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Increased antibody levels to stage-specific Epstein–Barr virus antigens in systemic autoimmune diseases reveal a common pathology

Sternbaek, Louise; Draborg, Anette H.; Østerlund, Mark T.; Iversen, Line V.; Troelsen, Lone; Theander, Elke LU ; Nielsen, Christoffer T.; Jacobsen, Søren and Houen, Gunnar (2019) In Scandinavian Journal of Clinical and Laboratory Investigation
Abstract

The immune responses to antigens from different stages of the Epstein–Barr virus (EBV) life cycle were investigated in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren’s syndrome (SS), and systemic sclerosis (SSc) to gain knowledge of EBV’s involvement in the etiology of systemic autoimmune diseases (SADs) and for an overview of the humoral immune responses against EBV. Investigations were performed by the use of ELISA. IgM, IgA, and IgG antibody binding to 11 EBV antigens: EBNA1, EBNA2, BALF5, EAD, BALF2, EA/R, VCA p18, VCA p23, gB, gp350, and gp42 were examined in serum pools from SAD patients and healthy controls (HCs). Increased antibody levels against the 11 EBV antigens in the SAD pools were seen compared to... (More)

The immune responses to antigens from different stages of the Epstein–Barr virus (EBV) life cycle were investigated in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren’s syndrome (SS), and systemic sclerosis (SSc) to gain knowledge of EBV’s involvement in the etiology of systemic autoimmune diseases (SADs) and for an overview of the humoral immune responses against EBV. Investigations were performed by the use of ELISA. IgM, IgA, and IgG antibody binding to 11 EBV antigens: EBNA1, EBNA2, BALF5, EAD, BALF2, EA/R, VCA p18, VCA p23, gB, gp350, and gp42 were examined in serum pools from SAD patients and healthy controls (HCs). Increased antibody levels against the 11 EBV antigens in the SAD pools were seen compared to the HC pool. Specifically, SLE was characterized by strongly increased IgA to EAD both compared to HCs and other SADs, and RA was characterized by increased IgM levels to several EBV antigens. The SADs may be partly distinguished by their differential immune responses to various antigens in the EBV life cycle. All together, these findings support an association between EBV infection and SADs.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
antibodiess, Epstein–Barr virus, IgA, IgG, IgM, stage-specific antigens, systemic autoimmune diseases
in
Scandinavian Journal of Clinical and Laboratory Investigation
publisher
Informa Healthcare
external identifiers
  • scopus:85061337060
ISSN
0036-5513
DOI
10.1080/00365513.2018.1550807
language
English
LU publication?
yes
id
6755cbb6-0b43-4c0b-a353-9382b1234882
date added to LUP
2019-02-21 14:28:32
date last changed
2019-03-19 04:05:56
@article{6755cbb6-0b43-4c0b-a353-9382b1234882,
  abstract     = {<p>The immune responses to antigens from different stages of the Epstein–Barr virus (EBV) life cycle were investigated in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren’s syndrome (SS), and systemic sclerosis (SSc) to gain knowledge of EBV’s involvement in the etiology of systemic autoimmune diseases (SADs) and for an overview of the humoral immune responses against EBV. Investigations were performed by the use of ELISA. IgM, IgA, and IgG antibody binding to 11 EBV antigens: EBNA1, EBNA2, BALF5, EAD, BALF2, EA/R, VCA p18, VCA p23, gB, gp350, and gp42 were examined in serum pools from SAD patients and healthy controls (HCs). Increased antibody levels against the 11 EBV antigens in the SAD pools were seen compared to the HC pool. Specifically, SLE was characterized by strongly increased IgA to EAD both compared to HCs and other SADs, and RA was characterized by increased IgM levels to several EBV antigens. The SADs may be partly distinguished by their differential immune responses to various antigens in the EBV life cycle. All together, these findings support an association between EBV infection and SADs.</p>},
  author       = {Sternbaek, Louise and Draborg, Anette H. and Østerlund, Mark T. and Iversen, Line V. and Troelsen, Lone and Theander, Elke and Nielsen, Christoffer T. and Jacobsen, Søren and Houen, Gunnar},
  issn         = {0036-5513},
  keyword      = {antibodiess,Epstein–Barr virus,IgA,IgG,IgM,stage-specific antigens,systemic autoimmune diseases},
  language     = {eng},
  month        = {02},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Clinical and Laboratory Investigation},
  title        = {Increased antibody levels to stage-specific Epstein–Barr virus antigens in systemic autoimmune diseases reveal a common pathology},
  url          = {http://dx.doi.org/10.1080/00365513.2018.1550807},
  year         = {2019},
}