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Serum calcium is an independent predictor of quality of life in multiple myeloma

Wisloff, Finn; Kvam, Ann Kristin; Hjorth, Martin and Lenhoff, Stig LU (2007) In European Journal of Haematology 78(1). p.29-34
Abstract
Bone disease is an important feature of multiple myeloma, and hypercalcaemia is a frequent complication of this disease. We examined the association between serum calcium and quality of life (QOL) scores of 686 multiple myeloma patients at the time of diagnosis. Data from two Nordic studies using the EORTC QLQ-C30 questionnaire were analysed by means of linear regression analysis and a curve fitting program. Serum calcium was independently related to appetite loss, nausea/vomiting and physical functioning (P < 0.001) and to cognitive functioning (P = 0.001), i.e. scores reflecting symptoms that are well known in non-malignant hypercalcaemia. In addition, we found a highly significant independent relationship between serum calcium and... (More)
Bone disease is an important feature of multiple myeloma, and hypercalcaemia is a frequent complication of this disease. We examined the association between serum calcium and quality of life (QOL) scores of 686 multiple myeloma patients at the time of diagnosis. Data from two Nordic studies using the EORTC QLQ-C30 questionnaire were analysed by means of linear regression analysis and a curve fitting program. Serum calcium was independently related to appetite loss, nausea/vomiting and physical functioning (P < 0.001) and to cognitive functioning (P = 0.001), i.e. scores reflecting symptoms that are well known in non-malignant hypercalcaemia. In addition, we found a highly significant independent relationship between serum calcium and the scores for fatigue and pain (P < 0.001). Serum calcium appeared to be as strong a predictor for fatigue as the concentration of haemoglobin. A cubic model (y = a + bx(3)) fitted the data slightly better than the simple linear model (y = a + bx) and suggested worsening QOL scores at levels of serum calcium above 2.5-3.0 mmol/L. Hypercalcaemia in patients with multiple myeloma seems to be associated with the same symptoms as in non-malignant hypercalcaemia. In addition, an increased level of serum calcium may aggravate the pain and fatigue caused by the skeletal disease itself. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
parameters, multiple regression, disease, myeloma, hypercalcaemia, quality of life, serum calcium
in
European Journal of Haematology
volume
78
issue
1
pages
29 - 34
publisher
Wiley-Blackwell
external identifiers
  • wos:000243007100004
  • scopus:33845878815
ISSN
1600-0609
DOI
10.1111/j.0902-4441.2006.t01-1-EJH2887.x
language
English
LU publication?
yes
id
bc63e245-ecf7-4bab-9e1a-35b7fb445099 (old id 681776)
date added to LUP
2007-12-19 11:41:51
date last changed
2017-01-01 04:53:19
@article{bc63e245-ecf7-4bab-9e1a-35b7fb445099,
  abstract     = {Bone disease is an important feature of multiple myeloma, and hypercalcaemia is a frequent complication of this disease. We examined the association between serum calcium and quality of life (QOL) scores of 686 multiple myeloma patients at the time of diagnosis. Data from two Nordic studies using the EORTC QLQ-C30 questionnaire were analysed by means of linear regression analysis and a curve fitting program. Serum calcium was independently related to appetite loss, nausea/vomiting and physical functioning (P &lt; 0.001) and to cognitive functioning (P = 0.001), i.e. scores reflecting symptoms that are well known in non-malignant hypercalcaemia. In addition, we found a highly significant independent relationship between serum calcium and the scores for fatigue and pain (P &lt; 0.001). Serum calcium appeared to be as strong a predictor for fatigue as the concentration of haemoglobin. A cubic model (y = a + bx(3)) fitted the data slightly better than the simple linear model (y = a + bx) and suggested worsening QOL scores at levels of serum calcium above 2.5-3.0 mmol/L. Hypercalcaemia in patients with multiple myeloma seems to be associated with the same symptoms as in non-malignant hypercalcaemia. In addition, an increased level of serum calcium may aggravate the pain and fatigue caused by the skeletal disease itself.},
  author       = {Wisloff, Finn and Kvam, Ann Kristin and Hjorth, Martin and Lenhoff, Stig},
  issn         = {1600-0609},
  keyword      = {parameters,multiple regression,disease,myeloma,hypercalcaemia,quality of life,serum calcium},
  language     = {eng},
  number       = {1},
  pages        = {29--34},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Haematology},
  title        = {Serum calcium is an independent predictor of quality of life in multiple myeloma},
  url          = {http://dx.doi.org/10.1111/j.0902-4441.2006.t01-1-EJH2887.x},
  volume       = {78},
  year         = {2007},
}