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The NF-κB modulated miR-194-5p/IGF1R/PPFIBP axis is crucial for the tumorigenesis of ovarian cancer

Bai, Ru ; Dou, Kaikai ; Wu, Yang ; Ma, Yongjing and Sun, Jianmin LU (2020) In Journal of Cancer 11(12). p.3433-3445
Abstract

miRNAs are involved in the tumorigenesis of various malignancies. In the current study, we found that miR-194-5p expression is downregulated in ovarian cancer tissues, and downregulation of miR-194-5p expression promotes proliferation, invasion and migration of human ovarian cancer cells in vitro and ovarian tumor growth in nude mice. We further found that IGF1R and PPFIBP are targets of miR-194-5p, and downregulation of miR-194-5p expression increases IGF1R and PPFIBP expression, resulting in increased proliferation, invasion and migration of ovarian cancer cells. Moreover, we showed that NF-κB can bind to the promoter region of miR-194-5p, and negatively regulate the expression of miR-194-5p in ovarian cancer cells. Taken together,... (More)

miRNAs are involved in the tumorigenesis of various malignancies. In the current study, we found that miR-194-5p expression is downregulated in ovarian cancer tissues, and downregulation of miR-194-5p expression promotes proliferation, invasion and migration of human ovarian cancer cells in vitro and ovarian tumor growth in nude mice. We further found that IGF1R and PPFIBP are targets of miR-194-5p, and downregulation of miR-194-5p expression increases IGF1R and PPFIBP expression, resulting in increased proliferation, invasion and migration of ovarian cancer cells. Moreover, we showed that NF-κB can bind to the promoter region of miR-194-5p, and negatively regulate the expression of miR-194-5p in ovarian cancer cells. Taken together, our results suggested a NF-κB modulated miR-194-5p/IGF1R/ PPFIBP axis that is crucial for the tumorigenesis of ovarian cancer, which provides a new insight into the development of ovarian cancer.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
IGF1R, MiR-194-5p, NF-κB, Ovarian cancer, PPFIBP
in
Journal of Cancer
volume
11
issue
12
pages
13 pages
publisher
Ivyspring International Publisher
external identifiers
  • scopus:85082853129
  • pmid:32284739
ISSN
1837-9664
DOI
10.7150/jca.40604
language
English
LU publication?
yes
id
67e69f2e-4546-4d8d-a6fa-a0a31597ee47
date added to LUP
2020-04-27 15:23:53
date last changed
2024-06-12 12:32:00
@article{67e69f2e-4546-4d8d-a6fa-a0a31597ee47,
  abstract     = {{<p>miRNAs are involved in the tumorigenesis of various malignancies. In the current study, we found that miR-194-5p expression is downregulated in ovarian cancer tissues, and downregulation of miR-194-5p expression promotes proliferation, invasion and migration of human ovarian cancer cells in vitro and ovarian tumor growth in nude mice. We further found that IGF1R and PPFIBP are targets of miR-194-5p, and downregulation of miR-194-5p expression increases IGF1R and PPFIBP expression, resulting in increased proliferation, invasion and migration of ovarian cancer cells. Moreover, we showed that NF-κB can bind to the promoter region of miR-194-5p, and negatively regulate the expression of miR-194-5p in ovarian cancer cells. Taken together, our results suggested a NF-κB modulated miR-194-5p/IGF1R/ PPFIBP axis that is crucial for the tumorigenesis of ovarian cancer, which provides a new insight into the development of ovarian cancer.</p>}},
  author       = {{Bai, Ru and Dou, Kaikai and Wu, Yang and Ma, Yongjing and Sun, Jianmin}},
  issn         = {{1837-9664}},
  keywords     = {{IGF1R; MiR-194-5p; NF-κB; Ovarian cancer; PPFIBP}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{12}},
  pages        = {{3433--3445}},
  publisher    = {{Ivyspring International Publisher}},
  series       = {{Journal of Cancer}},
  title        = {{The NF-κB modulated miR-194-5p/IGF1R/PPFIBP axis is crucial for the tumorigenesis of ovarian cancer}},
  url          = {{http://dx.doi.org/10.7150/jca.40604}},
  doi          = {{10.7150/jca.40604}},
  volume       = {{11}},
  year         = {{2020}},
}