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Detection of pre-plaque amyloid aggregation using FTIR

Klementieva, Oxana LU orcid ; Engdahl, Anders LU ; Faideau, Mathilde LU ; Willén, Katarina LU ; Uvdal, Per LU and Keppler Gouras, Gunnar LU orcid (2014) In Alzheimer's and Dementia 10(4).
Abstract
Background: Alzheimer's disease (AD) is characterized by misfolding and aggregation of naturally occurring beta-amyloid peptides (Aβ). These aggregates are thought to be pathogenic to neurons, although the conformation of the pathogenic Aβ species remains unclear. Biochemical extraction methods and different microscopy techniques (TEM, confocal) can be used to identify pathogenic Aβ species in the brain, although such methods can alter protein conformation or are n ot designed to determine structural details of protein assemblies.
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Alzheimer's and Dementia
volume
10
issue
4
publisher
Wiley
ISSN
1552-5279
DOI
10.1016/j.jalz.2014.05.1158
language
English
LU publication?
yes
id
67dea852-554e-4ca2-9a6d-070e6c291907
date added to LUP
2019-09-18 13:02:12
date last changed
2019-10-22 02:21:34
@article{67dea852-554e-4ca2-9a6d-070e6c291907,
  abstract     = {Background: Alzheimer's disease (AD) is characterized by misfolding and aggregation of naturally occurring beta-amyloid peptides (Aβ). These aggregates are thought to be pathogenic to neurons, although the conformation of the pathogenic Aβ species remains unclear. Biochemical extraction methods and different microscopy techniques (TEM, confocal) can be used to identify pathogenic Aβ species in the brain, although such methods can alter protein conformation or are n ot designed to determine structural details of protein assemblies.},
  author       = {Klementieva, Oxana and Engdahl, Anders and Faideau, Mathilde and Willén, Katarina and Uvdal, Per and Keppler Gouras, Gunnar},
  issn         = {1552-5279},
  language     = {eng},
  month        = {07},
  number       = {4},
  publisher    = {Wiley},
  series       = {Alzheimer's and Dementia},
  title        = {Detection of pre-plaque amyloid aggregation using FTIR},
  url          = {http://dx.doi.org/10.1016/j.jalz.2014.05.1158},
  doi          = {10.1016/j.jalz.2014.05.1158},
  volume       = {10},
  year         = {2014},
}