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A fatty acid-rich fraction of an endolichenic fungus Phoma sp. suppresses immune checkpoint markers via AhR/ARNT and ESR1

Varlı, Mücahit ; Ngo, Men Thi ; Kim, Seong-Min ; Taş, İsa LU orcid ; Zhou, Rui ; Gamage, Chathurika D B ; Pulat, Sultan ; Park, So-Yeon ; Sesal, Nüzhet Cenk and Hur, Jae-Seoun , et al. (2023) In Heliyon 9(9).
Abstract

Lung cancer has the highest mortality rates worldwide. The disease is caused by environmental pollutants, smoking, and many other factors. Recent treatments include immunotherapeutics, which have shown some success; however, the search for new therapeutics is ongoing. Endolichenic fungi produce a whale of a lot of secondary metabolites, the therapeutic effects of which are being evaluated. Here, we used a crude extract and subfractions of the endolichenic fungus, Phoma sp. (EL006848), isolated from the Pseudevernia furfuracea. It was identified the fatty acid components, palmitic acid, stearic acid, and oleic acid, exist in subfractions E1 and E2. In addition, EL006848 and its fatty acids fractions suppressed benzo[a]pyrene (an AhR... (More)

Lung cancer has the highest mortality rates worldwide. The disease is caused by environmental pollutants, smoking, and many other factors. Recent treatments include immunotherapeutics, which have shown some success; however, the search for new therapeutics is ongoing. Endolichenic fungi produce a whale of a lot of secondary metabolites, the therapeutic effects of which are being evaluated. Here, we used a crude extract and subfractions of the endolichenic fungus, Phoma sp. (EL006848), isolated from the Pseudevernia furfuracea. It was identified the fatty acid components, palmitic acid, stearic acid, and oleic acid, exist in subfractions E1 and E2. In addition, EL006848 and its fatty acids fractions suppressed benzo[a]pyrene (an AhR ligand)- induced expression of PD-L1 to inhibit the activity of multiple immune checkpoints. E2 subfraction, which had a higher fatty acid content than E1, downregulated expression of AhR/ARNT and several human transcription factors related to ESR1. Moreover, E2 showed a strong inhibitory effect on STAT3 expression and mild effect on NF-kB activity. These results suggest that fatty acids extracted from an endolichenic fungus can exert strong immunotherapeutic effects.

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publishing date
type
Contribution to journal
publication status
published
in
Heliyon
volume
9
issue
9
article number
e19185
publisher
Elsevier
external identifiers
  • scopus:85172701491
  • pmid:37662726
ISSN
2405-8440
DOI
10.1016/j.heliyon.2023.e19185
language
English
LU publication?
no
additional info
© 2023 The Authors.
id
66fe8f12-d4d6-4449-b54e-cfa9324cadf9
date added to LUP
2026-09-23 16:00:12
date last changed
2026-09-24 04:01:33
@article{66fe8f12-d4d6-4449-b54e-cfa9324cadf9,
  abstract     = {{<p>Lung cancer has the highest mortality rates worldwide. The disease is caused by environmental pollutants, smoking, and many other factors. Recent treatments include immunotherapeutics, which have shown some success; however, the search for new therapeutics is ongoing. Endolichenic fungi produce a whale of a lot of secondary metabolites, the therapeutic effects of which are being evaluated. Here, we used a crude extract and subfractions of the endolichenic fungus, Phoma sp. (EL006848), isolated from the Pseudevernia furfuracea. It was identified the fatty acid components, palmitic acid, stearic acid, and oleic acid, exist in subfractions E1 and E2. In addition, EL006848 and its fatty acids fractions suppressed benzo[a]pyrene (an AhR ligand)- induced expression of PD-L1 to inhibit the activity of multiple immune checkpoints. E2 subfraction, which had a higher fatty acid content than E1, downregulated expression of AhR/ARNT and several human transcription factors related to ESR1. Moreover, E2 showed a strong inhibitory effect on STAT3 expression and mild effect on NF-kB activity. These results suggest that fatty acids extracted from an endolichenic fungus can exert strong immunotherapeutic effects.</p>}},
  author       = {{Varlı, Mücahit and Ngo, Men Thi and Kim, Seong-Min and Taş, İsa and Zhou, Rui and Gamage, Chathurika D B and Pulat, Sultan and Park, So-Yeon and Sesal, Nüzhet Cenk and Hur, Jae-Seoun and Kang, Kyo Bin and Kim, Hangun}},
  issn         = {{2405-8440}},
  language     = {{eng}},
  number       = {{9}},
  publisher    = {{Elsevier}},
  series       = {{Heliyon}},
  title        = {{A fatty acid-rich fraction of an endolichenic fungus Phoma sp. suppresses immune checkpoint markers via AhR/ARNT and ESR1}},
  url          = {{http://dx.doi.org/10.1016/j.heliyon.2023.e19185}},
  doi          = {{10.1016/j.heliyon.2023.e19185}},
  volume       = {{9}},
  year         = {{2023}},
}