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Coil-globule coexistence and compaction of DNA chains

Sarraguca, J. M. G. ; Dias, Rita LU and Pias, A. A. C. C. (2006) In Journal of Biological Physics 32(5). p.421-434
Abstract
In this work we discuss different factors governing coil-globule coexistence in the compaction process of DNA. We initially analyse the role played by fluctuations in the degree of binding of an external compacting agent in the conformational behavior of the chain backbone. The analysis relies both on Monte Carlo simulation results and simple statistical approaches. Compacting agents of various binding characteristics are taken into consideration and the degree of charge neutralization upon the chain is related to conformational indicators. Selected model systems comprising stiff chains in the presence of multivalent ions are employed to assess intrinsic single-chain conformational fluctuation, in the presence of external agents but not... (More)
In this work we discuss different factors governing coil-globule coexistence in the compaction process of DNA. We initially analyse the role played by fluctuations in the degree of binding of an external compacting agent in the conformational behavior of the chain backbone. The analysis relies both on Monte Carlo simulation results and simple statistical approaches. Compacting agents of various binding characteristics are taken into consideration and the degree of charge neutralization upon the chain is related to conformational indicators. Selected model systems comprising stiff chains in the presence of multivalent ions are employed to assess intrinsic single-chain conformational fluctuation, in the presence of external agents but not resulting from differences in binding. It is shown that trends found for a variety of compacting agents, including the extension of the coil-globule coexistence regions, can be ratio-nalised on the basis of this analysis. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
DNA, compaction, coil-globule coexistence, condensation
in
Journal of Biological Physics
volume
32
issue
5
pages
421 - 434
publisher
Kluwer
external identifiers
  • wos:000243819900006
  • scopus:33846616273
ISSN
0092-0606
DOI
10.1007/s10867-006-9026-8
language
English
LU publication?
yes
id
cd0896ed-4b13-48bd-83f2-9523425ae32d (old id 676188)
date added to LUP
2016-04-01 15:24:42
date last changed
2021-02-17 07:59:59
@article{cd0896ed-4b13-48bd-83f2-9523425ae32d,
  abstract     = {In this work we discuss different factors governing coil-globule coexistence in the compaction process of DNA. We initially analyse the role played by fluctuations in the degree of binding of an external compacting agent in the conformational behavior of the chain backbone. The analysis relies both on Monte Carlo simulation results and simple statistical approaches. Compacting agents of various binding characteristics are taken into consideration and the degree of charge neutralization upon the chain is related to conformational indicators. Selected model systems comprising stiff chains in the presence of multivalent ions are employed to assess intrinsic single-chain conformational fluctuation, in the presence of external agents but not resulting from differences in binding. It is shown that trends found for a variety of compacting agents, including the extension of the coil-globule coexistence regions, can be ratio-nalised on the basis of this analysis.},
  author       = {Sarraguca, J. M. G. and Dias, Rita and Pias, A. A. C. C.},
  issn         = {0092-0606},
  language     = {eng},
  number       = {5},
  pages        = {421--434},
  publisher    = {Kluwer},
  series       = {Journal of Biological Physics},
  title        = {Coil-globule coexistence and compaction of DNA chains},
  url          = {http://dx.doi.org/10.1007/s10867-006-9026-8},
  doi          = {10.1007/s10867-006-9026-8},
  volume       = {32},
  year         = {2006},
}