Loss of bHLH transcription factor E2A activity in primary effusion lymphoma confers resistance to apoptosis
(2007) In British Journal of Haematology 137(4). p.342-348- Abstract
- Similar to classical Hodgkin lymphoma (HL) tumour cells, primary effusion lymphoma (PEL) originates from mature B cells but displays a non-B cell phenotype, the mechanisms and consequences of which are not yet understood. This study showed that PEL lacked DNA binding activity of the B cell-determining transcription factors E2A, EBF and Pax5. PEL overexpressed the E2A antagonists ABF-1 and Id2, which have been described to block the B-cell differentiation program in classical HL. However, in contrast to HL cells, B lineage-inappropriate genes were not similarly upregulated in PEL, and reconstitution of B cell-specific E2A homodimer activity in PEL induced apoptosis. These data demonstrate that lineage infidelity in PEL is not as pronounced... (More)
- Similar to classical Hodgkin lymphoma (HL) tumour cells, primary effusion lymphoma (PEL) originates from mature B cells but displays a non-B cell phenotype, the mechanisms and consequences of which are not yet understood. This study showed that PEL lacked DNA binding activity of the B cell-determining transcription factors E2A, EBF and Pax5. PEL overexpressed the E2A antagonists ABF-1 and Id2, which have been described to block the B-cell differentiation program in classical HL. However, in contrast to HL cells, B lineage-inappropriate genes were not similarly upregulated in PEL, and reconstitution of B cell-specific E2A homodimer activity in PEL induced apoptosis. These data demonstrate that lineage infidelity in PEL is not as pronounced as in HL, and that the loss of the B cell-specific transcription factor E2A in PEL is implicated in apoptosis protection. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/663194
- author
- Lietz, Andreas ; Janz, Martin ; Sigvardsson, Mikael LU ; Jundt, Franziska ; Doerken, Bernd and Mathas, Stephan
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- E2A, lymphoma, primary effusion lymphoma, Hodgkin lymphoma
- in
- British Journal of Haematology
- volume
- 137
- issue
- 4
- pages
- 342 - 348
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000245938900008
- scopus:34247474476
- ISSN
- 0007-1048
- DOI
- 10.1111/j.1365-2141.2007.06583.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematopoietic Stem Cell Laboratory (013022012)
- id
- 771b9f7f-4223-4ec7-aee9-586580bbd1fa (old id 663194)
- date added to LUP
- 2016-04-01 12:09:04
- date last changed
- 2022-02-26 02:35:30
@article{771b9f7f-4223-4ec7-aee9-586580bbd1fa, abstract = {{Similar to classical Hodgkin lymphoma (HL) tumour cells, primary effusion lymphoma (PEL) originates from mature B cells but displays a non-B cell phenotype, the mechanisms and consequences of which are not yet understood. This study showed that PEL lacked DNA binding activity of the B cell-determining transcription factors E2A, EBF and Pax5. PEL overexpressed the E2A antagonists ABF-1 and Id2, which have been described to block the B-cell differentiation program in classical HL. However, in contrast to HL cells, B lineage-inappropriate genes were not similarly upregulated in PEL, and reconstitution of B cell-specific E2A homodimer activity in PEL induced apoptosis. These data demonstrate that lineage infidelity in PEL is not as pronounced as in HL, and that the loss of the B cell-specific transcription factor E2A in PEL is implicated in apoptosis protection.}}, author = {{Lietz, Andreas and Janz, Martin and Sigvardsson, Mikael and Jundt, Franziska and Doerken, Bernd and Mathas, Stephan}}, issn = {{0007-1048}}, keywords = {{E2A; lymphoma; primary effusion lymphoma; Hodgkin lymphoma}}, language = {{eng}}, number = {{4}}, pages = {{342--348}}, publisher = {{Wiley-Blackwell}}, series = {{British Journal of Haematology}}, title = {{Loss of bHLH transcription factor E2A activity in primary effusion lymphoma confers resistance to apoptosis}}, url = {{http://dx.doi.org/10.1111/j.1365-2141.2007.06583.x}}, doi = {{10.1111/j.1365-2141.2007.06583.x}}, volume = {{137}}, year = {{2007}}, }