Moderate coffee and alcohol consumption improves the estrogen metabolite profile in adjuvant treated breast cancer patients: A pilot study comparing pre- and post-operative levels
(2006) In Molecular Genetics and Metabolism 89(4). p.381-389- Abstract
- Most, but not all, studies have found that women with a high urinary 2-hydroxyestrogen (2OHE) to 16 alpha-hydroxyestrone (16 alpha OHE1) ratio are at reduced risk for breast cancer and have a better prognosis. The aim was to identify factors associated with the pre-operative 2OHE to 16 alpha OHE1 ratio and factors that predicted the change in the ratio between the pre-operative visit and first follow-up visit three to six months post-o.peratively among 59 women with primary ER positive breast cancer tumors. Body measurements, questionnaires and blood samples for measurements of the 2OHE and 16 alpha OHE1 plasma levels and CYP1A2*1F genotyping were collected at both visits. Post-operatively, 15 women received tamoxifen, 30 women tamoxifen... (More)
- Most, but not all, studies have found that women with a high urinary 2-hydroxyestrogen (2OHE) to 16 alpha-hydroxyestrone (16 alpha OHE1) ratio are at reduced risk for breast cancer and have a better prognosis. The aim was to identify factors associated with the pre-operative 2OHE to 16 alpha OHE1 ratio and factors that predicted the change in the ratio between the pre-operative visit and first follow-up visit three to six months post-o.peratively among 59 women with primary ER positive breast cancer tumors. Body measurements, questionnaires and blood samples for measurements of the 2OHE and 16 alpha OHE1 plasma levels and CYP1A2*1F genotyping were collected at both visits. Post-operatively, 15 women received tamoxifen, 30 women tamoxifen and radiotherapy concomitantly, and 14 women radiotherapy. The pre-operative ratio was not correlated with tumor characteristics, but was significantly higher in women who consumed three or more cups of coffee daily (p = 0.009). The number of CYP1A2*1F Galleles was correlated with a lower ratio at both visits (p = 0.13 and p = 0.02, respectively). The ratio increased between the two visits in 69.5% of the women, The factors associated with a significant increase in the ratio were concomitant tamoxifen and radiotherapy (p = 0.006), increasing alcohol consumption (p = 0.006), and a high coffee consumption (p = 0.03), but not age or CYP1A2*1F genotype. In this pilot study, breast cancer patients who started tarnoxifen during radiotherapy and who had a moderate coffee and alcohol consumption demonstrated a significant improvement in their estrogen metabolite profile between the pre- and post-operative visits. (c) 2006 Elsevier Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/683589
- author
- Klug, T. L. ; Bågeman, Erika LU ; Ingvar, Christian LU ; Rose, Carsten LU and Jernström, Helena LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- alcohol, 16 alpha-hydroxyestrone, 2-hydroxyestrogen, breast cancer, tamoxifen, radiotherapy, CYP1A2, prognosis, coffee, polymorphism
- in
- Molecular Genetics and Metabolism
- volume
- 89
- issue
- 4
- pages
- 381 - 389
- publisher
- Elsevier
- external identifiers
-
- wos:000242670400012
- scopus:33750631277
- ISSN
- 1096-7192
- DOI
- 10.1016/j.ymgme.2006.08.005
- language
- English
- LU publication?
- yes
- id
- 71eb3c85-20a1-45b2-8e3e-357208dea851 (old id 683589)
- date added to LUP
- 2016-04-01 12:38:35
- date last changed
- 2022-04-21 18:16:45
@article{71eb3c85-20a1-45b2-8e3e-357208dea851,
abstract = {{Most, but not all, studies have found that women with a high urinary 2-hydroxyestrogen (2OHE) to 16 alpha-hydroxyestrone (16 alpha OHE1) ratio are at reduced risk for breast cancer and have a better prognosis. The aim was to identify factors associated with the pre-operative 2OHE to 16 alpha OHE1 ratio and factors that predicted the change in the ratio between the pre-operative visit and first follow-up visit three to six months post-o.peratively among 59 women with primary ER positive breast cancer tumors. Body measurements, questionnaires and blood samples for measurements of the 2OHE and 16 alpha OHE1 plasma levels and CYP1A2*1F genotyping were collected at both visits. Post-operatively, 15 women received tamoxifen, 30 women tamoxifen and radiotherapy concomitantly, and 14 women radiotherapy. The pre-operative ratio was not correlated with tumor characteristics, but was significantly higher in women who consumed three or more cups of coffee daily (p = 0.009). The number of CYP1A2*1F Galleles was correlated with a lower ratio at both visits (p = 0.13 and p = 0.02, respectively). The ratio increased between the two visits in 69.5% of the women, The factors associated with a significant increase in the ratio were concomitant tamoxifen and radiotherapy (p = 0.006), increasing alcohol consumption (p = 0.006), and a high coffee consumption (p = 0.03), but not age or CYP1A2*1F genotype. In this pilot study, breast cancer patients who started tarnoxifen during radiotherapy and who had a moderate coffee and alcohol consumption demonstrated a significant improvement in their estrogen metabolite profile between the pre- and post-operative visits. (c) 2006 Elsevier Inc. All rights reserved.}},
author = {{Klug, T. L. and Bågeman, Erika and Ingvar, Christian and Rose, Carsten and Jernström, Helena}},
issn = {{1096-7192}},
keywords = {{alcohol; 16 alpha-hydroxyestrone; 2-hydroxyestrogen; breast cancer; tamoxifen; radiotherapy; CYP1A2; prognosis; coffee; polymorphism}},
language = {{eng}},
number = {{4}},
pages = {{381--389}},
publisher = {{Elsevier}},
series = {{Molecular Genetics and Metabolism}},
title = {{Moderate coffee and alcohol consumption improves the estrogen metabolite profile in adjuvant treated breast cancer patients: A pilot study comparing pre- and post-operative levels}},
url = {{http://dx.doi.org/10.1016/j.ymgme.2006.08.005}},
doi = {{10.1016/j.ymgme.2006.08.005}},
volume = {{89}},
year = {{2006}},
}