Mean muscle attenuation correlates with severe acute pancreatitis unlike visceral adipose tissue and subcutaneous adipose tissue
(2019) In United European Gastroenterology Journal 7(10). p.1312-1320- Abstract
Background: Acute pancreatitis (AP) is a frequent disorder with considerable morbidity and mortality. Obesity has previously been reported to influence disease severity. Objective: The aim of this study was to investigate the association of adipose and muscle parameters with the severity grade of AP. Methods: In total 454 patients were recruited. The first contrast-enhanced computed tomography of each patient was reviewed for adipose and muscle tissue parameters at L3 level. Associations with disease severity were analysed through logistic regression analysis. The predictive capacity of the parameters was investigated using receiver operating characteristic (ROC) curves. Results: No distinct variation was found between the AP severity... (More)
Background: Acute pancreatitis (AP) is a frequent disorder with considerable morbidity and mortality. Obesity has previously been reported to influence disease severity. Objective: The aim of this study was to investigate the association of adipose and muscle parameters with the severity grade of AP. Methods: In total 454 patients were recruited. The first contrast-enhanced computed tomography of each patient was reviewed for adipose and muscle tissue parameters at L3 level. Associations with disease severity were analysed through logistic regression analysis. The predictive capacity of the parameters was investigated using receiver operating characteristic (ROC) curves. Results: No distinct variation was found between the AP severity groups in either adipose tissue parameters (visceral adipose tissue and subcutaneous adipose tissue) or visceral muscle ratio. However, muscle mass and mean muscle attenuation differed significantly with p-values of 0.037 and 0.003 respectively. In multivariate analysis, low muscle attenuation was associated with severe AP with an odds ratio of 4.09 (95% confidence intervals: 1.61–10.36, p-value 0.003). No body parameter presented sufficient predictive capability in ROC-curve analysis. Conclusions: Our results demonstrate that a low muscle attenuation level is associated with an increased risk of severe AP. Future prospective studies will help identify the underlying mechanisms and characterise the influence of body composition parameters on AP.
(Less)
- author
- Sternby, Hanna
LU
; Mahle, Mariella
; Linder, Nicolas
; Erichson-Kirst, Laureen
; Verdonk, Robert C.
; Dimova, Alexandra
; Ignatavicius, Povilas
; Ilzarbe, Lucas
; Koiva, Peeter
; Penttilä, Anne
; Regnér, Sara
LU
; Bollen, Thomas L.
; Brill, Richard
; Stangl, Franz
; Wohlgemuth, Walter A.
; Singh, Vijay
; Busse, Harald
; Michl, Patrick
; Beer, Sebastian
and Rosendahl, Jonas
(Less) - organization
- publishing date
- 2019-10-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Acute pancreatitis, mean muscle attenuation, muscle mass, severity, visceral adipose tissue
- in
- United European Gastroenterology Journal
- volume
- 7
- issue
- 10
- pages
- 1312 - 1320
- publisher
- SAGE Publications
- external identifiers
-
- pmid:31839956
- scopus:85074115198
- ISSN
- 2050-6406
- DOI
- 10.1177/2050640619882520
- language
- English
- LU publication?
- yes
- id
- 676144fc-b991-4c60-9272-a9ccee389161
- date added to LUP
- 2019-11-07 13:48:23
- date last changed
- 2024-11-14 20:24:24
@article{676144fc-b991-4c60-9272-a9ccee389161,
abstract = {{<p>Background: Acute pancreatitis (AP) is a frequent disorder with considerable morbidity and mortality. Obesity has previously been reported to influence disease severity. Objective: The aim of this study was to investigate the association of adipose and muscle parameters with the severity grade of AP. Methods: In total 454 patients were recruited. The first contrast-enhanced computed tomography of each patient was reviewed for adipose and muscle tissue parameters at L3 level. Associations with disease severity were analysed through logistic regression analysis. The predictive capacity of the parameters was investigated using receiver operating characteristic (ROC) curves. Results: No distinct variation was found between the AP severity groups in either adipose tissue parameters (visceral adipose tissue and subcutaneous adipose tissue) or visceral muscle ratio. However, muscle mass and mean muscle attenuation differed significantly with p-values of 0.037 and 0.003 respectively. In multivariate analysis, low muscle attenuation was associated with severe AP with an odds ratio of 4.09 (95% confidence intervals: 1.61–10.36, p-value 0.003). No body parameter presented sufficient predictive capability in ROC-curve analysis. Conclusions: Our results demonstrate that a low muscle attenuation level is associated with an increased risk of severe AP. Future prospective studies will help identify the underlying mechanisms and characterise the influence of body composition parameters on AP.</p>}},
author = {{Sternby, Hanna and Mahle, Mariella and Linder, Nicolas and Erichson-Kirst, Laureen and Verdonk, Robert C. and Dimova, Alexandra and Ignatavicius, Povilas and Ilzarbe, Lucas and Koiva, Peeter and Penttilä, Anne and Regnér, Sara and Bollen, Thomas L. and Brill, Richard and Stangl, Franz and Wohlgemuth, Walter A. and Singh, Vijay and Busse, Harald and Michl, Patrick and Beer, Sebastian and Rosendahl, Jonas}},
issn = {{2050-6406}},
keywords = {{Acute pancreatitis; mean muscle attenuation; muscle mass; severity; visceral adipose tissue}},
language = {{eng}},
month = {{10}},
number = {{10}},
pages = {{1312--1320}},
publisher = {{SAGE Publications}},
series = {{United European Gastroenterology Journal}},
title = {{Mean muscle attenuation correlates with severe acute pancreatitis unlike visceral adipose tissue and subcutaneous adipose tissue}},
url = {{http://dx.doi.org/10.1177/2050640619882520}},
doi = {{10.1177/2050640619882520}},
volume = {{7}},
year = {{2019}},
}