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Sustained intravascular exposure to propofol does not prolong pain at the site of injection

Liljeroth, Elisabeth LU ; Karlsson, A.; Lagerkranser, M. and Åkeson, Jonas LU (2007) In Acta Anaesthesiologica Scandinavica 51(4). p.456-459
Abstract
Background Pain at the site of intravenous injection of propofol is a common clinical finding. This double-blind, randomized cross-over study was designed to evaluate whether venous occlusion applied during injection of a low dose of propofol reduces the intensity of pain at the site of injection compared with no occlusion. Methods Bilateral 0.5-ml injections of an emulsion containing 10 mg/ml of propofol were given over 30 s in 75 adult surgical patients. Each patient was given one injection with and one without 60-s occlusion of the cannulated vein with a 10-min interval, and asked to score the maximal pain intensity on a visual analogue scale (VAS). Results The maximal pain intensity [median (25th percentile; 75th percentile), range] at... (More)
Background Pain at the site of intravenous injection of propofol is a common clinical finding. This double-blind, randomized cross-over study was designed to evaluate whether venous occlusion applied during injection of a low dose of propofol reduces the intensity of pain at the site of injection compared with no occlusion. Methods Bilateral 0.5-ml injections of an emulsion containing 10 mg/ml of propofol were given over 30 s in 75 adult surgical patients. Each patient was given one injection with and one without 60-s occlusion of the cannulated vein with a 10-min interval, and asked to score the maximal pain intensity on a visual analogue scale (VAS). Results The maximal pain intensity [median (25th percentile; 75th percentile), range] at the site of injection was 0.5 (0; 3.5), 0-8.0 VAS units with venous occlusion and 0.5 (0; 1.4), 0-6.0 VAS units without occlusion (P = 0.042). Pain was first reported within 20 s regardless of the study regimen and was not prolonged by local venous occlusion. Conclusions Venous occlusion augments pain intensity at the site of propofol injection without prolonging pain, implying that propofol-induced pain is determined more by the blood concentration than by the duration of intravascular exposure. The low intensity of pain induced by low-dose propofol and the fading of pain despite sustained exposure suggest that initial low-dose administration of propofol should be evaluated for the attenuation of local pain induced by higher intravenous doses of propofol. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
propofol, pain, intravenous anaesthesia/anaesthetics, dose fractionation, injection, tourniquet, venous occlusion, visual analogue scale
in
Acta Anaesthesiologica Scandinavica
volume
51
issue
4
pages
456 - 459
publisher
Wiley-Blackwell
external identifiers
  • wos:000244877500011
  • scopus:33947285822
ISSN
0001-5172
DOI
10.1111/j.1399-6576.2006.01256.x
language
English
LU publication?
yes
id
993c780d-b9a5-40d3-94c9-66d89b2e06f3 (old id 670898)
date added to LUP
2007-12-12 14:45:04
date last changed
2017-01-01 04:25:08
@article{993c780d-b9a5-40d3-94c9-66d89b2e06f3,
  abstract     = {Background Pain at the site of intravenous injection of propofol is a common clinical finding. This double-blind, randomized cross-over study was designed to evaluate whether venous occlusion applied during injection of a low dose of propofol reduces the intensity of pain at the site of injection compared with no occlusion. Methods Bilateral 0.5-ml injections of an emulsion containing 10 mg/ml of propofol were given over 30 s in 75 adult surgical patients. Each patient was given one injection with and one without 60-s occlusion of the cannulated vein with a 10-min interval, and asked to score the maximal pain intensity on a visual analogue scale (VAS). Results The maximal pain intensity [median (25th percentile; 75th percentile), range] at the site of injection was 0.5 (0; 3.5), 0-8.0 VAS units with venous occlusion and 0.5 (0; 1.4), 0-6.0 VAS units without occlusion (P = 0.042). Pain was first reported within 20 s regardless of the study regimen and was not prolonged by local venous occlusion. Conclusions Venous occlusion augments pain intensity at the site of propofol injection without prolonging pain, implying that propofol-induced pain is determined more by the blood concentration than by the duration of intravascular exposure. The low intensity of pain induced by low-dose propofol and the fading of pain despite sustained exposure suggest that initial low-dose administration of propofol should be evaluated for the attenuation of local pain induced by higher intravenous doses of propofol.},
  author       = {Liljeroth, Elisabeth and Karlsson, A. and Lagerkranser, M. and Åkeson, Jonas},
  issn         = {0001-5172},
  keyword      = {propofol,pain,intravenous anaesthesia/anaesthetics,dose fractionation,injection,tourniquet,venous occlusion,visual analogue scale},
  language     = {eng},
  number       = {4},
  pages        = {456--459},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Anaesthesiologica Scandinavica},
  title        = {Sustained intravascular exposure to propofol does not prolong pain at the site of injection},
  url          = {http://dx.doi.org/10.1111/j.1399-6576.2006.01256.x},
  volume       = {51},
  year         = {2007},
}