Low-dose propofol reduces the incidence of moderate to severe local pain induced by the main dose
(2007) In Acta Anaesthesiologica Scandinavica 51(4). p.460-463- Abstract
- Background Local pain on injection of propofol remains a considerable problem in clinical anaesthesiology. As slow infusion of a low dose of propofol induces little or no pain at the site of injection, and as propofol-induced pain fades during prolonged exposure, this randomized, double-blind, clinical cross-over study was designed to test whether pain on injection of propofol is attenuated by initial slow injection of a low dose of propofol by the same intravenous line. Methods Seventy-seven adult surgical patients were cannulated in a dorsal vein on each hand. In each cannula, a 0.5-ml priming dose of either propofol 10 mg/ml dissolved in an emulsion of medium- and long-chain triglycerides or aqueous sodium chloride 9.0 mg/ml was... (More)
- Background Local pain on injection of propofol remains a considerable problem in clinical anaesthesiology. As slow infusion of a low dose of propofol induces little or no pain at the site of injection, and as propofol-induced pain fades during prolonged exposure, this randomized, double-blind, clinical cross-over study was designed to test whether pain on injection of propofol is attenuated by initial slow injection of a low dose of propofol by the same intravenous line. Methods Seventy-seven adult surgical patients were cannulated in a dorsal vein on each hand. In each cannula, a 0.5-ml priming dose of either propofol 10 mg/ml dissolved in an emulsion of medium- and long-chain triglycerides or aqueous sodium chloride 9.0 mg/ml was injected over 30 s, and followed 120 s later by a main dose of 2.0 ml of the same propofol formula over 6 s. After each injection, the patients were asked by a blind investigator to score the maximal pain intensity on a visual analogue scale (VAS). Results Although the decrease in maximal pain intensity did not reach statistical significance (P = 0.070), significantly fewer patients reported moderate or severe pain intensity (corresponding to 3.0 VAS units or more) after the main dose of propofol was preceded by a priming dose of propofol than by sodium chloride (P = 0.041). Conclusions The incidence of moderate to severe local pain induced by intravenous propofol can be decreased by a readily applicable technique in which a low dose of propofol emulsion is slowly administered by the same intravenous route 2 min in advance. (Less)
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https://lup.lub.lu.se/record/670903
- author
- Liljeroth, E. ; Karlsson, A. ; Lagerkranser, M. and Åkeson, Jonas LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- visual analogue scale, propofol, pain, intravenous anaesthesia/anaesthetics, dose fractionation, injection
- in
- Acta Anaesthesiologica Scandinavica
- volume
- 51
- issue
- 4
- pages
- 460 - 463
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000244877500012
- scopus:33947285156
- ISSN
- 0001-5172
- DOI
- 10.1111/j.1399-6576.2006.01255.x
- language
- English
- LU publication?
- yes
- id
- 10d75a05-9641-4d51-8a76-8e2fb66352b3 (old id 670903)
- date added to LUP
- 2016-04-01 11:36:14
- date last changed
- 2022-01-26 07:26:23
@article{10d75a05-9641-4d51-8a76-8e2fb66352b3,
abstract = {{Background Local pain on injection of propofol remains a considerable problem in clinical anaesthesiology. As slow infusion of a low dose of propofol induces little or no pain at the site of injection, and as propofol-induced pain fades during prolonged exposure, this randomized, double-blind, clinical cross-over study was designed to test whether pain on injection of propofol is attenuated by initial slow injection of a low dose of propofol by the same intravenous line. Methods Seventy-seven adult surgical patients were cannulated in a dorsal vein on each hand. In each cannula, a 0.5-ml priming dose of either propofol 10 mg/ml dissolved in an emulsion of medium- and long-chain triglycerides or aqueous sodium chloride 9.0 mg/ml was injected over 30 s, and followed 120 s later by a main dose of 2.0 ml of the same propofol formula over 6 s. After each injection, the patients were asked by a blind investigator to score the maximal pain intensity on a visual analogue scale (VAS). Results Although the decrease in maximal pain intensity did not reach statistical significance (P = 0.070), significantly fewer patients reported moderate or severe pain intensity (corresponding to 3.0 VAS units or more) after the main dose of propofol was preceded by a priming dose of propofol than by sodium chloride (P = 0.041). Conclusions The incidence of moderate to severe local pain induced by intravenous propofol can be decreased by a readily applicable technique in which a low dose of propofol emulsion is slowly administered by the same intravenous route 2 min in advance.}},
author = {{Liljeroth, E. and Karlsson, A. and Lagerkranser, M. and Åkeson, Jonas}},
issn = {{0001-5172}},
keywords = {{visual analogue scale; propofol; pain; intravenous anaesthesia/anaesthetics; dose fractionation; injection}},
language = {{eng}},
number = {{4}},
pages = {{460--463}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Anaesthesiologica Scandinavica}},
title = {{Low-dose propofol reduces the incidence of moderate to severe local pain induced by the main dose}},
url = {{http://dx.doi.org/10.1111/j.1399-6576.2006.01255.x}},
doi = {{10.1111/j.1399-6576.2006.01255.x}},
volume = {{51}},
year = {{2007}},
}