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Reduced aortic wall stress in diabetes mellitus

Astrand, H.; Rydén Ahlgren, Åsa LU ; Sundkvist, Göran LU ; Sandgren, T. and Lanne, T. (2007) In European Journal of Vascular and Endovascular Surgery 33(5). p.592-598
Abstract
Objective. Most risk factors are similar for abdominal aortic aneurysm (AAA) and atherosclerosis, e.g. smoking, male gender, age, high blood pressure, hyperlipidemia. Diabetes mellitus however, is a risk factor for atherosclerosis, but diabetic patients seldom develop AAA. The reason for this discrepancy is unknown. Increased aortic wall stress seems to be all etiologic factor in the formation, growth and rupture of AAA in man. The aim of our study was to study the wall stress in the abdominal aorta in diabetic patients compared with healthy controls. Methods. 39 patients with diabetes mellitus and 46 age - and sex matched healthy subjects were examined with B-mode ultrasound to determine the lumen diameter (LD) and intima-media thickness... (More)
Objective. Most risk factors are similar for abdominal aortic aneurysm (AAA) and atherosclerosis, e.g. smoking, male gender, age, high blood pressure, hyperlipidemia. Diabetes mellitus however, is a risk factor for atherosclerosis, but diabetic patients seldom develop AAA. The reason for this discrepancy is unknown. Increased aortic wall stress seems to be all etiologic factor in the formation, growth and rupture of AAA in man. The aim of our study was to study the wall stress in the abdominal aorta in diabetic patients compared with healthy controls. Methods. 39 patients with diabetes mellitus and 46 age - and sex matched healthy subjects were examined with B-mode ultrasound to determine the lumen diameter (LD) and intima-media thickness (IMT) in the abdominal aorta (AA) and the common carotid artery (CCA). Diastolic blood pressure (DBP) was measured non-invasively in the brachial artery. LaPlace law was used to calculate circumferential wall stress. Results. Age, DBP, and LD in the abdominal aorta were not significantly different in the diabetic patients compared to controls. IMT in the AA was larger in the diabetic patients, 0.89 +/- 0.17 vs 0.73 +/- 0.11 mm (p <.001). Accordingly aortic wall stress was reduced in the diabetics, 7.8 +/- 1.7 x 10(5) vs 9.7 +/- 1.9 x 10(5) dynes/cm(2) (P <.001). Conclusions. Wall stress in the abdominal aorta is reduced in diabetes mellitus. This is mainly due to a thicker aortic wall compared to healthy controls. The reduced aortic wall stress coincides with the fact that epidemiological studies have shown a decreased risk of aneurysm development in diabetic patients. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
wall tension, stress, wall, intima-media thickness, abdominal aorta, diabetes mellitus, aneurysm
in
European Journal of Vascular and Endovascular Surgery
volume
33
issue
5
pages
592 - 598
publisher
Elsevier
external identifiers
  • wos:000246295200016
  • scopus:34047261850
ISSN
1532-2165
DOI
10.1016/j.ejvs.2006.11.011
language
English
LU publication?
yes
id
f461315c-a6af-45cb-8461-bdde8cc03626 (old id 660517)
date added to LUP
2007-12-06 16:53:44
date last changed
2017-08-27 05:17:13
@article{f461315c-a6af-45cb-8461-bdde8cc03626,
  abstract     = {Objective. Most risk factors are similar for abdominal aortic aneurysm (AAA) and atherosclerosis, e.g. smoking, male gender, age, high blood pressure, hyperlipidemia. Diabetes mellitus however, is a risk factor for atherosclerosis, but diabetic patients seldom develop AAA. The reason for this discrepancy is unknown. Increased aortic wall stress seems to be all etiologic factor in the formation, growth and rupture of AAA in man. The aim of our study was to study the wall stress in the abdominal aorta in diabetic patients compared with healthy controls. Methods. 39 patients with diabetes mellitus and 46 age - and sex matched healthy subjects were examined with B-mode ultrasound to determine the lumen diameter (LD) and intima-media thickness (IMT) in the abdominal aorta (AA) and the common carotid artery (CCA). Diastolic blood pressure (DBP) was measured non-invasively in the brachial artery. LaPlace law was used to calculate circumferential wall stress. Results. Age, DBP, and LD in the abdominal aorta were not significantly different in the diabetic patients compared to controls. IMT in the AA was larger in the diabetic patients, 0.89 +/- 0.17 vs 0.73 +/- 0.11 mm (p &lt;.001). Accordingly aortic wall stress was reduced in the diabetics, 7.8 +/- 1.7 x 10(5) vs 9.7 +/- 1.9 x 10(5) dynes/cm(2) (P &lt;.001). Conclusions. Wall stress in the abdominal aorta is reduced in diabetes mellitus. This is mainly due to a thicker aortic wall compared to healthy controls. The reduced aortic wall stress coincides with the fact that epidemiological studies have shown a decreased risk of aneurysm development in diabetic patients.},
  author       = {Astrand, H. and Rydén Ahlgren, Åsa and Sundkvist, Göran and Sandgren, T. and Lanne, T.},
  issn         = {1532-2165},
  keyword      = {wall tension,stress,wall,intima-media thickness,abdominal aorta,diabetes mellitus,aneurysm},
  language     = {eng},
  number       = {5},
  pages        = {592--598},
  publisher    = {Elsevier},
  series       = {European Journal of Vascular and Endovascular Surgery},
  title        = {Reduced aortic wall stress in diabetes mellitus},
  url          = {http://dx.doi.org/10.1016/j.ejvs.2006.11.011},
  volume       = {33},
  year         = {2007},
}