Five-year follow-up of new cases after a coeliac disease mass screening
(2022) In Archives of Disease in Childhood 107(6). p.596-600- Abstract
OBJECTIVE: We previously performed a population-based mass screening of coeliac disease in children aged 12 years in two birth cohorts resulting in 296 seropositive children, of whom 242 were diagnosed with coeliac disease after duodenal biopsies. In this follow-up study, we wanted to identify new cases in the screening population that tested negative-either converting from potential coeliac disease (seropositive but normal duodenal mucosa) or converting from seronegative at screening to diagnosed coeliac disease. METHODS: All seropositive children were invited to a follow-up appointment 5 years after the screening with renewed serological testing and recommended endoscopic investigation if seropositive. Seronegative children in the... (More)
OBJECTIVE: We previously performed a population-based mass screening of coeliac disease in children aged 12 years in two birth cohorts resulting in 296 seropositive children, of whom 242 were diagnosed with coeliac disease after duodenal biopsies. In this follow-up study, we wanted to identify new cases in the screening population that tested negative-either converting from potential coeliac disease (seropositive but normal duodenal mucosa) or converting from seronegative at screening to diagnosed coeliac disease. METHODS: All seropositive children were invited to a follow-up appointment 5 years after the screening with renewed serological testing and recommended endoscopic investigation if seropositive. Seronegative children in the screening study (n=12 353) were linked to the National Swedish Childhood Coeliac Disease Register to find cases diagnosed in healthcare during the same period. RESULTS: In total, 230 (77%) came to the follow-up appointment, including 34 of 39 with potential coeliac disease. Of these, 11 (32%) had converted to coeliac disease. One new case was found in the National Swedish Childhood Coeliac Disease Register who received the diagnosis through routine screening in children with type 1 diabetes. CONCLUSIONS: There is a high risk of conversion to coeliac disease among those with potential disease. However, a negative screening test was associated with a very low risk for a clinical diagnosis within a follow-up period of 5 years.
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- author
- Sandström, Olof ; Norström, Fredrik ; Carlsson, Annelie LU ; Högberg, Lotta ; van der Palz, Maria ; Stenhammar, Lars ; Webb, Charlotta LU ; Ivarsson, Anneli and Myléus, Anna
- organization
- publishing date
- 2022-06-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- epidemiology, gastroenterology, paediatrics
- in
- Archives of Disease in Childhood
- volume
- 107
- issue
- 6
- pages
- 5 pages
- publisher
- BMJ Publishing Group
- external identifiers
-
- pmid:34921003
- scopus:85130767943
- ISSN
- 0003-9888
- DOI
- 10.1136/archdischild-2021-322755
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
- id
- 677c072c-075a-42fc-9899-956274ed182b
- date added to LUP
- 2022-12-30 13:00:21
- date last changed
- 2024-09-16 14:51:42
@article{677c072c-075a-42fc-9899-956274ed182b, abstract = {{<p>OBJECTIVE: We previously performed a population-based mass screening of coeliac disease in children aged 12 years in two birth cohorts resulting in 296 seropositive children, of whom 242 were diagnosed with coeliac disease after duodenal biopsies. In this follow-up study, we wanted to identify new cases in the screening population that tested negative-either converting from potential coeliac disease (seropositive but normal duodenal mucosa) or converting from seronegative at screening to diagnosed coeliac disease. METHODS: All seropositive children were invited to a follow-up appointment 5 years after the screening with renewed serological testing and recommended endoscopic investigation if seropositive. Seronegative children in the screening study (n=12 353) were linked to the National Swedish Childhood Coeliac Disease Register to find cases diagnosed in healthcare during the same period. RESULTS: In total, 230 (77%) came to the follow-up appointment, including 34 of 39 with potential coeliac disease. Of these, 11 (32%) had converted to coeliac disease. One new case was found in the National Swedish Childhood Coeliac Disease Register who received the diagnosis through routine screening in children with type 1 diabetes. CONCLUSIONS: There is a high risk of conversion to coeliac disease among those with potential disease. However, a negative screening test was associated with a very low risk for a clinical diagnosis within a follow-up period of 5 years.</p>}}, author = {{Sandström, Olof and Norström, Fredrik and Carlsson, Annelie and Högberg, Lotta and van der Palz, Maria and Stenhammar, Lars and Webb, Charlotta and Ivarsson, Anneli and Myléus, Anna}}, issn = {{0003-9888}}, keywords = {{epidemiology; gastroenterology; paediatrics}}, language = {{eng}}, month = {{06}}, number = {{6}}, pages = {{596--600}}, publisher = {{BMJ Publishing Group}}, series = {{Archives of Disease in Childhood}}, title = {{Five-year follow-up of new cases after a coeliac disease mass screening}}, url = {{http://dx.doi.org/10.1136/archdischild-2021-322755}}, doi = {{10.1136/archdischild-2021-322755}}, volume = {{107}}, year = {{2022}}, }