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Patch testing with components of water-based metalworking fluids: results of a multicentre study with a second series

Geier, Johannes ; Lessmann, Holger ; Becker, Detlef ; Bruze, Magnus LU ; Frosch, Peter J. ; Fuchs, Thomas ; Jappe, Uta ; Koch, Patrick ; Pfoehler, Claudia and Skudlik, Christoph (2006) In Contact Dermatitis 55(6). p.322-329
Abstract
Background: Although many allergens in metalworking fluids (MWF) are identified, there are still some MWF components, which are not sufficiently investigated concerning their sensitizing properties. Objectives: To investigate sensitization to 10 frequently used MWF components, which are not part of the established MWF test series, in metalworkers with suspected occupational dermatitis due to MWF. Patients/Methods: Oleyl alcohol, myristyl alcohol, dimethylolurea, 4,4'-methylenebis morpholine, imazalil, 1-amino-2-propanol (monoisopropanolamine; MIPA), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2,5-bis(n-octyldithio)-1,3,4-thiadiazole, zinc alkyl dithiophosphate and dibenzyl disulfide have been patch tested in 144 patients. Results: 7 patients... (More)
Background: Although many allergens in metalworking fluids (MWF) are identified, there are still some MWF components, which are not sufficiently investigated concerning their sensitizing properties. Objectives: To investigate sensitization to 10 frequently used MWF components, which are not part of the established MWF test series, in metalworkers with suspected occupational dermatitis due to MWF. Patients/Methods: Oleyl alcohol, myristyl alcohol, dimethylolurea, 4,4'-methylenebis morpholine, imazalil, 1-amino-2-propanol (monoisopropanolamine; MIPA), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2,5-bis(n-octyldithio)-1,3,4-thiadiazole, zinc alkyl dithiophosphate and dibenzyl disulfide have been patch tested in 144 patients. Results: 7 patients reacted positively to the formaldehyde releaser 4,4'-methylenebis morpholine, and 6 of these patients also reacted to formaldehyde and/or other formaldehyde releasers. 4 patients reacted positively to myristyl alcohol tested at 10% petrolatum (pet.). Additionally, 20 doubtful or irritant reactions occurred. 1 patient each reacted positively to oleyl alcohol, MIRA, and AEPD. None of the other test substances mentioned above elicited any clear-cut positive reaction. Patch testing with well-known MWF allergens showed proportions of positive reactions, which were comparable to those from other studies, e.g. 11% to monoethanolamine, 8% to colophonium and 3%-5% to various preservatives. Conclusions: 4,4'-methylenebis morpholine may be an important MWF allergen, although clinical relevance could not be stated definitely in every case. Myristyl alcohol should not be patch tested at 10% pet., but at a lesser concentration, due to irritant properties. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
4, metalworking fluids, formaldehyde, contact allergy, MIPA), (monoisopropanolamine, 3-propanediol (AEPD), 2-amino-2-ethyl-1, 1-amino-2-propanol, 4 '-methylenebis morpholine, myristyl alcohol, occupational, patch testing
in
Contact Dermatitis
volume
55
issue
6
pages
322 - 329
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000242532300002
  • scopus:33750895891
  • pmid:17101005
ISSN
0105-1873
DOI
10.1111/j.1600-0536.2006.00993.x
language
English
LU publication?
yes
id
cde369da-e8c6-4f51-98a5-1e467dded59e (old id 685298)
date added to LUP
2016-04-01 12:25:35
date last changed
2020-10-20 03:43:34
@article{cde369da-e8c6-4f51-98a5-1e467dded59e,
  abstract     = {Background: Although many allergens in metalworking fluids (MWF) are identified, there are still some MWF components, which are not sufficiently investigated concerning their sensitizing properties. Objectives: To investigate sensitization to 10 frequently used MWF components, which are not part of the established MWF test series, in metalworkers with suspected occupational dermatitis due to MWF. Patients/Methods: Oleyl alcohol, myristyl alcohol, dimethylolurea, 4,4'-methylenebis morpholine, imazalil, 1-amino-2-propanol (monoisopropanolamine; MIPA), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2,5-bis(n-octyldithio)-1,3,4-thiadiazole, zinc alkyl dithiophosphate and dibenzyl disulfide have been patch tested in 144 patients. Results: 7 patients reacted positively to the formaldehyde releaser 4,4'-methylenebis morpholine, and 6 of these patients also reacted to formaldehyde and/or other formaldehyde releasers. 4 patients reacted positively to myristyl alcohol tested at 10% petrolatum (pet.). Additionally, 20 doubtful or irritant reactions occurred. 1 patient each reacted positively to oleyl alcohol, MIRA, and AEPD. None of the other test substances mentioned above elicited any clear-cut positive reaction. Patch testing with well-known MWF allergens showed proportions of positive reactions, which were comparable to those from other studies, e.g. 11% to monoethanolamine, 8% to colophonium and 3%-5% to various preservatives. Conclusions: 4,4'-methylenebis morpholine may be an important MWF allergen, although clinical relevance could not be stated definitely in every case. Myristyl alcohol should not be patch tested at 10% pet., but at a lesser concentration, due to irritant properties.},
  author       = {Geier, Johannes and Lessmann, Holger and Becker, Detlef and Bruze, Magnus and Frosch, Peter J. and Fuchs, Thomas and Jappe, Uta and Koch, Patrick and Pfoehler, Claudia and Skudlik, Christoph},
  issn         = {0105-1873},
  language     = {eng},
  number       = {6},
  pages        = {322--329},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Patch testing with components of water-based metalworking fluids: results of a multicentre study with a second series},
  url          = {http://dx.doi.org/10.1111/j.1600-0536.2006.00993.x},
  doi          = {10.1111/j.1600-0536.2006.00993.x},
  volume       = {55},
  year         = {2006},
}