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Nasal indices of eosinophilic and exudative inflammation in bakery-workers

Storaas, Torgeir; Ardal, Laila; Van Do, Thien; Florvaag, Erik; Steinsvag, Sverre K.; Irgens, Agot; Aasen, Tor B. and Greiff, Lennart LU (2007) In Clinical Physiology and Functional Imaging 27(1). p.23-29
Abstract
Aims: Rhinitis symptoms frequently occur in bakery-workers. Yet, little is known about the pathophysiology of this condition. The objective of the present study was to examine nasal indices of inflammation in relation to occupational dust exposure, occupational rhinitis according to defined criteria, rhinitis symptoms associated to the workplace, and occupational sensitization in bakery-workers. Methods: Bakery-workers (n = 197) were subjected to interviews, questionnaires, workplace dust measurements, allergy tests, and nasal lavages with and without histamine. alpha(2)-Macroglobulin and eosinophil cationic protein (ECP) were measured in saline lavages as indices of plasma exudation and eosinophilic activity, respectively. Histamine... (More)
Aims: Rhinitis symptoms frequently occur in bakery-workers. Yet, little is known about the pathophysiology of this condition. The objective of the present study was to examine nasal indices of inflammation in relation to occupational dust exposure, occupational rhinitis according to defined criteria, rhinitis symptoms associated to the workplace, and occupational sensitization in bakery-workers. Methods: Bakery-workers (n = 197) were subjected to interviews, questionnaires, workplace dust measurements, allergy tests, and nasal lavages with and without histamine. alpha(2)-Macroglobulin and eosinophil cationic protein (ECP) were measured in saline lavages as indices of plasma exudation and eosinophilic activity, respectively. Histamine lavages were employed to explore the nasal exudative responsiveness. Results: alpha(2)-Macroglobulin and ECP increased significantly by increased workplace dust exposure (P <= 0.035). Furthermore, the exudative responsiveness to histamine increased significantly by such exposure (P <= 0.016). Similar patterns were seen in workers with occupational rhinitis and in subjects with rhinitis symptoms associated to the workplace, but not in workers with occupational sensitization. Conclusions: We conclude that occupational dust exposure in bakery-workers is associated with nasal eosinophilic exudative inflammation. In contrast, occupational sensitization is not a discriminating factor with regard to indices of eosinophilic, exudative inflammation in the present material. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
eosinophil cationic protein, allergy, alpha(2)-macroglobulin, airway, flour, occupational rhinitis
in
Clinical Physiology and Functional Imaging
volume
27
issue
1
pages
23 - 29
publisher
Wiley Online Library
external identifiers
  • wos:000242862200005
  • scopus:33845514856
ISSN
1475-0961
DOI
10.1111/j.1475-097X.2007.00707.x
language
English
LU publication?
yes
id
7a91a006-2a8c-4a44-9610-f55c8f9ff262 (old id 681826)
date added to LUP
2007-12-20 14:01:57
date last changed
2017-01-08 03:47:03
@article{7a91a006-2a8c-4a44-9610-f55c8f9ff262,
  abstract     = {Aims: Rhinitis symptoms frequently occur in bakery-workers. Yet, little is known about the pathophysiology of this condition. The objective of the present study was to examine nasal indices of inflammation in relation to occupational dust exposure, occupational rhinitis according to defined criteria, rhinitis symptoms associated to the workplace, and occupational sensitization in bakery-workers. Methods: Bakery-workers (n = 197) were subjected to interviews, questionnaires, workplace dust measurements, allergy tests, and nasal lavages with and without histamine. alpha(2)-Macroglobulin and eosinophil cationic protein (ECP) were measured in saline lavages as indices of plasma exudation and eosinophilic activity, respectively. Histamine lavages were employed to explore the nasal exudative responsiveness. Results: alpha(2)-Macroglobulin and ECP increased significantly by increased workplace dust exposure (P &lt;= 0.035). Furthermore, the exudative responsiveness to histamine increased significantly by such exposure (P &lt;= 0.016). Similar patterns were seen in workers with occupational rhinitis and in subjects with rhinitis symptoms associated to the workplace, but not in workers with occupational sensitization. Conclusions: We conclude that occupational dust exposure in bakery-workers is associated with nasal eosinophilic exudative inflammation. In contrast, occupational sensitization is not a discriminating factor with regard to indices of eosinophilic, exudative inflammation in the present material.},
  author       = {Storaas, Torgeir and Ardal, Laila and Van Do, Thien and Florvaag, Erik and Steinsvag, Sverre K. and Irgens, Agot and Aasen, Tor B. and Greiff, Lennart},
  issn         = {1475-0961},
  keyword      = {eosinophil cationic protein,allergy,alpha(2)-macroglobulin,airway,flour,occupational rhinitis},
  language     = {eng},
  number       = {1},
  pages        = {23--29},
  publisher    = {Wiley Online Library},
  series       = {Clinical Physiology and Functional Imaging},
  title        = {Nasal indices of eosinophilic and exudative inflammation in bakery-workers},
  url          = {http://dx.doi.org/10.1111/j.1475-097X.2007.00707.x},
  volume       = {27},
  year         = {2007},
}