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Association studies of BMI and type 2 diabetes in the neuropeptide y pathway - A possible role for NPY2R as a candidate gene for type 2 diabetes in men

Campbell, Catarina D.; Lyon, Helen N.; Nemesh, James; Drake, Jared A.; Tuomi, Tiinamaija; Gaudet, Daniel; Zhu, Xiaofeng; Cooper, Richard S.; Ardlie, Kristin G. and Groop, Leif LU , et al. (2007) In Diabetes 56(5). p.1460-1467
Abstract
The neuropeptide Y (NPY) family of peptides and receptors regulate food intake. Inherited variation in this pathway could influence susceptibility to obesity and its complications, including type 2 diabetes. We genotyped a set of 71 single nucleotide polymorphisms (SNPs) that capture the most common variation in NPY, PPY, PYY, NPY1R, NPY2R, and NPY5R in 2,800 individuals of recent European ancestry drawn from the near extremes of BMI distribution. Five SNPs located upstream of NPY2R were nominally associated with BMI in men (P values = 0.001-0.009, odds ratios [ORs] 1.27-1.34). No association with BMI was observed in women, and no consistent associations were observed for other genes in this pathway. We attempted to replicate the... (More)
The neuropeptide Y (NPY) family of peptides and receptors regulate food intake. Inherited variation in this pathway could influence susceptibility to obesity and its complications, including type 2 diabetes. We genotyped a set of 71 single nucleotide polymorphisms (SNPs) that capture the most common variation in NPY, PPY, PYY, NPY1R, NPY2R, and NPY5R in 2,800 individuals of recent European ancestry drawn from the near extremes of BMI distribution. Five SNPs located upstream of NPY2R were nominally associated with BMI in men (P values = 0.001-0.009, odds ratios [ORs] 1.27-1.34). No association with BMI was observed in women, and no consistent associations were observed for other genes in this pathway. We attempted to replicate the association with BMI in 2,500 men and tested these SNPs for association with type 2 diabetes in 8,000 samples. We observed association with BMI in men in only one replica- tion sample and saw no association in the combined replication samples (P = 0.154, OR = 1.09). Finally, a 9% haplotype was associated with type 2 diabetes in men (P = 1.73 x 10(-4), OR = 1.36) and not in women. Variation in this pathway likely does not have a major influence on BMI, although small effects cannot be ruled out; NPY2R should be considered a candidate gene for type 2 diabetes in men. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes
volume
56
issue
5
pages
1460 - 1467
publisher
American Diabetes Association Inc.
external identifiers
  • wos:000246291500033
  • scopus:34248154742
ISSN
1939-327X
DOI
10.2337/db06-1051
language
English
LU publication?
yes
id
86cf23bf-10ec-4b3e-bd7b-d83b725cfddc (old id 662733)
date added to LUP
2007-12-05 15:05:44
date last changed
2017-07-02 04:27:37
@article{86cf23bf-10ec-4b3e-bd7b-d83b725cfddc,
  abstract     = {The neuropeptide Y (NPY) family of peptides and receptors regulate food intake. Inherited variation in this pathway could influence susceptibility to obesity and its complications, including type 2 diabetes. We genotyped a set of 71 single nucleotide polymorphisms (SNPs) that capture the most common variation in NPY, PPY, PYY, NPY1R, NPY2R, and NPY5R in 2,800 individuals of recent European ancestry drawn from the near extremes of BMI distribution. Five SNPs located upstream of NPY2R were nominally associated with BMI in men (P values = 0.001-0.009, odds ratios [ORs] 1.27-1.34). No association with BMI was observed in women, and no consistent associations were observed for other genes in this pathway. We attempted to replicate the association with BMI in 2,500 men and tested these SNPs for association with type 2 diabetes in 8,000 samples. We observed association with BMI in men in only one replica- tion sample and saw no association in the combined replication samples (P = 0.154, OR = 1.09). Finally, a 9% haplotype was associated with type 2 diabetes in men (P = 1.73 x 10(-4), OR = 1.36) and not in women. Variation in this pathway likely does not have a major influence on BMI, although small effects cannot be ruled out; NPY2R should be considered a candidate gene for type 2 diabetes in men.},
  author       = {Campbell, Catarina D. and Lyon, Helen N. and Nemesh, James and Drake, Jared A. and Tuomi, Tiinamaija and Gaudet, Daniel and Zhu, Xiaofeng and Cooper, Richard S. and Ardlie, Kristin G. and Groop, Leif and Hirschhorn, Joel N.},
  issn         = {1939-327X},
  language     = {eng},
  number       = {5},
  pages        = {1460--1467},
  publisher    = {American Diabetes Association Inc.},
  series       = {Diabetes},
  title        = {Association studies of BMI and type 2 diabetes in the neuropeptide y pathway - A possible role for NPY2R as a candidate gene for type 2 diabetes in men},
  url          = {http://dx.doi.org/10.2337/db06-1051},
  volume       = {56},
  year         = {2007},
}