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Arynes in the Monoarylation of Unprotected Carbohydrate Amines

Pal, Kumar Bhaskar; Mahanti, Mukul LU and Nilsson, Ulf J. LU (2018) In Organic Letters 20(3). p.616-619
Abstract

A CsF-mediated method has been developed for the N-arylation of amino sugars that affords good to excellent yields of arylated products under mild conditions involving the in situ generation of arynes. The reaction conditions tolerate a variety of common carbohydrate protecting groups and also performs exceptionally well on unprotected amino sugar derivatives. The reactions are scalable in moderate to good yields with broad scope.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Organic Letters
volume
20
issue
3
pages
4 pages
publisher
The American Chemical Society
external identifiers
  • scopus:85041603885
ISSN
1523-7060
DOI
10.1021/acs.orglett.7b03741
language
English
LU publication?
yes
id
66fb37bb-e697-48a1-9afc-d5ceebfc11c1
date added to LUP
2018-02-21 10:03:56
date last changed
2018-07-08 04:30:07
@article{66fb37bb-e697-48a1-9afc-d5ceebfc11c1,
  abstract     = {<p>A CsF-mediated method has been developed for the N-arylation of amino sugars that affords good to excellent yields of arylated products under mild conditions involving the in situ generation of arynes. The reaction conditions tolerate a variety of common carbohydrate protecting groups and also performs exceptionally well on unprotected amino sugar derivatives. The reactions are scalable in moderate to good yields with broad scope.</p>},
  author       = {Pal, Kumar Bhaskar and Mahanti, Mukul and Nilsson, Ulf J.},
  issn         = {1523-7060},
  language     = {eng},
  month        = {02},
  number       = {3},
  pages        = {616--619},
  publisher    = {The American Chemical Society},
  series       = {Organic Letters},
  title        = {Arynes in the Monoarylation of Unprotected Carbohydrate Amines},
  url          = {http://dx.doi.org/10.1021/acs.orglett.7b03741},
  volume       = {20},
  year         = {2018},
}