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Chaotic electrical activity of living beta-cells in the mouse pancreatic islet

Kanno, Takahiro; Miyano, Takaya; Tokuda, Isao; Galvanovskis, Juris LU and Wakui, Makoto (2007) In Physica D: Nonlinear Phenomena 226(2). p.107-116
Abstract
To test for chaotic dynamics of the insulin producing beta-cell and explore its biological role, we observed the action potentials with the perforated patch clamp technique, for isolated cells as well as for intact cells of the mouse pancreatic islet. The time series obtained were analyzed using nonlinear diagnostic algorithms associated with the surrogate method. The isolated cells exhibited short-term predictability and visible determinism, in the steady state response to 10 mM glucose, while the intact cells did not. In the latter case, determinism became visible after the application of a gap junction inhibitor. This tendency was enhanced by the stimulation with tolbutamide. Our observations suggest that, thanks to the integration of... (More)
To test for chaotic dynamics of the insulin producing beta-cell and explore its biological role, we observed the action potentials with the perforated patch clamp technique, for isolated cells as well as for intact cells of the mouse pancreatic islet. The time series obtained were analyzed using nonlinear diagnostic algorithms associated with the surrogate method. The isolated cells exhibited short-term predictability and visible determinism, in the steady state response to 10 mM glucose, while the intact cells did not. In the latter case, determinism became visible after the application of a gap junction inhibitor. This tendency was enhanced by the stimulation with tolbutamide. Our observations suggest that, thanks to the integration of individual chaotic dynamics via gap junction coupling, the beta-cells will lose memory of fluctuations occurring at any instant in their electrical activity more rapidly with time. This is likely to contribute to the functional stability of the islet against uncertain perturbations. (c) 2006 Elsevier B.V All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
gap junction, pancreatic beta-cell, time series analysis, synchronization, chaos
in
Physica D: Nonlinear Phenomena
volume
226
issue
2
pages
107 - 116
publisher
Elsevier
external identifiers
  • wos:000244572500001
  • scopus:33846829684
ISSN
0167-2789
DOI
10.1016/j.physd.2006.11.007
language
English
LU publication?
yes
id
40bbaea7-0564-4a6a-be40-f7ca5635d0b8 (old id 672491)
date added to LUP
2007-12-13 10:02:32
date last changed
2017-05-28 04:18:02
@article{40bbaea7-0564-4a6a-be40-f7ca5635d0b8,
  abstract     = {To test for chaotic dynamics of the insulin producing beta-cell and explore its biological role, we observed the action potentials with the perforated patch clamp technique, for isolated cells as well as for intact cells of the mouse pancreatic islet. The time series obtained were analyzed using nonlinear diagnostic algorithms associated with the surrogate method. The isolated cells exhibited short-term predictability and visible determinism, in the steady state response to 10 mM glucose, while the intact cells did not. In the latter case, determinism became visible after the application of a gap junction inhibitor. This tendency was enhanced by the stimulation with tolbutamide. Our observations suggest that, thanks to the integration of individual chaotic dynamics via gap junction coupling, the beta-cells will lose memory of fluctuations occurring at any instant in their electrical activity more rapidly with time. This is likely to contribute to the functional stability of the islet against uncertain perturbations. (c) 2006 Elsevier B.V All rights reserved.},
  author       = {Kanno, Takahiro and Miyano, Takaya and Tokuda, Isao and Galvanovskis, Juris and Wakui, Makoto},
  issn         = {0167-2789},
  keyword      = {gap junction,pancreatic beta-cell,time series analysis,synchronization,chaos},
  language     = {eng},
  number       = {2},
  pages        = {107--116},
  publisher    = {Elsevier},
  series       = {Physica D: Nonlinear Phenomena},
  title        = {Chaotic electrical activity of living beta-cells in the mouse pancreatic islet},
  url          = {http://dx.doi.org/10.1016/j.physd.2006.11.007},
  volume       = {226},
  year         = {2007},
}