAB was associated with a low strain rate during atrial contraction (<0.91 s−1) (OR: 5.2 (1.4–19.9)), even after adjusting for age and LAVi (OR: 4.5 (1.0–19.19)). Conclusion: Advanced interatrial block is common among patients with ATTR-CA, as well as in patients with heart failure and left ventricular hypertrophy but no CA. aIAB is associated with reduced left atrial contractile function.

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author
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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiac amyloidosis, Interatrial block, Left atrial strain, Transthyretin amyloid
in
Journal of Clinical Medicine
volume
10
issue
13
article number
2764
publisher
MDPI AG
external identifiers
  • pmid:34201866
  • scopus:85114079822
ISSN
2077-0383
DOI
10.3390/jcm10132764
language
English
LU publication?
no
id
66034cc8-cc54-446e-a259-928d86315db4
date added to LUP
2021-10-07 12:34:30
date last changed
2024-07-13 19:55:51
@article{66034cc8-cc54-446e-a259-928d86315db4,
  abstract     = {{<p>Background: Advanced interatrial block (aIAB), which is associated with incident atrial fibrillation and stroke, occurs in the setting of blocked interatrial conduction. Atrial amyloid deposition could be a possible substrate for reduced interatrial conduction, but the prevalence of aIAB in patients with transthyretin cardiac amyloidosis (ATTR-CA) is unknown. We aimed to describe the prevalence of aIAB and its relationship to left atrial function in patients with ATTR-CA in comparison to patients with HF and left ventricular hypertrophy but no CA. Methods: The presence of aIAB was investigated among 75 patients (49 patients with ATTR-CA and 26 with HF but no CA). A comprehensive echocardiographic investigation was performed in all patients, including left atrial strain and strain rate measurements. Results: Among patients with ATTR-CA, 27% had aIAB and in patients with HF but no CA, this figure was 21%, (p = 0.78). The presence of aIAB was associated with a low strain rate during atrial contraction (&lt;0.91 s<sup>−1</sup>) (OR: 5.2 (1.4–19.9)), even after adjusting for age and LAVi (OR: 4.5 (1.0–19.19)). Conclusion: Advanced interatrial block is common among patients with ATTR-CA, as well as in patients with heart failure and left ventricular hypertrophy but no CA. aIAB is associated with reduced left atrial contractile function.</p>}},
  author       = {{Lindow, Thomas and Lindqvist, Per}},
  issn         = {{2077-0383}},
  keywords     = {{Cardiac amyloidosis; Interatrial block; Left atrial strain; Transthyretin amyloid}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{13}},
  publisher    = {{MDPI AG}},
  series       = {{Journal of Clinical Medicine}},
  title        = {{The prevalence of advanced interatrial block and its relationship to left atrial function in patients with transthyretin cardiac amyloidosis}},
  url          = {{http://dx.doi.org/10.3390/jcm10132764}},
  doi          = {{10.3390/jcm10132764}},
  volume       = {{10}},
  year         = {{2021}},
}