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High prevalence of ischaemia, infection and serious comorbidity in patients with diabetic foot disease in Europe. Baseline results from the Eurodiale study

Prompers, L.; Huijberts, M.; Apelqvist, Jan LU ; Jude, E.; Piaggesi, A.; Bakker, K.; Edmonds, M.; Holstein, P.; Jirkovska, A. and Mauricio, D., et al. (2007) In Diabetologia 50(1). p.18-25
Abstract
Large clinical studies describing the typical clinical presentation of diabetic foot ulcers are limited and most studies were performed in single centres with the possibility of selection of specific subgroups. The aim of this study was to investigate the characteristics of diabetic patients with a foot ulcer in 14 European hospitals in ten countries. The study population included 1,229 consecutive patients presenting with a new foot ulcer between 1 September 2003 and 1 October 2004. Standardised data on patient characteristics, as well as foot and ulcer characteristics, were obtained. Foot disease was categorised into four stages according to the presence or absence of peripheral arterial disease (PAD) and infection: A: PAD -, infection... (More)
Large clinical studies describing the typical clinical presentation of diabetic foot ulcers are limited and most studies were performed in single centres with the possibility of selection of specific subgroups. The aim of this study was to investigate the characteristics of diabetic patients with a foot ulcer in 14 European hospitals in ten countries. The study population included 1,229 consecutive patients presenting with a new foot ulcer between 1 September 2003 and 1 October 2004. Standardised data on patient characteristics, as well as foot and ulcer characteristics, were obtained. Foot disease was categorised into four stages according to the presence or absence of peripheral arterial disease (PAD) and infection: A: PAD -, infection -; B: PAD -, infection +; C: PAD +, infection -; D: PAD +, infection +. PAD was diagnosed in 49% of the subjects, infection in 58%. The majority of ulcers (52%) were located on the non-plantar surface of the foot. With regard to severity, 24% had stage A, 27% had stage B, 18% had stage C and 31% had stage D foot disease. Patients in the latter group had a distinct profile: they were older, had more non-plantar ulcers, greater tissue loss and more serious comorbidity. According to our results in this European cohort, the severity of diabetic foot ulcers at presentation is greater than previously reported, as one-third had both PAD and infection. Non-plantar foot ulcers were more common than plantar ulcers, especially in patients with severe disease, and serious comorbidity increased significantly with increasing severity of foot disease. Further research is needed to obtain insight into the clinical outcome of these patients. (Less)
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Contribution to journal
publication status
published
subject
keywords
peripheral, neuropathy, multicentre, diabetes, diabetic foot ulcer, arterial disease
in
Diabetologia
volume
50
issue
1
pages
18 - 25
publisher
Springer Verlag
external identifiers
  • wos:000243188000004
  • scopus:33845957181
ISSN
1432-0428
DOI
10.1007/s00125-006-0491-1
language
English
LU publication?
yes
id
8383b130-4970-4456-b5fa-9011d6e25895 (old id 680291)
date added to LUP
2007-12-20 08:04:11
date last changed
2017-11-05 03:32:38
@article{8383b130-4970-4456-b5fa-9011d6e25895,
  abstract     = {Large clinical studies describing the typical clinical presentation of diabetic foot ulcers are limited and most studies were performed in single centres with the possibility of selection of specific subgroups. The aim of this study was to investigate the characteristics of diabetic patients with a foot ulcer in 14 European hospitals in ten countries. The study population included 1,229 consecutive patients presenting with a new foot ulcer between 1 September 2003 and 1 October 2004. Standardised data on patient characteristics, as well as foot and ulcer characteristics, were obtained. Foot disease was categorised into four stages according to the presence or absence of peripheral arterial disease (PAD) and infection: A: PAD -, infection -; B: PAD -, infection +; C: PAD +, infection -; D: PAD +, infection +. PAD was diagnosed in 49% of the subjects, infection in 58%. The majority of ulcers (52%) were located on the non-plantar surface of the foot. With regard to severity, 24% had stage A, 27% had stage B, 18% had stage C and 31% had stage D foot disease. Patients in the latter group had a distinct profile: they were older, had more non-plantar ulcers, greater tissue loss and more serious comorbidity. According to our results in this European cohort, the severity of diabetic foot ulcers at presentation is greater than previously reported, as one-third had both PAD and infection. Non-plantar foot ulcers were more common than plantar ulcers, especially in patients with severe disease, and serious comorbidity increased significantly with increasing severity of foot disease. Further research is needed to obtain insight into the clinical outcome of these patients.},
  author       = {Prompers, L. and Huijberts, M. and Apelqvist, Jan and Jude, E. and Piaggesi, A. and Bakker, K. and Edmonds, M. and Holstein, P. and Jirkovska, A. and Mauricio, D. and Ragnarson Tennvall, G and Reike, H. and Spraul, M. and Uccioli, L. and Urbancic, V. and Van Acker, K. and van Baal, J. and van Merode, F. and Schaper, N.},
  issn         = {1432-0428},
  keyword      = {peripheral,neuropathy,multicentre,diabetes,diabetic foot ulcer,arterial disease},
  language     = {eng},
  number       = {1},
  pages        = {18--25},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {High prevalence of ischaemia, infection and serious comorbidity in patients with diabetic foot disease in Europe. Baseline results from the Eurodiale study},
  url          = {http://dx.doi.org/10.1007/s00125-006-0491-1},
  volume       = {50},
  year         = {2007},
}