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Mid-term effects of lung volume reduction surgery on pulmonary function in patients with chronic obstructive pulmonary disease

Liu, Jin-ming; Yang, Wen-lan; Jiang, Ge-ning; Ding, Jia-an; Zheng, Wei; Liu, Wen-zeng; Wang, Ying-min; Gao, Bei-lan; Jiang, Ping and Wu, Wen, et al. (2007) In Chinese Medical Journal 120(8). p.658-662
Abstract
Background Now lung volume reduction surgery (LVRS) has become one of the most effective methods for the management of some cases of severe chronic obstructive pulmonary disease (COPD). We evaluated the mid-term effects of LVRS on pulmonary function in patients with severe COPD. Methods Ten male patients with severe COPD aged 38-70 years underwent LVRS and their pulmonary function was assessed before, 3 months and 3 years after surgery. The spirometric and gas exchange parameters included residual volume, total lung capacity, inspiratory capacity, forced vital capacity, forced expiratory volume in one second, diffusion capacity for CO, and arterial blood gas. A 6-minute walk distance (6MWD) test was performed. Results As to preoperative... (More)
Background Now lung volume reduction surgery (LVRS) has become one of the most effective methods for the management of some cases of severe chronic obstructive pulmonary disease (COPD). We evaluated the mid-term effects of LVRS on pulmonary function in patients with severe COPD. Methods Ten male patients with severe COPD aged 38-70 years underwent LVRS and their pulmonary function was assessed before, 3 months and 3 years after surgery. The spirometric and gas exchange parameters included residual volume, total lung capacity, inspiratory capacity, forced vital capacity, forced expiratory volume in one second, diffusion capacity for CO, and arterial blood gas. A 6-minute walk distance (6MWD) test was performed. Results As to preoperative assessment, most spirometric parameters and 6MWD were significantly improved after 3 months and slightly 3 years after LVRS. Gas exchange parameters were significantly improved 3 months after surgery, but returned to the preoperative levels after 3 years. Conclusions LVRS may significantly improve pulmonary function in patients with severe COPD indicating for LVRS. Mid-term pulmonary function 3 years after surgery can be decreased to the level at 3 months after surgery. Three years after LVRS, lung volume and pulmonary ventilation function can be significantly improved, but the improvement in gas exchange function was not significant. (Less)
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Contribution to journal
publication status
published
subject
keywords
pulmonary function, treatment outcome, lung volume reduction surgery, chronic obstructive pulmonary disease
in
Chinese Medical Journal
volume
120
issue
8
pages
658 - 662
publisher
Chinese Medical Association
external identifiers
  • wos:000246165000009
  • scopus:34248638239
ISSN
0366-6999
language
English
LU publication?
yes
id
3f733727-af03-4a7e-9155-28b23f9d5695 (old id 663169)
alternative location
http://www.cmj.org/Periodical/AbstractList.asp?titleid=LW2007419414494804239
date added to LUP
2007-12-17 08:58:28
date last changed
2017-01-01 07:09:25
@article{3f733727-af03-4a7e-9155-28b23f9d5695,
  abstract     = {Background Now lung volume reduction surgery (LVRS) has become one of the most effective methods for the management of some cases of severe chronic obstructive pulmonary disease (COPD). We evaluated the mid-term effects of LVRS on pulmonary function in patients with severe COPD. Methods Ten male patients with severe COPD aged 38-70 years underwent LVRS and their pulmonary function was assessed before, 3 months and 3 years after surgery. The spirometric and gas exchange parameters included residual volume, total lung capacity, inspiratory capacity, forced vital capacity, forced expiratory volume in one second, diffusion capacity for CO, and arterial blood gas. A 6-minute walk distance (6MWD) test was performed. Results As to preoperative assessment, most spirometric parameters and 6MWD were significantly improved after 3 months and slightly 3 years after LVRS. Gas exchange parameters were significantly improved 3 months after surgery, but returned to the preoperative levels after 3 years. Conclusions LVRS may significantly improve pulmonary function in patients with severe COPD indicating for LVRS. Mid-term pulmonary function 3 years after surgery can be decreased to the level at 3 months after surgery. Three years after LVRS, lung volume and pulmonary ventilation function can be significantly improved, but the improvement in gas exchange function was not significant.},
  author       = {Liu, Jin-ming and Yang, Wen-lan and Jiang, Ge-ning and Ding, Jia-an and Zheng, Wei and Liu, Wen-zeng and Wang, Ying-min and Gao, Bei-lan and Jiang, Ping and Wu, Wen and Li, Xia and Jonson, Björn},
  issn         = {0366-6999},
  keyword      = {pulmonary function,treatment outcome,lung volume reduction surgery,chronic obstructive pulmonary disease},
  language     = {eng},
  number       = {8},
  pages        = {658--662},
  publisher    = {Chinese Medical Association},
  series       = {Chinese Medical Journal},
  title        = {Mid-term effects of lung volume reduction surgery on pulmonary function in patients with chronic obstructive pulmonary disease},
  volume       = {120},
  year         = {2007},
}