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Effects of Ischemia-Reperfusion Injury on Apolipoprotein M Expression in the Liver

Xu, X. ; Ye, Q. ; Xu, Ning LU ; He, X. ; Luo, G. ; Zhang, X. ; Zhu, J. ; Zhang, Y. and Nilsson-Ehle, Peter LU (2006) In Transplantation Proceedings 38(9). p.2769-2773
Abstract
The present study investigated the expression pattern of apolipoprotein M (apoM) mRNA in a rat model of hepatic ischemia-reperfusion injury (IRI). Animals were ischemic for I hour followed by various reperfusion times. As expected, serum alanine aminotransferase levels were significantly increased under IRI, which indicated the severity of liver injury. Hepatic mRNA levels of HSP70, which is the most common characterized protein within the family of heat-shock proteins (HSP), were significantly increased after 0.5 to 3 hours of IRI. Plasma Greactive protein, high-density lipoprotein-cholesterol, and lipoprotein (a) levels were significantly increased after 1-hour ischemia followed by 0.5 to 3 hours of reperfusion. Interestingly, similar to... (More)
The present study investigated the expression pattern of apolipoprotein M (apoM) mRNA in a rat model of hepatic ischemia-reperfusion injury (IRI). Animals were ischemic for I hour followed by various reperfusion times. As expected, serum alanine aminotransferase levels were significantly increased under IRI, which indicated the severity of liver injury. Hepatic mRNA levels of HSP70, which is the most common characterized protein within the family of heat-shock proteins (HSP), were significantly increased after 0.5 to 3 hours of IRI. Plasma Greactive protein, high-density lipoprotein-cholesterol, and lipoprotein (a) levels were significantly increased after 1-hour ischemia followed by 0.5 to 3 hours of reperfusion. Interestingly, similar to HSP70, apoM mRNA levels in the liver were gradually increased after 0.5 to 3 hours of IRI, whereas it returned to a lower level after 6 or 24 hours of IRI, which indicated that hepatic apoM expression was significantly influenced by the acute phase of IRI. However, plasma apoM levels were not increased in parallel, even slightly decreasing after 0.5 or I hour of IRI. We concluded that apoM mRNA expression pattern, like HSP70, in the liver showed rapid, significant changes during hepatic local IRI. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Transplantation Proceedings
volume
38
issue
9
pages
2769 - 2773
publisher
Elsevier
external identifiers
  • wos:000242294500006
  • scopus:33750964505
  • pmid:17112825
ISSN
0041-1345
DOI
10.1016/j.transproceed.2006.08.133
language
English
LU publication?
yes
id
f8648469-749c-48c8-9ef3-617d69cf3712 (old id 685388)
date added to LUP
2016-04-01 12:22:31
date last changed
2020-11-10 01:17:49
@article{f8648469-749c-48c8-9ef3-617d69cf3712,
  abstract     = {The present study investigated the expression pattern of apolipoprotein M (apoM) mRNA in a rat model of hepatic ischemia-reperfusion injury (IRI). Animals were ischemic for I hour followed by various reperfusion times. As expected, serum alanine aminotransferase levels were significantly increased under IRI, which indicated the severity of liver injury. Hepatic mRNA levels of HSP70, which is the most common characterized protein within the family of heat-shock proteins (HSP), were significantly increased after 0.5 to 3 hours of IRI. Plasma Greactive protein, high-density lipoprotein-cholesterol, and lipoprotein (a) levels were significantly increased after 1-hour ischemia followed by 0.5 to 3 hours of reperfusion. Interestingly, similar to HSP70, apoM mRNA levels in the liver were gradually increased after 0.5 to 3 hours of IRI, whereas it returned to a lower level after 6 or 24 hours of IRI, which indicated that hepatic apoM expression was significantly influenced by the acute phase of IRI. However, plasma apoM levels were not increased in parallel, even slightly decreasing after 0.5 or I hour of IRI. We concluded that apoM mRNA expression pattern, like HSP70, in the liver showed rapid, significant changes during hepatic local IRI.},
  author       = {Xu, X. and Ye, Q. and Xu, Ning and He, X. and Luo, G. and Zhang, X. and Zhu, J. and Zhang, Y. and Nilsson-Ehle, Peter},
  issn         = {0041-1345},
  language     = {eng},
  number       = {9},
  pages        = {2769--2773},
  publisher    = {Elsevier},
  series       = {Transplantation Proceedings},
  title        = {Effects of Ischemia-Reperfusion Injury on Apolipoprotein M Expression in the Liver},
  url          = {http://dx.doi.org/10.1016/j.transproceed.2006.08.133},
  doi          = {10.1016/j.transproceed.2006.08.133},
  volume       = {38},
  year         = {2006},
}