Patch testing with components of water-based metalworking fluids: results of a multicentre study with a second series
(2006) In Contact Dermatitis 55(6). p.322-329- Abstract
- Background: Although many allergens in metalworking fluids (MWF) are identified, there are still some MWF components, which are not sufficiently investigated concerning their sensitizing properties. Objectives: To investigate sensitization to 10 frequently used MWF components, which are not part of the established MWF test series, in metalworkers with suspected occupational dermatitis due to MWF. Patients/Methods: Oleyl alcohol, myristyl alcohol, dimethylolurea, 4,4'-methylenebis morpholine, imazalil, 1-amino-2-propanol (monoisopropanolamine; MIPA), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2,5-bis(n-octyldithio)-1,3,4-thiadiazole, zinc alkyl dithiophosphate and dibenzyl disulfide have been patch tested in 144 patients. Results: 7 patients... (More)
- Background: Although many allergens in metalworking fluids (MWF) are identified, there are still some MWF components, which are not sufficiently investigated concerning their sensitizing properties. Objectives: To investigate sensitization to 10 frequently used MWF components, which are not part of the established MWF test series, in metalworkers with suspected occupational dermatitis due to MWF. Patients/Methods: Oleyl alcohol, myristyl alcohol, dimethylolurea, 4,4'-methylenebis morpholine, imazalil, 1-amino-2-propanol (monoisopropanolamine; MIPA), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2,5-bis(n-octyldithio)-1,3,4-thiadiazole, zinc alkyl dithiophosphate and dibenzyl disulfide have been patch tested in 144 patients. Results: 7 patients reacted positively to the formaldehyde releaser 4,4'-methylenebis morpholine, and 6 of these patients also reacted to formaldehyde and/or other formaldehyde releasers. 4 patients reacted positively to myristyl alcohol tested at 10% petrolatum (pet.). Additionally, 20 doubtful or irritant reactions occurred. 1 patient each reacted positively to oleyl alcohol, MIRA, and AEPD. None of the other test substances mentioned above elicited any clear-cut positive reaction. Patch testing with well-known MWF allergens showed proportions of positive reactions, which were comparable to those from other studies, e.g. 11% to monoethanolamine, 8% to colophonium and 3%-5% to various preservatives. Conclusions: 4,4'-methylenebis morpholine may be an important MWF allergen, although clinical relevance could not be stated definitely in every case. Myristyl alcohol should not be patch tested at 10% pet., but at a lesser concentration, due to irritant properties. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/685298
- author
- Geier, Johannes ; Lessmann, Holger ; Becker, Detlef ; Bruze, Magnus LU ; Frosch, Peter J. ; Fuchs, Thomas ; Jappe, Uta ; Koch, Patrick ; Pfoehler, Claudia and Skudlik, Christoph
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 4, metalworking fluids, formaldehyde, contact allergy, MIPA), (monoisopropanolamine, 3-propanediol (AEPD), 2-amino-2-ethyl-1, 1-amino-2-propanol, 4 '-methylenebis morpholine, myristyl alcohol, occupational, patch testing
- in
- Contact Dermatitis
- volume
- 55
- issue
- 6
- pages
- 322 - 329
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000242532300002
- scopus:33750895891
- pmid:17101005
- ISSN
- 0105-1873
- DOI
- 10.1111/j.1600-0536.2006.00993.x
- language
- English
- LU publication?
- yes
- id
- cde369da-e8c6-4f51-98a5-1e467dded59e (old id 685298)
- date added to LUP
- 2016-04-01 12:25:35
- date last changed
- 2022-01-27 03:33:02
@article{cde369da-e8c6-4f51-98a5-1e467dded59e,
abstract = {{Background: Although many allergens in metalworking fluids (MWF) are identified, there are still some MWF components, which are not sufficiently investigated concerning their sensitizing properties. Objectives: To investigate sensitization to 10 frequently used MWF components, which are not part of the established MWF test series, in metalworkers with suspected occupational dermatitis due to MWF. Patients/Methods: Oleyl alcohol, myristyl alcohol, dimethylolurea, 4,4'-methylenebis morpholine, imazalil, 1-amino-2-propanol (monoisopropanolamine; MIPA), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2,5-bis(n-octyldithio)-1,3,4-thiadiazole, zinc alkyl dithiophosphate and dibenzyl disulfide have been patch tested in 144 patients. Results: 7 patients reacted positively to the formaldehyde releaser 4,4'-methylenebis morpholine, and 6 of these patients also reacted to formaldehyde and/or other formaldehyde releasers. 4 patients reacted positively to myristyl alcohol tested at 10% petrolatum (pet.). Additionally, 20 doubtful or irritant reactions occurred. 1 patient each reacted positively to oleyl alcohol, MIRA, and AEPD. None of the other test substances mentioned above elicited any clear-cut positive reaction. Patch testing with well-known MWF allergens showed proportions of positive reactions, which were comparable to those from other studies, e.g. 11% to monoethanolamine, 8% to colophonium and 3%-5% to various preservatives. Conclusions: 4,4'-methylenebis morpholine may be an important MWF allergen, although clinical relevance could not be stated definitely in every case. Myristyl alcohol should not be patch tested at 10% pet., but at a lesser concentration, due to irritant properties.}},
author = {{Geier, Johannes and Lessmann, Holger and Becker, Detlef and Bruze, Magnus and Frosch, Peter J. and Fuchs, Thomas and Jappe, Uta and Koch, Patrick and Pfoehler, Claudia and Skudlik, Christoph}},
issn = {{0105-1873}},
keywords = {{4; metalworking fluids; formaldehyde; contact allergy; MIPA); (monoisopropanolamine; 3-propanediol (AEPD); 2-amino-2-ethyl-1; 1-amino-2-propanol; 4 '-methylenebis morpholine; myristyl alcohol; occupational; patch testing}},
language = {{eng}},
number = {{6}},
pages = {{322--329}},
publisher = {{Wiley-Blackwell}},
series = {{Contact Dermatitis}},
title = {{Patch testing with components of water-based metalworking fluids: results of a multicentre study with a second series}},
url = {{http://dx.doi.org/10.1111/j.1600-0536.2006.00993.x}},
doi = {{10.1111/j.1600-0536.2006.00993.x}},
volume = {{55}},
year = {{2006}},
}