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Effects of testosterone and corticosterone on immunocompetence in the zebra finch

Roberts, Mark L.; Buchanan, Katherine L.; Hasselquist, Dennis LU and Evans, Matthew R. (2007) In Hormones and Behavior 51(1). p.126-134
Abstract
The original immunocompetence handicap hypothesis (ICHH) suggested that testosterone has a handicapping effect in males by both promoting the development of sexual signals and suppressing immune function. A modified version, the stress-linked ICHH, has recently proposed that testosterone is immunosuppressive indirectly by increasing production of corticosterone. To test both the original and stress-mediated versions of the ICHH, we implanted male zebra finches taken from lines selected for divergent maximum stress-induced levels of corticosterone (high, low and control) with either empty or testosterone-filled implants. Their Immoral and cell-mediated immune responses were then assessed by challenge with diphtheria:tetanus vaccine and... (More)
The original immunocompetence handicap hypothesis (ICHH) suggested that testosterone has a handicapping effect in males by both promoting the development of sexual signals and suppressing immune function. A modified version, the stress-linked ICHH, has recently proposed that testosterone is immunosuppressive indirectly by increasing production of corticosterone. To test both the original and stress-mediated versions of the ICHH, we implanted male zebra finches taken from lines selected for divergent maximum stress-induced levels of corticosterone (high, low and control) with either empty or testosterone-filled implants. Their Immoral and cell-mediated immune responses were then assessed by challenge with diphtheria:tetanus vaccine and phytohemagglutinin respectively. We found no effect of the hormone manipulations on either PHA or tetanus antibody responses, but found a significant interaction between titers of both testosterone and corticosterone on diphtheria secondary antibody response; antibody response was greatest in individuals with high levels of both hormones. There was also a significant interactive effect between testosterone treatment group and corticosterone titer on body mass; the body mass of males in the elevated testosterone treatment group decreased with increasing corticosterone titer. These results suggest that, contrary to the assumption of the stress-mediated version of the ICHH, high plasma levels of corticosterone are not immunosuppressive, but are in fact immuno-enhancing in the presence of high levels of plasma testosterone. Equally, the central assumption of the ICHH that testosterone is obligately immunosuppressive is also not supported. The same individuals with the highest levels of both hormones and consequently the most robust antibody response also possessed the lowest body mass. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
immunocompetence handicap hypothesis, immunocompetence, zebra finch, glucocorticoid, corticosterone, testosterone, PHA, diphtheria : tetanus, stress
in
Hormones and Behavior
volume
51
issue
1
pages
126 - 134
publisher
Elsevier
external identifiers
  • wos:000243645100016
  • scopus:33751546194
ISSN
1095-6867
DOI
10.1016/j.yhbeh.2006.09.004
language
English
LU publication?
yes
id
6e433575-8453-4415-8b57-856fe05b1dde (old id 676643)
date added to LUP
2007-12-14 12:12:06
date last changed
2017-11-12 03:22:30
@article{6e433575-8453-4415-8b57-856fe05b1dde,
  abstract     = {The original immunocompetence handicap hypothesis (ICHH) suggested that testosterone has a handicapping effect in males by both promoting the development of sexual signals and suppressing immune function. A modified version, the stress-linked ICHH, has recently proposed that testosterone is immunosuppressive indirectly by increasing production of corticosterone. To test both the original and stress-mediated versions of the ICHH, we implanted male zebra finches taken from lines selected for divergent maximum stress-induced levels of corticosterone (high, low and control) with either empty or testosterone-filled implants. Their Immoral and cell-mediated immune responses were then assessed by challenge with diphtheria:tetanus vaccine and phytohemagglutinin respectively. We found no effect of the hormone manipulations on either PHA or tetanus antibody responses, but found a significant interaction between titers of both testosterone and corticosterone on diphtheria secondary antibody response; antibody response was greatest in individuals with high levels of both hormones. There was also a significant interactive effect between testosterone treatment group and corticosterone titer on body mass; the body mass of males in the elevated testosterone treatment group decreased with increasing corticosterone titer. These results suggest that, contrary to the assumption of the stress-mediated version of the ICHH, high plasma levels of corticosterone are not immunosuppressive, but are in fact immuno-enhancing in the presence of high levels of plasma testosterone. Equally, the central assumption of the ICHH that testosterone is obligately immunosuppressive is also not supported. The same individuals with the highest levels of both hormones and consequently the most robust antibody response also possessed the lowest body mass.},
  author       = {Roberts, Mark L. and Buchanan, Katherine L. and Hasselquist, Dennis and Evans, Matthew R.},
  issn         = {1095-6867},
  keyword      = {immunocompetence handicap hypothesis,immunocompetence,zebra finch,glucocorticoid,corticosterone,testosterone,PHA,diphtheria : tetanus,stress},
  language     = {eng},
  number       = {1},
  pages        = {126--134},
  publisher    = {Elsevier},
  series       = {Hormones and Behavior},
  title        = {Effects of testosterone and corticosterone on immunocompetence in the zebra finch},
  url          = {http://dx.doi.org/10.1016/j.yhbeh.2006.09.004},
  volume       = {51},
  year         = {2007},
}