Haptoglobin: the hemoglobin detoxifier in plasma
(2013) In Trends in Biotechnology 31(1). p.2-3- Abstract
- Hemoglobin (Hb) is one of the most studied proteins. However, oxidative toxicity associated with free Hb in circulation and its contribution to inflammation and complications of transfusion have only recently become active areas of research. New insights into the protective mechanisms of haptoglobin (Hp), a plasma protein, and a timely resolution of the crystal structure of the Hb-Hp complex made it possible to definitively link the functional and structural interplay between the two proteins. Here, we summarize current knowledge of the interactions between Hb and Hp under oxidative stress conditions, and how Hb's own damaging radicals are harnessed by complex formation. Potential therapeutic benefits of using Hp for inactivation and... (More)
- Hemoglobin (Hb) is one of the most studied proteins. However, oxidative toxicity associated with free Hb in circulation and its contribution to inflammation and complications of transfusion have only recently become active areas of research. New insights into the protective mechanisms of haptoglobin (Hp), a plasma protein, and a timely resolution of the crystal structure of the Hb-Hp complex made it possible to definitively link the functional and structural interplay between the two proteins. Here, we summarize current knowledge of the interactions between Hb and Hp under oxidative stress conditions, and how Hb's own damaging radicals are harnessed by complex formation. Potential therapeutic benefits of using Hp for inactivation and clearance of free Hb under a number of clinical settings are considered. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3596063
- author
- Alayash, Abdu I. ; Andersen, Christian Brix Folsted ; Moestrup, Soren Kragh and Bülow, Leif LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Biotechnology
- volume
- 31
- issue
- 1
- pages
- 2 - 3
- publisher
- Elsevier
- external identifiers
-
- wos:000314014600002
- scopus:84871699041
- ISSN
- 0167-7799
- DOI
- 10.1016/j.tibtech.2012.10.003
- language
- English
- LU publication?
- yes
- id
- 6668ea8f-cf39-406e-b15f-a70e87a108bf (old id 3596063)
- date added to LUP
- 2016-04-01 10:24:24
- date last changed
- 2022-01-25 22:52:34
@article{6668ea8f-cf39-406e-b15f-a70e87a108bf,
abstract = {{Hemoglobin (Hb) is one of the most studied proteins. However, oxidative toxicity associated with free Hb in circulation and its contribution to inflammation and complications of transfusion have only recently become active areas of research. New insights into the protective mechanisms of haptoglobin (Hp), a plasma protein, and a timely resolution of the crystal structure of the Hb-Hp complex made it possible to definitively link the functional and structural interplay between the two proteins. Here, we summarize current knowledge of the interactions between Hb and Hp under oxidative stress conditions, and how Hb's own damaging radicals are harnessed by complex formation. Potential therapeutic benefits of using Hp for inactivation and clearance of free Hb under a number of clinical settings are considered.}},
author = {{Alayash, Abdu I. and Andersen, Christian Brix Folsted and Moestrup, Soren Kragh and Bülow, Leif}},
issn = {{0167-7799}},
language = {{eng}},
number = {{1}},
pages = {{2--3}},
publisher = {{Elsevier}},
series = {{Trends in Biotechnology}},
title = {{Haptoglobin: the hemoglobin detoxifier in plasma}},
url = {{http://dx.doi.org/10.1016/j.tibtech.2012.10.003}},
doi = {{10.1016/j.tibtech.2012.10.003}},
volume = {{31}},
year = {{2013}},
}