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Foetal and neonatal alloimmune thrombocytopenia – The role of the HLA-DRB3*01:01 allele for HPA-1a-immunisation and foetal/neonatal outcome

Kjeldsen-Kragh, Jens LU and Ahlen, Maria Therese (2020) In Transfusion and Apheresis Science 59(1).
Abstract

Foetal and neonatal alloimmune thrombocytopenia (FNAIT) is the platelet counterpart of haemolytic disease of the foetus and newborn. Among Caucasians, around 80 % of FNAIT cases and some of the most severe cases, are caused by alloantibodies against the human platelet antigen 1a (HPA-1a). For around 3 decades it has been known that almost all HPA-1a-immunised women are HLA-DRB3*01:01 positive. The HLA molecule encoded by the HLA-DRA/DRB3*01:01 genes seems to be of crucial importance for initiating the immune response against HPA-1a. The HLA-DRB3*01:01 carrier status is not only important as a risk factor for immunisation, but does also have a significant impact on foetal/neonatal outcome. The possible role of HLA-DRB3*01:01 typing as... (More)

Foetal and neonatal alloimmune thrombocytopenia (FNAIT) is the platelet counterpart of haemolytic disease of the foetus and newborn. Among Caucasians, around 80 % of FNAIT cases and some of the most severe cases, are caused by alloantibodies against the human platelet antigen 1a (HPA-1a). For around 3 decades it has been known that almost all HPA-1a-immunised women are HLA-DRB3*01:01 positive. The HLA molecule encoded by the HLA-DRA/DRB3*01:01 genes seems to be of crucial importance for initiating the immune response against HPA-1a. The HLA-DRB3*01:01 carrier status is not only important as a risk factor for immunisation, but does also have a significant impact on foetal/neonatal outcome. The possible role of HLA-DRB3*01:01 typing as tool for risk stratification is discussed.

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type
Contribution to journal
publication status
published
subject
keywords
Alloimmunization, Foetus, HLA-DRB3*01:01, HPA-1a, Neonate, Platelet, Pregnancy
in
Transfusion and Apheresis Science
volume
59
issue
1
article number
102707
publisher
Elsevier
external identifiers
  • scopus:85077568753
  • pmid:31919011
ISSN
1473-0502
DOI
10.1016/j.transci.2019.102707
language
English
LU publication?
yes
id
67d846a5-8037-406f-87cf-593b0cb2697a
date added to LUP
2020-01-29 15:22:51
date last changed
2024-06-12 08:39:03
@article{67d846a5-8037-406f-87cf-593b0cb2697a,
  abstract     = {{<p>Foetal and neonatal alloimmune thrombocytopenia (FNAIT) is the platelet counterpart of haemolytic disease of the foetus and newborn. Among Caucasians, around 80 % of FNAIT cases and some of the most severe cases, are caused by alloantibodies against the human platelet antigen 1a (HPA-1a). For around 3 decades it has been known that almost all HPA-1a-immunised women are HLA-DRB3*01:01 positive. The HLA molecule encoded by the HLA-DRA/DRB3*01:01 genes seems to be of crucial importance for initiating the immune response against HPA-1a. The HLA-DRB3*01:01 carrier status is not only important as a risk factor for immunisation, but does also have a significant impact on foetal/neonatal outcome. The possible role of HLA-DRB3*01:01 typing as tool for risk stratification is discussed.</p>}},
  author       = {{Kjeldsen-Kragh, Jens and Ahlen, Maria Therese}},
  issn         = {{1473-0502}},
  keywords     = {{Alloimmunization; Foetus; HLA-DRB3*01:01; HPA-1a; Neonate; Platelet; Pregnancy}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Elsevier}},
  series       = {{Transfusion and Apheresis Science}},
  title        = {{Foetal and neonatal alloimmune thrombocytopenia – The role of the HLA-DRB3*01:01 allele for HPA-1a-immunisation and foetal/neonatal outcome}},
  url          = {{http://dx.doi.org/10.1016/j.transci.2019.102707}},
  doi          = {{10.1016/j.transci.2019.102707}},
  volume       = {{59}},
  year         = {{2020}},
}