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Five-year follow-up of new cases after a coeliac disease mass screening

Sandström, Olof ; Norström, Fredrik ; Carlsson, Annelie LU orcid ; Högberg, Lotta ; van der Palz, Maria ; Stenhammar, Lars ; Webb, Charlotta LU ; Ivarsson, Anneli and Myléus, Anna (2022) In Archives of Disease in Childhood 107(6). p.596-600
Abstract

OBJECTIVE: We previously performed a population-based mass screening of coeliac disease in children aged 12 years in two birth cohorts resulting in 296 seropositive children, of whom 242 were diagnosed with coeliac disease after duodenal biopsies. In this follow-up study, we wanted to identify new cases in the screening population that tested negative-either converting from potential coeliac disease (seropositive but normal duodenal mucosa) or converting from seronegative at screening to diagnosed coeliac disease. METHODS: All seropositive children were invited to a follow-up appointment 5 years after the screening with renewed serological testing and recommended endoscopic investigation if seropositive. Seronegative children in the... (More)

OBJECTIVE: We previously performed a population-based mass screening of coeliac disease in children aged 12 years in two birth cohorts resulting in 296 seropositive children, of whom 242 were diagnosed with coeliac disease after duodenal biopsies. In this follow-up study, we wanted to identify new cases in the screening population that tested negative-either converting from potential coeliac disease (seropositive but normal duodenal mucosa) or converting from seronegative at screening to diagnosed coeliac disease. METHODS: All seropositive children were invited to a follow-up appointment 5 years after the screening with renewed serological testing and recommended endoscopic investigation if seropositive. Seronegative children in the screening study (n=12 353) were linked to the National Swedish Childhood Coeliac Disease Register to find cases diagnosed in healthcare during the same period. RESULTS: In total, 230 (77%) came to the follow-up appointment, including 34 of 39 with potential coeliac disease. Of these, 11 (32%) had converted to coeliac disease. One new case was found in the National Swedish Childhood Coeliac Disease Register who received the diagnosis through routine screening in children with type 1 diabetes. CONCLUSIONS: There is a high risk of conversion to coeliac disease among those with potential disease. However, a negative screening test was associated with a very low risk for a clinical diagnosis within a follow-up period of 5 years.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
epidemiology, gastroenterology, paediatrics
in
Archives of Disease in Childhood
volume
107
issue
6
pages
5 pages
publisher
BMJ Publishing Group
external identifiers
  • scopus:85130767943
  • pmid:34921003
ISSN
0003-9888
DOI
10.1136/archdischild-2021-322755
language
English
LU publication?
yes
additional info
Publisher Copyright: © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
id
677c072c-075a-42fc-9899-956274ed182b
date added to LUP
2022-12-30 13:00:21
date last changed
2024-06-10 05:42:17
@article{677c072c-075a-42fc-9899-956274ed182b,
  abstract     = {{<p>OBJECTIVE: We previously performed a population-based mass screening of coeliac disease in children aged 12 years in two birth cohorts resulting in 296 seropositive children, of whom 242 were diagnosed with coeliac disease after duodenal biopsies. In this follow-up study, we wanted to identify new cases in the screening population that tested negative-either converting from potential coeliac disease (seropositive but normal duodenal mucosa) or converting from seronegative at screening to diagnosed coeliac disease. METHODS: All seropositive children were invited to a follow-up appointment 5 years after the screening with renewed serological testing and recommended endoscopic investigation if seropositive. Seronegative children in the screening study (n=12 353) were linked to the National Swedish Childhood Coeliac Disease Register to find cases diagnosed in healthcare during the same period. RESULTS: In total, 230 (77%) came to the follow-up appointment, including 34 of 39 with potential coeliac disease. Of these, 11 (32%) had converted to coeliac disease. One new case was found in the National Swedish Childhood Coeliac Disease Register who received the diagnosis through routine screening in children with type 1 diabetes. CONCLUSIONS: There is a high risk of conversion to coeliac disease among those with potential disease. However, a negative screening test was associated with a very low risk for a clinical diagnosis within a follow-up period of 5 years.</p>}},
  author       = {{Sandström, Olof and Norström, Fredrik and Carlsson, Annelie and Högberg, Lotta and van der Palz, Maria and Stenhammar, Lars and Webb, Charlotta and Ivarsson, Anneli and Myléus, Anna}},
  issn         = {{0003-9888}},
  keywords     = {{epidemiology; gastroenterology; paediatrics}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{6}},
  pages        = {{596--600}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{Archives of Disease in Childhood}},
  title        = {{Five-year follow-up of new cases after a coeliac disease mass screening}},
  url          = {{http://dx.doi.org/10.1136/archdischild-2021-322755}},
  doi          = {{10.1136/archdischild-2021-322755}},
  volume       = {{107}},
  year         = {{2022}},
}