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Redox Chemistry of Hemoglobin-Associated Disorders

Bulow, Leif LU and Alayash, Abdu I. (2017) In Antioxidants and Redox Signaling 26(14). p.745-747
Abstract

This Forum addresses oxidative reactions of hemoglobin (Hb) and explores the underlying mechanisms of some of these reactions that contribute to the pathophysiology associated with hemolytic anemia and Hb-based oxygen therapeutics. A special focus of this Forum is on the understanding of naturally occurring mutations in human Hb and how these mutations were influenced overtime by variety of oxidative stresses. What emerges from these contributions is that some hemoglobinopathies involve mutant Hb that resists oxidative challenges, whereas the majority often result in circulatory disorder. The contributors provide in-depth and comprehensive overviews on selected key mechanisms underlying Hb oxidative reactions in health and in disease... (More)

This Forum addresses oxidative reactions of hemoglobin (Hb) and explores the underlying mechanisms of some of these reactions that contribute to the pathophysiology associated with hemolytic anemia and Hb-based oxygen therapeutics. A special focus of this Forum is on the understanding of naturally occurring mutations in human Hb and how these mutations were influenced overtime by variety of oxidative stresses. What emerges from these contributions is that some hemoglobinopathies involve mutant Hb that resists oxidative challenges, whereas the majority often result in circulatory disorder. The contributors provide in-depth and comprehensive overviews on selected key mechanisms underlying Hb oxidative reactions in health and in disease states and how this knowledge may help in the design of countermeasures against these oxidative and toxicological pathways. Antioxid. Redox Signal. 26, 745-747.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
blood, hemoglobin disorders, mutations, oxidation reactions
in
Antioxidants and Redox Signaling
volume
26
issue
14
pages
3 pages
publisher
Mary Ann Liebert, Inc.
external identifiers
  • scopus:85018996116
  • wos:000400288100001
ISSN
1523-0864
DOI
10.1089/ars.2016.6948
language
English
LU publication?
yes
id
662878c1-b3a4-4fb6-8966-e795586af845
date added to LUP
2017-05-31 08:18:29
date last changed
2017-09-18 11:38:10
@article{662878c1-b3a4-4fb6-8966-e795586af845,
  abstract     = {<p>This Forum addresses oxidative reactions of hemoglobin (Hb) and explores the underlying mechanisms of some of these reactions that contribute to the pathophysiology associated with hemolytic anemia and Hb-based oxygen therapeutics. A special focus of this Forum is on the understanding of naturally occurring mutations in human Hb and how these mutations were influenced overtime by variety of oxidative stresses. What emerges from these contributions is that some hemoglobinopathies involve mutant Hb that resists oxidative challenges, whereas the majority often result in circulatory disorder. The contributors provide in-depth and comprehensive overviews on selected key mechanisms underlying Hb oxidative reactions in health and in disease states and how this knowledge may help in the design of countermeasures against these oxidative and toxicological pathways. Antioxid. Redox Signal. 26, 745-747.</p>},
  author       = {Bulow, Leif and Alayash, Abdu I.},
  issn         = {1523-0864},
  keyword      = {blood,hemoglobin disorders,mutations,oxidation reactions},
  language     = {eng},
  month        = {05},
  number       = {14},
  pages        = {745--747},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Antioxidants and Redox Signaling},
  title        = {Redox Chemistry of Hemoglobin-Associated Disorders},
  url          = {http://dx.doi.org/10.1089/ars.2016.6948},
  volume       = {26},
  year         = {2017},
}