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The Polycomb-group gene, extra sex combs, encodes a nuclear member of the WD-40 repeat family

Gutjahr, T. ; Frei, E. ; Spicer, C. ; Baumgartner, S. LU orcid ; White, R. A.H. and Noll, M. (1995) In EMBO Journal 14(17). p.4296-4306
Abstract

We have delimited the extra sex combs (esc) gene to <4 kb that include a single transcript and are able to rescue both the maternal and zygotic esc phenotypes. Several mutations have been identified within the esc transcript. In agreement with earlier genetic studies, esc is expressed maternally and its product is most abundant during the early embryonic stages. It encodes a protein of the WD-40 repeat family, which localizes predominantly to the nucleus. During germ band extension, it is expressed in a stereotypic pattern of neuroblasts. We propose a model in which Esc is recruited by gap proteins both to act as a corepressor that competes with the TAF(II)80 coactivator to block transcription and also to mediate the transition to... (More)

We have delimited the extra sex combs (esc) gene to <4 kb that include a single transcript and are able to rescue both the maternal and zygotic esc phenotypes. Several mutations have been identified within the esc transcript. In agreement with earlier genetic studies, esc is expressed maternally and its product is most abundant during the early embryonic stages. It encodes a protein of the WD-40 repeat family, which localizes predominantly to the nucleus. During germ band extension, it is expressed in a stereotypic pattern of neuroblasts. We propose a model in which Esc is recruited by gap proteins both to act as a corepressor that competes with the TAF(II)80 coactivator to block transcription and also to mediate the transition to permanent repression by Polycomb-group proteins.

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author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Extra sex combs, Gene silencing, Homeosis, Polycomb group, WD-40 repeat
in
EMBO Journal
volume
14
issue
17
pages
4296 - 4306
publisher
Oxford University Press
external identifiers
  • scopus:0029122551
  • pmid:7556071
ISSN
0261-4189
DOI
10.1002/j.1460-2075.1995.tb00104.x
language
English
LU publication?
no
id
6608f17c-904d-4925-8bdc-9cef2cd7efda
date added to LUP
2019-05-21 14:07:13
date last changed
2024-01-01 05:54:21
@article{6608f17c-904d-4925-8bdc-9cef2cd7efda,
  abstract     = {{<p>We have delimited the extra sex combs (esc) gene to &lt;4 kb that include a single transcript and are able to rescue both the maternal and zygotic esc phenotypes. Several mutations have been identified within the esc transcript. In agreement with earlier genetic studies, esc is expressed maternally and its product is most abundant during the early embryonic stages. It encodes a protein of the WD-40 repeat family, which localizes predominantly to the nucleus. During germ band extension, it is expressed in a stereotypic pattern of neuroblasts. We propose a model in which Esc is recruited by gap proteins both to act as a corepressor that competes with the TAF(II)80 coactivator to block transcription and also to mediate the transition to permanent repression by Polycomb-group proteins.</p>}},
  author       = {{Gutjahr, T. and Frei, E. and Spicer, C. and Baumgartner, S. and White, R. A.H. and Noll, M.}},
  issn         = {{0261-4189}},
  keywords     = {{Extra sex combs; Gene silencing; Homeosis; Polycomb group; WD-40 repeat}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{17}},
  pages        = {{4296--4306}},
  publisher    = {{Oxford University Press}},
  series       = {{EMBO Journal}},
  title        = {{The Polycomb-group gene, extra sex combs, encodes a nuclear member of the WD-40 repeat family}},
  url          = {{http://dx.doi.org/10.1002/j.1460-2075.1995.tb00104.x}},
  doi          = {{10.1002/j.1460-2075.1995.tb00104.x}},
  volume       = {{14}},
  year         = {{1995}},
}