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Potential and utilization of thermophiles and thermostable enzymes in biorefining

Turner, Pernilla LU ; Mamo, Gashaw LU and Nordberg Karlsson, Eva LU (2007) In Microbial Cell Factories 6.
Abstract
In today's world, there is an increasing trend towards the use of renewable, cheap and readily available biomass in the production of a wide variety of fine and bulk chemicals in different biorefineries. Biorefineries utilize the activities of microbial cells and their enzymes to convert biomass into target products. Many of these processes require enzymes which are operationally stable at high temperature thus allowing e. g. easy mixing, better substrate solubility, high mass transfer rate, and lowered risk of contamination. Thermophiles have often been proposed as sources of industrially relevant thermostable enzymes. Here we discuss existing and potential applications of thermophiles and thermostable enzymes with focus on conversion of... (More)
In today's world, there is an increasing trend towards the use of renewable, cheap and readily available biomass in the production of a wide variety of fine and bulk chemicals in different biorefineries. Biorefineries utilize the activities of microbial cells and their enzymes to convert biomass into target products. Many of these processes require enzymes which are operationally stable at high temperature thus allowing e. g. easy mixing, better substrate solubility, high mass transfer rate, and lowered risk of contamination. Thermophiles have often been proposed as sources of industrially relevant thermostable enzymes. Here we discuss existing and potential applications of thermophiles and thermostable enzymes with focus on conversion of carbohydrate containing raw materials. Their importance in biorefineries is explained using examples of lignocellulose and starch conversions to desired products. Strategies that enhance thermostablity of enzymes both in vivo and in vitro are also assessed. Moreover, this review deals with efforts made on developing vectors for expressing recombinant enzymes in thermophilic hosts. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Microbial Cell Factories
volume
6
publisher
BioMed Central
external identifiers
  • wos:000245594400001
  • scopus:34147150667
ISSN
1475-2859
DOI
10.1186/1475-2859-6-9
language
English
LU publication?
yes
id
90f9eade-f765-4a84-b237-c30162d8c4ca (old id 666377)
date added to LUP
2008-01-03 11:24:50
date last changed
2017-11-19 04:12:37
@article{90f9eade-f765-4a84-b237-c30162d8c4ca,
  abstract     = {In today's world, there is an increasing trend towards the use of renewable, cheap and readily available biomass in the production of a wide variety of fine and bulk chemicals in different biorefineries. Biorefineries utilize the activities of microbial cells and their enzymes to convert biomass into target products. Many of these processes require enzymes which are operationally stable at high temperature thus allowing e. g. easy mixing, better substrate solubility, high mass transfer rate, and lowered risk of contamination. Thermophiles have often been proposed as sources of industrially relevant thermostable enzymes. Here we discuss existing and potential applications of thermophiles and thermostable enzymes with focus on conversion of carbohydrate containing raw materials. Their importance in biorefineries is explained using examples of lignocellulose and starch conversions to desired products. Strategies that enhance thermostablity of enzymes both in vivo and in vitro are also assessed. Moreover, this review deals with efforts made on developing vectors for expressing recombinant enzymes in thermophilic hosts.},
  author       = {Turner, Pernilla and Mamo, Gashaw and Nordberg Karlsson, Eva},
  issn         = {1475-2859},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {Microbial Cell Factories},
  title        = {Potential and utilization of thermophiles and thermostable enzymes in biorefining},
  url          = {http://dx.doi.org/10.1186/1475-2859-6-9},
  volume       = {6},
  year         = {2007},
}