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Quantile-specific confounding : correction for subtle population stratification via quantile regression

Wang, Chen ; Masala, Marco ; Fiorillo, Edoardo ; Devoto, Marcella ; Cucca, Francesco and Ionita-Laza, Iuliana LU (2025) In Genetics 231(1).
Abstract

Subtle population structure remains a significant concern in genome-wide association studies. Using human height as an example, we show how quantile regression, a natural extension of linear regression, can better correct for subtle population structure due to its inherent ability to adjust for quantile-specific effects of covariates such as principal components. We utilize data from the UK Biobank and the SardiNIA/ProgeNIA project for demonstration.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
GWAS, population stratification, quantile regression, quantile specific confounding
in
Genetics
volume
231
issue
1
article number
iyaf138
publisher
Oxford University Press
external identifiers
  • scopus:105015553149
  • pmid:40690556
ISSN
0016-6731
DOI
10.1093/genetics/iyaf138
language
English
LU publication?
yes
id
67674d4c-4416-4496-a312-7e17dcb31a8e
date added to LUP
2025-10-15 15:44:37
date last changed
2025-12-10 20:30:17
@article{67674d4c-4416-4496-a312-7e17dcb31a8e,
  abstract     = {{<p>Subtle population structure remains a significant concern in genome-wide association studies. Using human height as an example, we show how quantile regression, a natural extension of linear regression, can better correct for subtle population structure due to its inherent ability to adjust for quantile-specific effects of covariates such as principal components. We utilize data from the UK Biobank and the SardiNIA/ProgeNIA project for demonstration.</p>}},
  author       = {{Wang, Chen and Masala, Marco and Fiorillo, Edoardo and Devoto, Marcella and Cucca, Francesco and Ionita-Laza, Iuliana}},
  issn         = {{0016-6731}},
  keywords     = {{GWAS; population stratification; quantile regression; quantile specific confounding}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Oxford University Press}},
  series       = {{Genetics}},
  title        = {{Quantile-specific confounding : correction for subtle population stratification via quantile regression}},
  url          = {{http://dx.doi.org/10.1093/genetics/iyaf138}},
  doi          = {{10.1093/genetics/iyaf138}},
  volume       = {{231}},
  year         = {{2025}},
}