Plasma Protein Layer Concealment Protects Streptococcus pyogenes From Innate Immune Attack
Jagau, Hilger LU ; Packirisamy, Swathi LU
; Brandon, Kyle
and Herwald, Heiko
LU
(2021)
In Frontiers in cellular and infection microbiology
11.
- Abstract
Early recognition and elimination of invading pathogens by the innate immune system, is one of the most efficient host defense mechanisms preventing the induction of systemic complications from infection. To this end the host can mobilize endogenous antimicrobials capable of killing the intruder by perforating the microbial cell wall. Here, we show that Streptococcus pyogenes can shield its outer surface with a layer of plasma proteins. This mechanism protects the bacteria from an otherwise lytic attack by LL-37 and extracellular histones, allowing the bacteria to adjust their gene regulation to an otherwise hostile environment.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/66eaea58-1a00-424a-a108-e9a8738e7226
- author
- Jagau, Hilger
LU
; Packirisamy, Swathi
LU
; Brandon, Kyle
and Herwald, Heiko
LU
- organization
- publishing date
- 2021-05-20
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- antibiotic resistance, antimicrobials, cold atmospheric plasma (CAP), hemostasis, innate immune system, Streptococcus pyogenes (GAS)
- in
- Frontiers in cellular and infection microbiology
- volume
- 11
- article number
- 633394
- publisher
- Frontiers Media S. A.
- external identifiers
-
- pmid:34094995
- scopus:85107302744
- ISSN
- 2235-2988
- DOI
- 10.3389/fcimb.2021.633394
- language
- English
- LU publication?
- yes
- id
- 66eaea58-1a00-424a-a108-e9a8738e7226
- date added to LUP
- 2021-06-24 10:23:16
- date last changed
- 2024-06-01 12:10:40
@article{66eaea58-1a00-424a-a108-e9a8738e7226,
abstract = {{<p>Early recognition and elimination of invading pathogens by the innate immune system, is one of the most efficient host defense mechanisms preventing the induction of systemic complications from infection. To this end the host can mobilize endogenous antimicrobials capable of killing the intruder by perforating the microbial cell wall. Here, we show that Streptococcus pyogenes can shield its outer surface with a layer of plasma proteins. This mechanism protects the bacteria from an otherwise lytic attack by LL-37 and extracellular histones, allowing the bacteria to adjust their gene regulation to an otherwise hostile environment.</p>}},
author = {{Jagau, Hilger and Packirisamy, Swathi and Brandon, Kyle and Herwald, Heiko}},
issn = {{2235-2988}},
keywords = {{antibiotic resistance; antimicrobials; cold atmospheric plasma (CAP); hemostasis; innate immune system; Streptococcus pyogenes (GAS)}},
language = {{eng}},
month = {{05}},
publisher = {{Frontiers Media S. A.}},
series = {{Frontiers in cellular and infection microbiology}},
title = {{Plasma Protein Layer Concealment Protects Streptococcus pyogenes From Innate Immune Attack}},
url = {{http://dx.doi.org/10.3389/fcimb.2021.633394}},
doi = {{10.3389/fcimb.2021.633394}},
volume = {{11}},
year = {{2021}},
}