Chaotic electrical activity of living beta-cells in the mouse pancreatic islet
(2007) In Physica D: Nonlinear Phenomena 226(2). p.107-116- Abstract
- To test for chaotic dynamics of the insulin producing beta-cell and explore its biological role, we observed the action potentials with the perforated patch clamp technique, for isolated cells as well as for intact cells of the mouse pancreatic islet. The time series obtained were analyzed using nonlinear diagnostic algorithms associated with the surrogate method. The isolated cells exhibited short-term predictability and visible determinism, in the steady state response to 10 mM glucose, while the intact cells did not. In the latter case, determinism became visible after the application of a gap junction inhibitor. This tendency was enhanced by the stimulation with tolbutamide. Our observations suggest that, thanks to the integration of... (More)
- To test for chaotic dynamics of the insulin producing beta-cell and explore its biological role, we observed the action potentials with the perforated patch clamp technique, for isolated cells as well as for intact cells of the mouse pancreatic islet. The time series obtained were analyzed using nonlinear diagnostic algorithms associated with the surrogate method. The isolated cells exhibited short-term predictability and visible determinism, in the steady state response to 10 mM glucose, while the intact cells did not. In the latter case, determinism became visible after the application of a gap junction inhibitor. This tendency was enhanced by the stimulation with tolbutamide. Our observations suggest that, thanks to the integration of individual chaotic dynamics via gap junction coupling, the beta-cells will lose memory of fluctuations occurring at any instant in their electrical activity more rapidly with time. This is likely to contribute to the functional stability of the islet against uncertain perturbations. (c) 2006 Elsevier B.V All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/672491
- author
- Kanno, Takahiro ; Miyano, Takaya ; Tokuda, Isao ; Galvanovskis, Juris LU and Wakui, Makoto
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- gap junction, pancreatic beta-cell, time series analysis, synchronization, chaos
- in
- Physica D: Nonlinear Phenomena
- volume
- 226
- issue
- 2
- pages
- 107 - 116
- publisher
- Elsevier
- external identifiers
-
- wos:000244572500001
- scopus:33846829684
- ISSN
- 0167-2789
- DOI
- 10.1016/j.physd.2006.11.007
- language
- English
- LU publication?
- yes
- id
- 40bbaea7-0564-4a6a-be40-f7ca5635d0b8 (old id 672491)
- date added to LUP
- 2016-04-01 15:47:03
- date last changed
- 2022-03-22 06:11:43
@article{40bbaea7-0564-4a6a-be40-f7ca5635d0b8,
abstract = {{To test for chaotic dynamics of the insulin producing beta-cell and explore its biological role, we observed the action potentials with the perforated patch clamp technique, for isolated cells as well as for intact cells of the mouse pancreatic islet. The time series obtained were analyzed using nonlinear diagnostic algorithms associated with the surrogate method. The isolated cells exhibited short-term predictability and visible determinism, in the steady state response to 10 mM glucose, while the intact cells did not. In the latter case, determinism became visible after the application of a gap junction inhibitor. This tendency was enhanced by the stimulation with tolbutamide. Our observations suggest that, thanks to the integration of individual chaotic dynamics via gap junction coupling, the beta-cells will lose memory of fluctuations occurring at any instant in their electrical activity more rapidly with time. This is likely to contribute to the functional stability of the islet against uncertain perturbations. (c) 2006 Elsevier B.V All rights reserved.}},
author = {{Kanno, Takahiro and Miyano, Takaya and Tokuda, Isao and Galvanovskis, Juris and Wakui, Makoto}},
issn = {{0167-2789}},
keywords = {{gap junction; pancreatic beta-cell; time series analysis; synchronization; chaos}},
language = {{eng}},
number = {{2}},
pages = {{107--116}},
publisher = {{Elsevier}},
series = {{Physica D: Nonlinear Phenomena}},
title = {{Chaotic electrical activity of living beta-cells in the mouse pancreatic islet}},
url = {{http://dx.doi.org/10.1016/j.physd.2006.11.007}},
doi = {{10.1016/j.physd.2006.11.007}},
volume = {{226}},
year = {{2007}},
}