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Occupational exposure to NDMA and NMor in the European rubber industry

de Vocht, F.; Burstyn, I.; Straif, K.; Vermeulen, R.; Jakobsson, Kristina LU ; Nichols, L.; Peplonska, B.; Taeger, D. and Kromhout, H. (2007) In Journal of Environmental Monitoring 9(3). p.253-259
Abstract
Many nitrosamines are suspected of being human carcinogens, with the highest concentrations in the environment being measured in the rubber industry. Time trends of personal exposure to N-nitrosodimethylamine (NDMA) and to N-nitrosomorpholine (NMor) during the past two decades in the German rubber industry were analysed and compared with cross-sectional studies in the same period in the Netherlands, Poland, the UK and Sweden. In the majority of the surveyed departments exposures reduced over time, but considerable heterogeneity was present between departments and sectors. Significant reductions were primarily found in curing and post-treating departments and ranged from -3% year(-1) to -19% year(-1). In contrast, NDMA levels increased (+... (More)
Many nitrosamines are suspected of being human carcinogens, with the highest concentrations in the environment being measured in the rubber industry. Time trends of personal exposure to N-nitrosodimethylamine (NDMA) and to N-nitrosomorpholine (NMor) during the past two decades in the German rubber industry were analysed and compared with cross-sectional studies in the same period in the Netherlands, Poland, the UK and Sweden. In the majority of the surveyed departments exposures reduced over time, but considerable heterogeneity was present between departments and sectors. Significant reductions were primarily found in curing and post-treating departments and ranged from -3% year(-1) to -19% year(-1). In contrast, NDMA levels increased (+ 13% year(-1)) in maintenance and engineering in the tyres industry. Average NDMA-levels in general rubber goods (GRG) and NMor-levels in tyre production in Germany did not decrease significantly in the past two decades, whereas NDMA-levels in tyre production (-10% year(-1)) and NMor-levels in GRG (-7% year(-1)) declined significantly after the introduction of an exposure limit for total nitrosamines in Germany in 1988. Confidence intervals of average exposures in other studied countries largely overlap trends observed in Germany. Exposure to N-nitrosamines decreased on average two-to-five fold in the German rubber industry with comparable concentration levels in other European countries. Although average levels are well below the current limits exposure has not been eliminated, and incidental high exposures do still occur. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
keywords
Occupational/analysis* *Confidence Intervals *Cross-Sectional Studies *Dimethylnitrosamine *Europe *Humans *Industry* *Nitrosamines/adverse effects *Nitrosamines/analysis* *Occupational Diseases/prevention & control *Rubber/adverse effects*, *Air Pollutants
in
Journal of Environmental Monitoring
volume
9
issue
3
pages
253 - 259
publisher
Royal Society of Chemistry
external identifiers
  • wos:000244738700005
  • scopus:33847736287
ISSN
1464-0325
DOI
10.1039/b615472g
language
English
LU publication?
yes
id
0251b705-b0a6-493a-98cc-4abece65b08a (old id 671642)
alternative location
http://pubs.rsc.org/en/Content/ArticleLanding/2007/EM/b615472g
date added to LUP
2007-12-11 11:19:21
date last changed
2017-04-30 08:36:17
@article{0251b705-b0a6-493a-98cc-4abece65b08a,
  abstract     = {Many nitrosamines are suspected of being human carcinogens, with the highest concentrations in the environment being measured in the rubber industry. Time trends of personal exposure to N-nitrosodimethylamine (NDMA) and to N-nitrosomorpholine (NMor) during the past two decades in the German rubber industry were analysed and compared with cross-sectional studies in the same period in the Netherlands, Poland, the UK and Sweden. In the majority of the surveyed departments exposures reduced over time, but considerable heterogeneity was present between departments and sectors. Significant reductions were primarily found in curing and post-treating departments and ranged from -3% year(-1) to -19% year(-1). In contrast, NDMA levels increased (+ 13% year(-1)) in maintenance and engineering in the tyres industry. Average NDMA-levels in general rubber goods (GRG) and NMor-levels in tyre production in Germany did not decrease significantly in the past two decades, whereas NDMA-levels in tyre production (-10% year(-1)) and NMor-levels in GRG (-7% year(-1)) declined significantly after the introduction of an exposure limit for total nitrosamines in Germany in 1988. Confidence intervals of average exposures in other studied countries largely overlap trends observed in Germany. Exposure to N-nitrosamines decreased on average two-to-five fold in the German rubber industry with comparable concentration levels in other European countries. Although average levels are well below the current limits exposure has not been eliminated, and incidental high exposures do still occur.},
  author       = {de Vocht, F. and Burstyn, I. and Straif, K. and Vermeulen, R. and Jakobsson, Kristina and Nichols, L. and Peplonska, B. and Taeger, D. and Kromhout, H.},
  issn         = {1464-0325},
  keyword      = {Occupational/analysis* *Confidence Intervals *Cross-Sectional Studies *Dimethylnitrosamine *Europe *Humans *Industry* *Nitrosamines/adverse effects *Nitrosamines/analysis* *Occupational Diseases/prevention & control *Rubber/adverse effects*,*Air Pollutants},
  language     = {eng},
  number       = {3},
  pages        = {253--259},
  publisher    = {Royal Society of Chemistry},
  series       = {Journal of Environmental Monitoring},
  title        = {Occupational exposure to NDMA and NMor in the European rubber industry},
  url          = {http://dx.doi.org/10.1039/b615472g},
  volume       = {9},
  year         = {2007},
}