Cerebral microvascular injuries in severe COVID-19 infection: progression of white matter hyperintensities post-infection
Petersson, Ida ; Hansen, Bjorn M LU
; Svenningsson, Anders
and Lundstrom, Annika
(2022)
In BMJ Case Reports
15(9).
p.1-5
- Abstract
- A range of neuroradiological findings has been reported in patients with COVID-19, some mimicking cerebral small vessel disease (CSVD). We present a case of a man in his 50s with severe COVID-19, who was Glasgow Coma Scale 3 and tetraparetic after sedation was ceased in the intensive care unit. Return of consciousness and motor activity was slow. An MRI 1 month after debut of symptoms demonstrated white matter hyperintensities on T2-weighted Fluid Attenuated Inversion Recovery (T2-FLAIR) and many small areas with impaired diffusion in primarily supratentorial and infratentorial white matter on Diffusion-Weighted Imaging (DWI). In the following months, the patient made a remarkable clinical recovery. Despite clinical improvement, an MRI... (More)
- A range of neuroradiological findings has been reported in patients with COVID-19, some mimicking cerebral small vessel disease (CSVD). We present a case of a man in his 50s with severe COVID-19, who was Glasgow Coma Scale 3 and tetraparetic after sedation was ceased in the intensive care unit. Return of consciousness and motor activity was slow. An MRI 1 month after debut of symptoms demonstrated white matter hyperintensities on T2-weighted Fluid Attenuated Inversion Recovery (T2-FLAIR) and many small areas with impaired diffusion in primarily supratentorial and infratentorial white matter on Diffusion-Weighted Imaging (DWI). In the following months, the patient made a remarkable clinical recovery. Despite clinical improvement, an MRI after 7 months showed that white matter hyperintensities had progressed and become confluent. Both MRIs demonstrated findings resembling CSVD, which could relate to a COVID-19-specific process affecting cerebral microvasculature. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/66074417-6292-42a3-bf32-cb670e4d26e6
- author
- Petersson, Ida
; Hansen, Bjorn M
LU
; Svenningsson, Anders
and Lundstrom, Annika
- publishing date
- 2022-09-01
- type
- Contribution to journal
- publication status
- published
- in
- BMJ Case Reports
- volume
- 15
- issue
- 9
- article number
- e249156
- pages
- 1 - 5
- publisher
- BMJ Publishing Group
- external identifiers
-
- scopus:85137792004
- ISSN
- 1757-790X
- DOI
- 10.1136/bcr-2022-249156
- language
- English
- LU publication?
- no
- id
- 66074417-6292-42a3-bf32-cb670e4d26e6
- date added to LUP
- 2025-05-31 15:18:37
- date last changed
- 2025-10-14 10:27:14
@article{66074417-6292-42a3-bf32-cb670e4d26e6,
abstract = {{A range of neuroradiological findings has been reported in patients with COVID-19, some mimicking cerebral small vessel disease (CSVD). We present a case of a man in his 50s with severe COVID-19, who was Glasgow Coma Scale 3 and tetraparetic after sedation was ceased in the intensive care unit. Return of consciousness and motor activity was slow. An MRI 1 month after debut of symptoms demonstrated white matter hyperintensities on T2-weighted Fluid Attenuated Inversion Recovery (T2-FLAIR) and many small areas with impaired diffusion in primarily supratentorial and infratentorial white matter on Diffusion-Weighted Imaging (DWI). In the following months, the patient made a remarkable clinical recovery. Despite clinical improvement, an MRI after 7 months showed that white matter hyperintensities had progressed and become confluent. Both MRIs demonstrated findings resembling CSVD, which could relate to a COVID-19-specific process affecting cerebral microvasculature.}},
author = {{Petersson, Ida and Hansen, Bjorn M and Svenningsson, Anders and Lundstrom, Annika}},
issn = {{1757-790X}},
language = {{eng}},
month = {{09}},
number = {{9}},
pages = {{1--5}},
publisher = {{BMJ Publishing Group}},
series = {{BMJ Case Reports}},
title = {{Cerebral microvascular injuries in severe COVID-19 infection: progression of white matter hyperintensities post-infection}},
url = {{http://dx.doi.org/10.1136/bcr-2022-249156}},
doi = {{10.1136/bcr-2022-249156}},
volume = {{15}},
year = {{2022}},
}