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Clinical radionuclide therapy dosimetry: the quest for the "Holy Gray"

Brans, B.; Bodei, L.; Giammarile, F.; Lindén, Ola LU ; Luster, M.; Oyen, W. J. G. and Tennvall, Jan LU (2007) In European Journal of Nuclear Medicine and Molecular Imaging 34(5). p.772-786
Abstract
Introduction Radionuclide therapy has distinct similarities to, but also profound differences from external radiotherapy. Review This review discusses techniques and results of previously developed dosimetry methods in thyroid carcinoma, neuro-endocrine tumours, solid tumours and lymphoma. In each case, emphasis is placed on the level of evidence and practical applicability. Although dosimetry has been of enormous value in the preclinical phase of radiopharmaceutical development, its clinical use to optimise administered activity on an individual patient basis has been less evident. In phase I and II trials, dosimetry may be considered an inherent part of therapy to establish the maximum tolerated dose and dose-response relationship. To... (More)
Introduction Radionuclide therapy has distinct similarities to, but also profound differences from external radiotherapy. Review This review discusses techniques and results of previously developed dosimetry methods in thyroid carcinoma, neuro-endocrine tumours, solid tumours and lymphoma. In each case, emphasis is placed on the level of evidence and practical applicability. Although dosimetry has been of enormous value in the preclinical phase of radiopharmaceutical development, its clinical use to optimise administered activity on an individual patient basis has been less evident. In phase I and II trials, dosimetry may be considered an inherent part of therapy to establish the maximum tolerated dose and dose-response relationship. To prove that dosimetry-based radionuclide therapy is of additional benefit over fixed dosing or dosing per kilogram body weight, prospective randomised phase III trials with appropriate end points have to be undertaken. Data in the literature which underscore the potential of dosimetry to avoid under- and overdosing and to standardise radionuclide therapy methods internationally are very scarce. Developments In each section, particular developments and insights into these therapies are related to opportunities for dosimetry. The recent developments in PET and PET/CT imaging, including micro-devices for animal research, and molecular medicine provide major challenges for innovative therapy and dosimetry techniques. Furthermore, the increasing scientific interest in the radiobiological features specific to radionuclide therapy will advance our ability to administer this treatment modality optimally. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
radio-immunotherapy, neuro-endocrine tumours, carcinoma, thyroid, radiotherapy, radionuclide therapy, radiation dosimetry, solid tumours, lymphoma
in
European Journal of Nuclear Medicine and Molecular Imaging
volume
34
issue
5
pages
772 - 786
publisher
Springer
external identifiers
  • wos:000246095900018
  • scopus:34247570013
ISSN
1619-7070
DOI
10.1007/s00259-006-0338-5
language
English
LU publication?
yes
id
d717c64d-c3f1-4690-a772-1f4a49203546 (old id 666461)
date added to LUP
2007-12-11 15:42:29
date last changed
2017-10-29 03:24:23
@article{d717c64d-c3f1-4690-a772-1f4a49203546,
  abstract     = {Introduction Radionuclide therapy has distinct similarities to, but also profound differences from external radiotherapy. Review This review discusses techniques and results of previously developed dosimetry methods in thyroid carcinoma, neuro-endocrine tumours, solid tumours and lymphoma. In each case, emphasis is placed on the level of evidence and practical applicability. Although dosimetry has been of enormous value in the preclinical phase of radiopharmaceutical development, its clinical use to optimise administered activity on an individual patient basis has been less evident. In phase I and II trials, dosimetry may be considered an inherent part of therapy to establish the maximum tolerated dose and dose-response relationship. To prove that dosimetry-based radionuclide therapy is of additional benefit over fixed dosing or dosing per kilogram body weight, prospective randomised phase III trials with appropriate end points have to be undertaken. Data in the literature which underscore the potential of dosimetry to avoid under- and overdosing and to standardise radionuclide therapy methods internationally are very scarce. Developments In each section, particular developments and insights into these therapies are related to opportunities for dosimetry. The recent developments in PET and PET/CT imaging, including micro-devices for animal research, and molecular medicine provide major challenges for innovative therapy and dosimetry techniques. Furthermore, the increasing scientific interest in the radiobiological features specific to radionuclide therapy will advance our ability to administer this treatment modality optimally.},
  author       = {Brans, B. and Bodei, L. and Giammarile, F. and Lindén, Ola and Luster, M. and Oyen, W. J. G. and Tennvall, Jan},
  issn         = {1619-7070},
  keyword      = {radio-immunotherapy,neuro-endocrine tumours,carcinoma,thyroid,radiotherapy,radionuclide therapy,radiation dosimetry,solid tumours,lymphoma},
  language     = {eng},
  number       = {5},
  pages        = {772--786},
  publisher    = {Springer},
  series       = {European Journal of Nuclear Medicine and Molecular Imaging},
  title        = {Clinical radionuclide therapy dosimetry: the quest for the "Holy Gray"},
  url          = {http://dx.doi.org/10.1007/s00259-006-0338-5},
  volume       = {34},
  year         = {2007},
}