Redox Chemistry of Hemoglobin-Associated Disorders
(2017) In Antioxidants and Redox Signaling 26(14). p.745-747- Abstract
This Forum addresses oxidative reactions of hemoglobin (Hb) and explores the underlying mechanisms of some of these reactions that contribute to the pathophysiology associated with hemolytic anemia and Hb-based oxygen therapeutics. A special focus of this Forum is on the understanding of naturally occurring mutations in human Hb and how these mutations were influenced overtime by variety of oxidative stresses. What emerges from these contributions is that some hemoglobinopathies involve mutant Hb that resists oxidative challenges, whereas the majority often result in circulatory disorder. The contributors provide in-depth and comprehensive overviews on selected key mechanisms underlying Hb oxidative reactions in health and in disease... (More)
This Forum addresses oxidative reactions of hemoglobin (Hb) and explores the underlying mechanisms of some of these reactions that contribute to the pathophysiology associated with hemolytic anemia and Hb-based oxygen therapeutics. A special focus of this Forum is on the understanding of naturally occurring mutations in human Hb and how these mutations were influenced overtime by variety of oxidative stresses. What emerges from these contributions is that some hemoglobinopathies involve mutant Hb that resists oxidative challenges, whereas the majority often result in circulatory disorder. The contributors provide in-depth and comprehensive overviews on selected key mechanisms underlying Hb oxidative reactions in health and in disease states and how this knowledge may help in the design of countermeasures against these oxidative and toxicological pathways. Antioxid. Redox Signal. 26, 745-747.
(Less)
- author
- Bulow, Leif LU and Alayash, Abdu I.
- organization
- publishing date
- 2017-05-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- blood, hemoglobin disorders, mutations, oxidation reactions
- in
- Antioxidants and Redox Signaling
- volume
- 26
- issue
- 14
- pages
- 3 pages
- publisher
- Mary Ann Liebert, Inc.
- external identifiers
-
- scopus:85018996116
- pmid:28398821
- wos:000400288100001
- ISSN
- 1523-0864
- DOI
- 10.1089/ars.2016.6948
- language
- English
- LU publication?
- yes
- id
- 662878c1-b3a4-4fb6-8966-e795586af845
- date added to LUP
- 2017-05-31 08:18:29
- date last changed
- 2025-01-06 14:06:08
@article{662878c1-b3a4-4fb6-8966-e795586af845,
abstract = {{<p>This Forum addresses oxidative reactions of hemoglobin (Hb) and explores the underlying mechanisms of some of these reactions that contribute to the pathophysiology associated with hemolytic anemia and Hb-based oxygen therapeutics. A special focus of this Forum is on the understanding of naturally occurring mutations in human Hb and how these mutations were influenced overtime by variety of oxidative stresses. What emerges from these contributions is that some hemoglobinopathies involve mutant Hb that resists oxidative challenges, whereas the majority often result in circulatory disorder. The contributors provide in-depth and comprehensive overviews on selected key mechanisms underlying Hb oxidative reactions in health and in disease states and how this knowledge may help in the design of countermeasures against these oxidative and toxicological pathways. Antioxid. Redox Signal. 26, 745-747.</p>}},
author = {{Bulow, Leif and Alayash, Abdu I.}},
issn = {{1523-0864}},
keywords = {{blood; hemoglobin disorders; mutations; oxidation reactions}},
language = {{eng}},
month = {{05}},
number = {{14}},
pages = {{745--747}},
publisher = {{Mary Ann Liebert, Inc.}},
series = {{Antioxidants and Redox Signaling}},
title = {{Redox Chemistry of Hemoglobin-Associated Disorders}},
url = {{http://dx.doi.org/10.1089/ars.2016.6948}},
doi = {{10.1089/ars.2016.6948}},
volume = {{26}},
year = {{2017}},
}