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Intestinal fatty acid binding protein as a marker of necrosis and severity in acute pancreatitis

Kupčinskas, Juozas; Gedgaudas, Rolandas; Hartman, Hannes LU ; Sippola, Tomi; Lindström, Outi; Johnson, Colin D. and Regnér, Sara LU (2018) In Pancreas 47(6). p.715-720
Abstract

Objectives The aim of this study was to study intestinal fatty acid binding protein (i-FABP) as a potential biomarker in predicting severity of acute pancreatitis (AP). Methods In a prospective multicenter cohort study, plasma levels of i-FABP were measured in 402 patients with AP. Severity of AP was determined based on the 1992 Atlanta Classification. Results Admission levels of plasma i-FABP were significantly higher in patients with pancreatic necrosis, in patients having systemic complications, in patients treated invasively, in patients treated in the intensive care unit, in patients with severe AP, and in deceased patients. Plasma i-FABP levels on admission yielded an area under curve (AUC) of 0.732 in discriminating patients with... (More)

Objectives The aim of this study was to study intestinal fatty acid binding protein (i-FABP) as a potential biomarker in predicting severity of acute pancreatitis (AP). Methods In a prospective multicenter cohort study, plasma levels of i-FABP were measured in 402 patients with AP. Severity of AP was determined based on the 1992 Atlanta Classification. Results Admission levels of plasma i-FABP were significantly higher in patients with pancreatic necrosis, in patients having systemic complications, in patients treated invasively, in patients treated in the intensive care unit, in patients with severe AP, and in deceased patients. Plasma i-FABP levels on admission yielded an area under curve (AUC) of 0.732 in discriminating patients with or without pancreatic necrosis and AUC of 0.669 in predicting severe AP. Combination of levels of i-FABP and venous lactate on the day of admission showed higher discriminative power in severe AP - AUC of 0.808. Conclusions Higher i-FABP levels on admission were associated with pancreatic necrosis, systemic complications, and severe AP. Low levels of i-FABP had a high negative predictive value for pancreatic necrosis and severe AP. Combination of levels of i-FABP and venous lactates on admission were superior to either of markers used alone in predicting severe AP.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
acute pancreatitis, i-FABP, intestinal permeability, prognosis
in
Pancreas
volume
47
issue
6
pages
6 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85049009708
ISSN
0885-3177
DOI
10.1097/MPA.0000000000001068
language
English
LU publication?
yes
id
671b4841-7b88-4042-8719-797e5613990b
date added to LUP
2018-07-04 12:50:59
date last changed
2019-03-08 02:47:17
@article{671b4841-7b88-4042-8719-797e5613990b,
  abstract     = {<p>Objectives The aim of this study was to study intestinal fatty acid binding protein (i-FABP) as a potential biomarker in predicting severity of acute pancreatitis (AP). Methods In a prospective multicenter cohort study, plasma levels of i-FABP were measured in 402 patients with AP. Severity of AP was determined based on the 1992 Atlanta Classification. Results Admission levels of plasma i-FABP were significantly higher in patients with pancreatic necrosis, in patients having systemic complications, in patients treated invasively, in patients treated in the intensive care unit, in patients with severe AP, and in deceased patients. Plasma i-FABP levels on admission yielded an area under curve (AUC) of 0.732 in discriminating patients with or without pancreatic necrosis and AUC of 0.669 in predicting severe AP. Combination of levels of i-FABP and venous lactate on the day of admission showed higher discriminative power in severe AP - AUC of 0.808. Conclusions Higher i-FABP levels on admission were associated with pancreatic necrosis, systemic complications, and severe AP. Low levels of i-FABP had a high negative predictive value for pancreatic necrosis and severe AP. Combination of levels of i-FABP and venous lactates on admission were superior to either of markers used alone in predicting severe AP.</p>},
  author       = {Kupčinskas, Juozas and Gedgaudas, Rolandas and Hartman, Hannes and Sippola, Tomi and Lindström, Outi and Johnson, Colin D. and Regnér, Sara},
  issn         = {0885-3177},
  keyword      = {acute pancreatitis,i-FABP,intestinal permeability,prognosis},
  language     = {eng},
  month        = {07},
  number       = {6},
  pages        = {715--720},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Pancreas},
  title        = {Intestinal fatty acid binding protein as a marker of necrosis and severity in acute pancreatitis},
  url          = {http://dx.doi.org/10.1097/MPA.0000000000001068},
  volume       = {47},
  year         = {2018},
}