Foetal and neonatal alloimmune thrombocytopenia – The role of the HLA-DRB3*01:01 allele for HPA-1a-immunisation and foetal/neonatal outcome
(2020) In Transfusion and Apheresis Science 59(1).- Abstract
Foetal and neonatal alloimmune thrombocytopenia (FNAIT) is the platelet counterpart of haemolytic disease of the foetus and newborn. Among Caucasians, around 80 % of FNAIT cases and some of the most severe cases, are caused by alloantibodies against the human platelet antigen 1a (HPA-1a). For around 3 decades it has been known that almost all HPA-1a-immunised women are HLA-DRB3*01:01 positive. The HLA molecule encoded by the HLA-DRA/DRB3*01:01 genes seems to be of crucial importance for initiating the immune response against HPA-1a. The HLA-DRB3*01:01 carrier status is not only important as a risk factor for immunisation, but does also have a significant impact on foetal/neonatal outcome. The possible role of HLA-DRB3*01:01 typing as... (More)
Foetal and neonatal alloimmune thrombocytopenia (FNAIT) is the platelet counterpart of haemolytic disease of the foetus and newborn. Among Caucasians, around 80 % of FNAIT cases and some of the most severe cases, are caused by alloantibodies against the human platelet antigen 1a (HPA-1a). For around 3 decades it has been known that almost all HPA-1a-immunised women are HLA-DRB3*01:01 positive. The HLA molecule encoded by the HLA-DRA/DRB3*01:01 genes seems to be of crucial importance for initiating the immune response against HPA-1a. The HLA-DRB3*01:01 carrier status is not only important as a risk factor for immunisation, but does also have a significant impact on foetal/neonatal outcome. The possible role of HLA-DRB3*01:01 typing as tool for risk stratification is discussed.
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- author
- Kjeldsen-Kragh, Jens LU and Ahlen, Maria Therese
- organization
- publishing date
- 2020-02
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Alloimmunization, Foetus, HLA-DRB3*01:01, HPA-1a, Neonate, Platelet, Pregnancy
- in
- Transfusion and Apheresis Science
- volume
- 59
- issue
- 1
- article number
- 102707
- publisher
- Elsevier
- external identifiers
-
- scopus:85077568753
- pmid:31919011
- ISSN
- 1473-0502
- DOI
- 10.1016/j.transci.2019.102707
- language
- English
- LU publication?
- yes
- id
- 67d846a5-8037-406f-87cf-593b0cb2697a
- date added to LUP
- 2020-01-29 15:22:51
- date last changed
- 2024-07-24 13:09:16
@article{67d846a5-8037-406f-87cf-593b0cb2697a, abstract = {{<p>Foetal and neonatal alloimmune thrombocytopenia (FNAIT) is the platelet counterpart of haemolytic disease of the foetus and newborn. Among Caucasians, around 80 % of FNAIT cases and some of the most severe cases, are caused by alloantibodies against the human platelet antigen 1a (HPA-1a). For around 3 decades it has been known that almost all HPA-1a-immunised women are HLA-DRB3*01:01 positive. The HLA molecule encoded by the HLA-DRA/DRB3*01:01 genes seems to be of crucial importance for initiating the immune response against HPA-1a. The HLA-DRB3*01:01 carrier status is not only important as a risk factor for immunisation, but does also have a significant impact on foetal/neonatal outcome. The possible role of HLA-DRB3*01:01 typing as tool for risk stratification is discussed.</p>}}, author = {{Kjeldsen-Kragh, Jens and Ahlen, Maria Therese}}, issn = {{1473-0502}}, keywords = {{Alloimmunization; Foetus; HLA-DRB3*01:01; HPA-1a; Neonate; Platelet; Pregnancy}}, language = {{eng}}, number = {{1}}, publisher = {{Elsevier}}, series = {{Transfusion and Apheresis Science}}, title = {{Foetal and neonatal alloimmune thrombocytopenia – The role of the HLA-DRB3*01:01 allele for HPA-1a-immunisation and foetal/neonatal outcome}}, url = {{http://dx.doi.org/10.1016/j.transci.2019.102707}}, doi = {{10.1016/j.transci.2019.102707}}, volume = {{59}}, year = {{2020}}, }