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Role of Helicobacter pylori in conjunctival mucosa-associated lymphoid tissue lymphoma

Sjo, Nicolai C.; Foegh, Pia; Juhl, Birgitte R.; Nilsson, Hans-Olof LU ; Prause, Jan U.; Ralfkiaer, Elisabeth; Wadström, Torkel LU and Heegaard, Steffen (2007) In Ophthalmology 114(1). p.182-186
Abstract
Objective: Conjunctiva-associated lymphoid tissue is the conjunctival equivalent to mucosa-associated lymphoid tissue (MALT). Mucosa-associated lymphoid tissue lymphoma has been shown to be associated with Helicobacter pylori. In this study, the prevalence and possible role of H. pylori infection in conjunctival MALT lymphoma were evaluated. Design: Retrospective noncomparative case series. Participants: Thirteen cases of conjunctival MALT lymphoma were investigated. Five samples of conjunctival lymphoid hyperplasia and 20 biopsies of normal conjunctiva served as controls. Methods: The specimens were investigated for the presence of H. pylori with immunohistochemistry (IHC) and nested polymerase chain reaction (PCR) techniques. For each... (More)
Objective: Conjunctiva-associated lymphoid tissue is the conjunctival equivalent to mucosa-associated lymphoid tissue (MALT). Mucosa-associated lymphoid tissue lymphoma has been shown to be associated with Helicobacter pylori. In this study, the prevalence and possible role of H. pylori infection in conjunctival MALT lymphoma were evaluated. Design: Retrospective noncomparative case series. Participants: Thirteen cases of conjunctival MALT lymphoma were investigated. Five samples of conjunctival lymphoid hyperplasia and 20 biopsies of normal conjunctiva served as controls. Methods: The specimens were investigated for the presence of H. pylori with immunohistochemistry (IHC) and nested polymerase chain reaction (PCR) techniques. For each case of conjunctival MALT lymphoma, information regarding gender, age at presentation, conjunctival localization, and information of generalized MALT lymphoma were collected. Main Outcome Measures: Detection of H. pylori and patient characteristics. Results: The 13 conjunctival MALT lymphomas originated from 8 women and 5 men with an average age of 62 years (range, 25-87). Only 1 patient had evidence of systemic MALT lymphoma. H. pylon could not be identified in any of the conjunctival MALT lymphomas, in conjunctival lymphoid hyperplasia, or in normal conjunctival biopsies using IHC and PCR techniques. Conclusions: An association between H. pylori and localized conjunctival MALT lymphoma could not be verified. Antigens other than H. pylon may take part in the development of conjunctival MALT lymphoma. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Ophthalmology
volume
114
issue
1
pages
182 - 186
publisher
Elsevier
external identifiers
  • wos:000243275300029
  • scopus:33845808774
ISSN
1549-4713
DOI
10.1016/j.ophtha.2006.09.020
language
English
LU publication?
yes
id
d3763e32-0952-4f02-bdcc-b2f34f36000e (old id 679218)
date added to LUP
2007-12-19 16:12:43
date last changed
2017-07-23 03:52:41
@article{d3763e32-0952-4f02-bdcc-b2f34f36000e,
  abstract     = {Objective: Conjunctiva-associated lymphoid tissue is the conjunctival equivalent to mucosa-associated lymphoid tissue (MALT). Mucosa-associated lymphoid tissue lymphoma has been shown to be associated with Helicobacter pylori. In this study, the prevalence and possible role of H. pylori infection in conjunctival MALT lymphoma were evaluated. Design: Retrospective noncomparative case series. Participants: Thirteen cases of conjunctival MALT lymphoma were investigated. Five samples of conjunctival lymphoid hyperplasia and 20 biopsies of normal conjunctiva served as controls. Methods: The specimens were investigated for the presence of H. pylori with immunohistochemistry (IHC) and nested polymerase chain reaction (PCR) techniques. For each case of conjunctival MALT lymphoma, information regarding gender, age at presentation, conjunctival localization, and information of generalized MALT lymphoma were collected. Main Outcome Measures: Detection of H. pylori and patient characteristics. Results: The 13 conjunctival MALT lymphomas originated from 8 women and 5 men with an average age of 62 years (range, 25-87). Only 1 patient had evidence of systemic MALT lymphoma. H. pylon could not be identified in any of the conjunctival MALT lymphomas, in conjunctival lymphoid hyperplasia, or in normal conjunctival biopsies using IHC and PCR techniques. Conclusions: An association between H. pylori and localized conjunctival MALT lymphoma could not be verified. Antigens other than H. pylon may take part in the development of conjunctival MALT lymphoma.},
  author       = {Sjo, Nicolai C. and Foegh, Pia and Juhl, Birgitte R. and Nilsson, Hans-Olof and Prause, Jan U. and Ralfkiaer, Elisabeth and Wadström, Torkel and Heegaard, Steffen},
  issn         = {1549-4713},
  language     = {eng},
  number       = {1},
  pages        = {182--186},
  publisher    = {Elsevier},
  series       = {Ophthalmology},
  title        = {Role of Helicobacter pylori in conjunctival mucosa-associated lymphoid tissue lymphoma},
  url          = {http://dx.doi.org/10.1016/j.ophtha.2006.09.020},
  volume       = {114},
  year         = {2007},
}