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Weight development in patients treated with risperidone: a 5-year naturalistic study

Neovius, M.; Eberhard, Jonas LU ; Lindstrom, E. and Levander, Sten LU (2007) In Acta Psychiatrica Scandinavica 115(4). p.277-285
Abstract
Objective: To examine annual weight-development in a sample of 215 psychotic patients treated with risperidone over 5 years. Method: Naturalistic longitudinal study. Results: The sample was more obese than the general population at baseline, but also increased much more in mean body mass index over approximately the same time period, while patients off medication seemed to remain weight stable. Excessive weight gain (> 7%) was experienced by 40.2% and was weakly associated with weight at baseline (beta = -0.2%; P = 0.02), while independent of gender, symptoms, years of illness, prolactin levels and nicotine consumption. In patients with complete weight data (n = 87), approximately 72% (3.4 +/- 8.3 kg) of the observed 5 years weight gain... (More)
Objective: To examine annual weight-development in a sample of 215 psychotic patients treated with risperidone over 5 years. Method: Naturalistic longitudinal study. Results: The sample was more obese than the general population at baseline, but also increased much more in mean body mass index over approximately the same time period, while patients off medication seemed to remain weight stable. Excessive weight gain (> 7%) was experienced by 40.2% and was weakly associated with weight at baseline (beta = -0.2%; P = 0.02), while independent of gender, symptoms, years of illness, prolactin levels and nicotine consumption. In patients with complete weight data (n = 87), approximately 72% (3.4 +/- 8.3 kg) of the observed 5 years weight gain (4.7 +/- 11.6 kg) had been accumulated after 2 years. Conclusion: Antipsychotic drug treatment resulted in significant weight gain, which levelled off over time. Unfortunately, few significant predictors of adverse weight development could be identified, leaving little guidance for clinical decision making regarding this specific side-effect. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
naturalistic, longitudinal, antipsychotics, body mass index, schizophrenia, weight
in
Acta Psychiatrica Scandinavica
volume
115
issue
4
pages
277 - 285
publisher
Wiley-Blackwell
external identifiers
  • wos:000244877800004
  • scopus:33947280135
ISSN
1600-0447
DOI
10.1111/j.1600-0447.2006.00899.x
language
English
LU publication?
yes
id
626c3a2f-5ac1-4af4-b82f-c962a2fcef16 (old id 670339)
date added to LUP
2007-12-17 10:37:43
date last changed
2017-08-09 14:39:36
@article{626c3a2f-5ac1-4af4-b82f-c962a2fcef16,
  abstract     = {Objective: To examine annual weight-development in a sample of 215 psychotic patients treated with risperidone over 5 years. Method: Naturalistic longitudinal study. Results: The sample was more obese than the general population at baseline, but also increased much more in mean body mass index over approximately the same time period, while patients off medication seemed to remain weight stable. Excessive weight gain (> 7%) was experienced by 40.2% and was weakly associated with weight at baseline (beta = -0.2%; P = 0.02), while independent of gender, symptoms, years of illness, prolactin levels and nicotine consumption. In patients with complete weight data (n = 87), approximately 72% (3.4 +/- 8.3 kg) of the observed 5 years weight gain (4.7 +/- 11.6 kg) had been accumulated after 2 years. Conclusion: Antipsychotic drug treatment resulted in significant weight gain, which levelled off over time. Unfortunately, few significant predictors of adverse weight development could be identified, leaving little guidance for clinical decision making regarding this specific side-effect.},
  author       = {Neovius, M. and Eberhard, Jonas and Lindstrom, E. and Levander, Sten},
  issn         = {1600-0447},
  keyword      = {naturalistic,longitudinal,antipsychotics,body mass index,schizophrenia,weight},
  language     = {eng},
  number       = {4},
  pages        = {277--285},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Psychiatrica Scandinavica},
  title        = {Weight development in patients treated with risperidone: a 5-year naturalistic study},
  url          = {http://dx.doi.org/10.1111/j.1600-0447.2006.00899.x},
  volume       = {115},
  year         = {2007},
}