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Clinical course of nonvisceral soft tissue leiomyosarcoma in 225 patients from the Scandinavian Sarcoma Group

Svarvar, Catarina; Bohling, Tom; Berlin, Orjan; Gustafson, Pelle LU ; Folleras, Gunnar; Bjerkehagen, Bodil; Domanski, Henryk LU ; Hall, Kirsten Sundby; Tukiainen, Erkki and Blomqvist, Carl (2007) In Cancer 109(2). p.282-291
Abstract
BACKGROUND. Leiomyosarcoma of nonvisceral soft tissues is an uncommon malignant tumor; thus, only small numbers of cases have been reported. This study was based on a large series of patients from the Scandinavian Sarcoma Group Register acquired during a 15-year period (from 1986 to 2001). Follow-up information was available for all patients. METHODS. The authors analyzed the clinical features of 225 patients with cutaneous, subcutaneous, or deep-seated leiomyosarcoma of the extremities, trunk wall, and superficial parts of the head and neck region to determine the natural course of the disease. Only patients who received their treatment at a specialist sarcoma center were included. Re-evaluation of histopathology was performed. RESULTS.... (More)
BACKGROUND. Leiomyosarcoma of nonvisceral soft tissues is an uncommon malignant tumor; thus, only small numbers of cases have been reported. This study was based on a large series of patients from the Scandinavian Sarcoma Group Register acquired during a 15-year period (from 1986 to 2001). Follow-up information was available for all patients. METHODS. The authors analyzed the clinical features of 225 patients with cutaneous, subcutaneous, or deep-seated leiomyosarcoma of the extremities, trunk wall, and superficial parts of the head and neck region to determine the natural course of the disease. Only patients who received their treatment at a specialist sarcoma center were included. Re-evaluation of histopathology was performed. RESULTS. The age of the patients (121 women and 104 men) ranged from 20 years to 98 years (median, 70 years), and the tumors ranged in size from 0.6 cm to 35 cm (median, 4.0 cm). Eighty-two percent of the tumors were classified as high grade. The median follow-up for survivors was 5.5 years. The local treatment was adequate in 154 of 206 patients (75%) who were without metastasis at presentation. At 10 years, 84% of the 206 patients with localized disease at presentation were free from local recurrence, 66% remained metastasis free, and 49% were alive. Multivariate analysis showed that higher malignancy grade (P =.006), larger tumor size (P =.003), and deeper tumor location (P =.002) were correlated significantly with decreased metastasis-free survival, inadequate local treatment was correlated with local recurrence (P =.007), and high malignancy grade was correlated with decreased overall survival (P =.007). CONCLUSIONS. The long-term prognosis for patients with subcutaneous and deep-seated soft tissue leiomyosarcoma remains poor despite the ability to achieve adequate local control through nonmutilating surgery with or without radiotherapy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
prognosis, leiomyosarcoma, metastasis, soft tissue sacrorna
in
Cancer
volume
109
issue
2
pages
282 - 291
publisher
John Wiley & Sons
external identifiers
  • wos:000243549500015
  • scopus:33846188488
ISSN
1097-0142
DOI
10.1002/cncr.22395
language
English
LU publication?
yes
id
55e5ec95-c86e-49be-9574-02a66b461ceb (old id 677523)
date added to LUP
2007-12-18 15:20:56
date last changed
2017-10-01 03:57:54
@article{55e5ec95-c86e-49be-9574-02a66b461ceb,
  abstract     = {BACKGROUND. Leiomyosarcoma of nonvisceral soft tissues is an uncommon malignant tumor; thus, only small numbers of cases have been reported. This study was based on a large series of patients from the Scandinavian Sarcoma Group Register acquired during a 15-year period (from 1986 to 2001). Follow-up information was available for all patients. METHODS. The authors analyzed the clinical features of 225 patients with cutaneous, subcutaneous, or deep-seated leiomyosarcoma of the extremities, trunk wall, and superficial parts of the head and neck region to determine the natural course of the disease. Only patients who received their treatment at a specialist sarcoma center were included. Re-evaluation of histopathology was performed. RESULTS. The age of the patients (121 women and 104 men) ranged from 20 years to 98 years (median, 70 years), and the tumors ranged in size from 0.6 cm to 35 cm (median, 4.0 cm). Eighty-two percent of the tumors were classified as high grade. The median follow-up for survivors was 5.5 years. The local treatment was adequate in 154 of 206 patients (75%) who were without metastasis at presentation. At 10 years, 84% of the 206 patients with localized disease at presentation were free from local recurrence, 66% remained metastasis free, and 49% were alive. Multivariate analysis showed that higher malignancy grade (P =.006), larger tumor size (P =.003), and deeper tumor location (P =.002) were correlated significantly with decreased metastasis-free survival, inadequate local treatment was correlated with local recurrence (P =.007), and high malignancy grade was correlated with decreased overall survival (P =.007). CONCLUSIONS. The long-term prognosis for patients with subcutaneous and deep-seated soft tissue leiomyosarcoma remains poor despite the ability to achieve adequate local control through nonmutilating surgery with or without radiotherapy.},
  author       = {Svarvar, Catarina and Bohling, Tom and Berlin, Orjan and Gustafson, Pelle and Folleras, Gunnar and Bjerkehagen, Bodil and Domanski, Henryk and Hall, Kirsten Sundby and Tukiainen, Erkki and Blomqvist, Carl},
  issn         = {1097-0142},
  keyword      = {prognosis,leiomyosarcoma,metastasis,soft tissue sacrorna},
  language     = {eng},
  number       = {2},
  pages        = {282--291},
  publisher    = {John Wiley & Sons},
  series       = {Cancer},
  title        = {Clinical course of nonvisceral soft tissue leiomyosarcoma in 225 patients from the Scandinavian Sarcoma Group},
  url          = {http://dx.doi.org/10.1002/cncr.22395},
  volume       = {109},
  year         = {2007},
}