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1-[C-11]-acetate PET imaging in head and neck cancer - a comparison with F-18-FDG-PET: Implications for staging and radiotherapy planning

Sun, Aijun; Soerensen, Jens; Karlsson, Mikael; Turesson, Ingela; Langstroem, Bengt; Nilsson, Per LU ; Cederblad, Lena; Bertling, Jan; Riklund, Katrine and Johansson, Silvia (2007) In European Journal of Nuclear Medicine and Molecular Imaging 34(5). p.651-657
Abstract
Purpose The aim of this study was to evaluate the feasibility of using 1-[C-11]-acetate positron emission tomography (ACE-PET) to detect and delineate the gross tumour volume of head and neck cancer before radiotherapy, and to compare the results with those obtained using F-18-fluoro-2-deoxy-D-glucose (FDG) PET. Methods Ten patients with histologically verified squamous cell carcinoma were investigated by FDG-PET and dynamic ACE-PET prior to radiotherapy. The two scans were performed on the same day or on consecutive days, except in one patient in whom they were done 5 days apart. Diagnostic CT or MRI was performed in all patients. The image data sets were analysed both visually and semi-quantitatively. All primary tumours and metastases... (More)
Purpose The aim of this study was to evaluate the feasibility of using 1-[C-11]-acetate positron emission tomography (ACE-PET) to detect and delineate the gross tumour volume of head and neck cancer before radiotherapy, and to compare the results with those obtained using F-18-fluoro-2-deoxy-D-glucose (FDG) PET. Methods Ten patients with histologically verified squamous cell carcinoma were investigated by FDG-PET and dynamic ACE-PET prior to radiotherapy. The two scans were performed on the same day or on consecutive days, except in one patient in whom they were done 5 days apart. Diagnostic CT or MRI was performed in all patients. The image data sets were analysed both visually and semi-quantitatively. All primary tumours and metastases were delineated automatically by using the 50% threshold of maximum radioactivity corrected for background. The mean standardised uptake value (SUV) and the tumour volumes were evaluated and compared. Results All ten primary tumours were detected by ACE-PET, while nine primaries were detected by FDG-PET and CT and/or MRI. The ACE SUV tended to be lower than the FDG SUV (5.3 +/- 2.7 vs 9.6 +/- 7.0, p=0.07). The tumour volumes delineated with ACE were on average 51% larger than the FDG volumes (p < 0.05). ACE-PET identified 20/21 lymph node metastases, while only 13/21 lesions were detected by FDG-PET and 16/21 lesions by CT or MRI. Conclusion ACE-PET appears promising for the staging of head and neck cancer. The biological information provided by both FDG and ACE must be carefully validated before it can be used in clinical routine for radiation treatment planning. More studies are needed to evaluate the differences in volumes and to confirm the clinical potential of both FDG and ACE-PET, especially in radiotherapy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
head and neck cancer, SUV, PET, C-11-acetate, F-18-FDG
in
European Journal of Nuclear Medicine and Molecular Imaging
volume
34
issue
5
pages
651 - 657
publisher
Springer
external identifiers
  • wos:000246095900005
  • scopus:34247563467
ISSN
1619-7070
DOI
10.1007/s00259-006-0298-9
language
English
LU publication?
yes
id
581a63d8-6e00-4b51-96f8-7ceb987f2f81 (old id 666450)
date added to LUP
2008-01-03 09:04:35
date last changed
2017-01-01 04:48:54
@article{581a63d8-6e00-4b51-96f8-7ceb987f2f81,
  abstract     = {Purpose The aim of this study was to evaluate the feasibility of using 1-[C-11]-acetate positron emission tomography (ACE-PET) to detect and delineate the gross tumour volume of head and neck cancer before radiotherapy, and to compare the results with those obtained using F-18-fluoro-2-deoxy-D-glucose (FDG) PET. Methods Ten patients with histologically verified squamous cell carcinoma were investigated by FDG-PET and dynamic ACE-PET prior to radiotherapy. The two scans were performed on the same day or on consecutive days, except in one patient in whom they were done 5 days apart. Diagnostic CT or MRI was performed in all patients. The image data sets were analysed both visually and semi-quantitatively. All primary tumours and metastases were delineated automatically by using the 50% threshold of maximum radioactivity corrected for background. The mean standardised uptake value (SUV) and the tumour volumes were evaluated and compared. Results All ten primary tumours were detected by ACE-PET, while nine primaries were detected by FDG-PET and CT and/or MRI. The ACE SUV tended to be lower than the FDG SUV (5.3 +/- 2.7 vs 9.6 +/- 7.0, p=0.07). The tumour volumes delineated with ACE were on average 51% larger than the FDG volumes (p &lt; 0.05). ACE-PET identified 20/21 lymph node metastases, while only 13/21 lesions were detected by FDG-PET and 16/21 lesions by CT or MRI. Conclusion ACE-PET appears promising for the staging of head and neck cancer. The biological information provided by both FDG and ACE must be carefully validated before it can be used in clinical routine for radiation treatment planning. More studies are needed to evaluate the differences in volumes and to confirm the clinical potential of both FDG and ACE-PET, especially in radiotherapy.},
  author       = {Sun, Aijun and Soerensen, Jens and Karlsson, Mikael and Turesson, Ingela and Langstroem, Bengt and Nilsson, Per and Cederblad, Lena and Bertling, Jan and Riklund, Katrine and Johansson, Silvia},
  issn         = {1619-7070},
  keyword      = {head and neck cancer,SUV,PET,C-11-acetate,F-18-FDG},
  language     = {eng},
  number       = {5},
  pages        = {651--657},
  publisher    = {Springer},
  series       = {European Journal of Nuclear Medicine and Molecular Imaging},
  title        = {1-[C-11]-acetate PET imaging in head and neck cancer - a comparison with F-18-FDG-PET: Implications for staging and radiotherapy planning},
  url          = {http://dx.doi.org/10.1007/s00259-006-0298-9},
  volume       = {34},
  year         = {2007},
}