Advanced

Ethanol prevents development of destructive arthritis

Jonsson, Ing-Marie; Verdrengh, Margareta; Brisslert, Mikael; Lindblad, Sofia; Bokarewa, Maria; Islander, Ulrika; Carlsten, Hans; Ohlsson, Claes; Nandakumar, Kutty Selva and Holmdahl, Rikard LU , et al. (2007) In Proceedings of the National Academy of Sciences 104(1). p.258-263
Abstract
Environmental factors are thought to play a major role in the development of rheumatoid arthritis. Because the use of ethanol is widespread, we assessed the role of ethanol intake on the propensity to develop chronic arthritis. Collagen type II-immunized mice were given water or water containing 10% (vol/vol) ethanol or its metabolite acetaldehyde. Their development of arthritis was assessed, as well as the impact of ethanol on leukocyte migration and activation of intracellular transcription factors. Mice exposed daily to this dose of ethanol did not display any liver toxicity, and the development of erosive arthritis was almost totally abrogated. In contrast, the anti body-mediated effector phase of collagen-induced arthritis was not... (More)
Environmental factors are thought to play a major role in the development of rheumatoid arthritis. Because the use of ethanol is widespread, we assessed the role of ethanol intake on the propensity to develop chronic arthritis. Collagen type II-immunized mice were given water or water containing 10% (vol/vol) ethanol or its metabolite acetaldehyde. Their development of arthritis was assessed, as well as the impact of ethanol on leukocyte migration and activation of intracellular transcription factors. Mice exposed daily to this dose of ethanol did not display any liver toxicity, and the development of erosive arthritis was almost totally abrogated. In contrast, the anti body-mediated effector phase of collagen-induced arthritis was not influenced by ethanol exposure. Also, the major ethanol metabolite, acetaldehyde, prevented the development of arthritis. This antiinflammatory and antidestructive property of ethanol was mediated by (i) down-regulation of leukocyte migration and (ii) up-regulation of testosterone secretion, with the latter leading to decreased NF-kappa B activation. We conclude that low but persistent ethanol consumption delays the onset and halts the progression of collagen-induced arthritis by interaction with innate immune responsiveness. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
antibodies, sex hormones, inflammation, cytokines, immunity
in
Proceedings of the National Academy of Sciences
volume
104
issue
1
pages
258 - 263
publisher
National Acad Sciences
external identifiers
  • wos:000243456300048
  • scopus:33846033048
ISSN
1091-6490
DOI
10.1073/pnas.0608620104
language
English
LU publication?
yes
id
5b346128-a94a-4bb5-a03f-f4341e7636b4 (old id 676833)
date added to LUP
2007-12-12 08:54:54
date last changed
2017-11-12 03:31:03
@article{5b346128-a94a-4bb5-a03f-f4341e7636b4,
  abstract     = {Environmental factors are thought to play a major role in the development of rheumatoid arthritis. Because the use of ethanol is widespread, we assessed the role of ethanol intake on the propensity to develop chronic arthritis. Collagen type II-immunized mice were given water or water containing 10% (vol/vol) ethanol or its metabolite acetaldehyde. Their development of arthritis was assessed, as well as the impact of ethanol on leukocyte migration and activation of intracellular transcription factors. Mice exposed daily to this dose of ethanol did not display any liver toxicity, and the development of erosive arthritis was almost totally abrogated. In contrast, the anti body-mediated effector phase of collagen-induced arthritis was not influenced by ethanol exposure. Also, the major ethanol metabolite, acetaldehyde, prevented the development of arthritis. This antiinflammatory and antidestructive property of ethanol was mediated by (i) down-regulation of leukocyte migration and (ii) up-regulation of testosterone secretion, with the latter leading to decreased NF-kappa B activation. We conclude that low but persistent ethanol consumption delays the onset and halts the progression of collagen-induced arthritis by interaction with innate immune responsiveness.},
  author       = {Jonsson, Ing-Marie and Verdrengh, Margareta and Brisslert, Mikael and Lindblad, Sofia and Bokarewa, Maria and Islander, Ulrika and Carlsten, Hans and Ohlsson, Claes and Nandakumar, Kutty Selva and Holmdahl, Rikard and Tarkowski, Andrej},
  issn         = {1091-6490},
  keyword      = {antibodies,sex hormones,inflammation,cytokines,immunity},
  language     = {eng},
  number       = {1},
  pages        = {258--263},
  publisher    = {National Acad Sciences},
  series       = {Proceedings of the National Academy of Sciences},
  title        = {Ethanol prevents development of destructive arthritis},
  url          = {http://dx.doi.org/10.1073/pnas.0608620104},
  volume       = {104},
  year         = {2007},
}