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Introducing a new tool for the assessment of progressive keratoconus: the Scandinavian Keratoconus Progression Application

Gustafsson, Ingemar LU ; Neumann, Olof LU ; Bizios, Dimitrios LU orcid ; Ivarsen, Anders and Hjortdal, Jesper (2022) In Journal of EuCornea 11(3). p.1-9
Abstract
Purpose
To develop an application for the Pentacam HR for the purpose of optimising the accuracy of the diagnosis of progressive keratoconus.
Methods
Measurements were performed on one randomised eye in twenty-five subjects with keratoconus Stage 1-2 according to the Amsler-Krumeich classification on two occasions, three days apart. Four replicate measurements were made by a single examiner on each occasion. The inter-day repeatability and detection limits for the diagnosis of progressive keratoconus were calculated for the following parameters: K2 and Kmax, and the parameters A, B and C from the Belin ABCD Progression Display. The measurements used as input are automatically extracted from the Pentacam HR database as... (More)
Purpose
To develop an application for the Pentacam HR for the purpose of optimising the accuracy of the diagnosis of progressive keratoconus.
Methods
Measurements were performed on one randomised eye in twenty-five subjects with keratoconus Stage 1-2 according to the Amsler-Krumeich classification on two occasions, three days apart. Four replicate measurements were made by a single examiner on each occasion. The inter-day repeatability and detection limits for the diagnosis of progressive keratoconus were calculated for the following parameters: K2 and Kmax, and the parameters A, B and C from the Belin ABCD Progression Display. The measurements used as input are automatically extracted from the Pentacam HR database as comma-separated values. The application, developed in the R programming environment, provides a web browser-based user interface that presents these parameters both numerically and graphically.
Results
The application includes detection limits for the diagnosis of progressive keratoconus obtained from two previous studies on the inter-day repeatability of measurements in subjects with keratoconus. The detection limits are based on inter-day repeatability, stratified according to disease severity, allowing the comparison of single measurements or a mean of four replicates.
Conclusions
This is the first application to provide an assessment of progressive keratoconus using detection limits based on inter-day repeatability. We believe this application will contribute to the more accurate diagnosis of progressive keratoconus. It also facilitates diagnosis and improves the clinical workflow as all the relevant information is presented numerically, graphically, and colour-coded in one interface. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of EuCornea
volume
11
issue
3
pages
1 - 9
ISSN
2452-4034
DOI
10.57073/001c.68427
language
English
LU publication?
yes
id
676b2e35-56c3-4b67-b763-ea497fc53346
date added to LUP
2023-08-17 11:12:13
date last changed
2023-08-22 11:26:18
@article{676b2e35-56c3-4b67-b763-ea497fc53346,
  abstract     = {{Purpose<br/>To develop an application for the Pentacam HR for the purpose of optimising the accuracy of the diagnosis of progressive keratoconus.<br/>Methods<br/>Measurements were performed on one randomised eye in twenty-five subjects with keratoconus Stage 1-2 according to the Amsler-Krumeich classification on two occasions, three days apart. Four replicate measurements were made by a single examiner on each occasion. The inter-day repeatability and detection limits for the diagnosis of progressive keratoconus were calculated for the following parameters: K2 and Kmax, and the parameters A, B and C from the Belin ABCD Progression Display. The measurements used as input are automatically extracted from the Pentacam HR database as comma-separated values. The application, developed in the R programming environment, provides a web browser-based user interface that presents these parameters both numerically and graphically.<br/>Results<br/>The application includes detection limits for the diagnosis of progressive keratoconus obtained from two previous studies on the inter-day repeatability of measurements in subjects with keratoconus. The detection limits are based on inter-day repeatability, stratified according to disease severity, allowing the comparison of single measurements or a mean of four replicates.<br/>Conclusions<br/>This is the first application to provide an assessment of progressive keratoconus using detection limits based on inter-day repeatability. We believe this application will contribute to the more accurate diagnosis of progressive keratoconus. It also facilitates diagnosis and improves the clinical workflow as all the relevant information is presented numerically, graphically, and colour-coded in one interface.}},
  author       = {{Gustafsson, Ingemar and Neumann, Olof and Bizios, Dimitrios and Ivarsen, Anders and Hjortdal, Jesper}},
  issn         = {{2452-4034}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{1--9}},
  series       = {{Journal of EuCornea}},
  title        = {{Introducing a new tool for the assessment of progressive keratoconus: the Scandinavian Keratoconus Progression Application}},
  url          = {{http://dx.doi.org/10.57073/001c.68427}},
  doi          = {{10.57073/001c.68427}},
  volume       = {{11}},
  year         = {{2022}},
}