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Under what conditions is feedback microwave thermotherapy (ProstaLund Feedback Treatment) cost-effective in comparison with alpha-blockade in the treatment of benign prostatic hyperplasia and lower urinary tract symptoms?

Tennvall, Gunnel Ragnarson ; Hjelmgren, Jonas and Malmberg, Lars LU (2006) In Scandinavian Journal of Urology and Nephrology 40(6). p.495-505
Abstract
Objective. Lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) are a common condition in men, and their incidence increases with age. The objective of this study was to evaluate the potential cost-utility of microwave thermotherapy, specifically the ProstaLund Feedback Treatment (PLFT), versus alpha-blockade in Swedish patients with LUTS due to BPH. Material and methods. A health-economic simulation model, based on long-term disease progression and costs, was developed to analyse the cost-utility of PLFT in comparison with alpha-blockade over a 3-year period based on data from published literature, treatment programmes and official price lists. Outcome measures used in the analysis were quality of life, survival... (More)
Objective. Lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) are a common condition in men, and their incidence increases with age. The objective of this study was to evaluate the potential cost-utility of microwave thermotherapy, specifically the ProstaLund Feedback Treatment (PLFT), versus alpha-blockade in Swedish patients with LUTS due to BPH. Material and methods. A health-economic simulation model, based on long-term disease progression and costs, was developed to analyse the cost-utility of PLFT in comparison with alpha-blockade over a 3-year period based on data from published literature, treatment programmes and official price lists. Outcome measures used in the analysis were quality of life, survival and reduction in International Prostate Symptom Score. Sensitivity analyses were performed for a number of essential variables. The perspective of the study is the healthcare sector. All costs are expressed as 2003 prices. Results. Three years after an intervention with PLFT or initiation of drug treatment the cost-utility of PLFT was estimated at approximate to euro6600-9500 per quality-adjusted life-year gained. The cost-utility was further improved over a longer time period, and PLFT appears to be cost-saving after 5 years. One important finding from the model simulation was that PLFT also seems to be favourable in patients with less pronounced symptoms. This result may be further validated when additional results from controlled clinical trials become available. Conclusions. The present model simulation indicates that treatment with PLFT seems to be cost-effective compared with drug therapy with alpha-blockade. The result shows that the time-frame of the analysis has a great impact on the cost-effectiveness ratio. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
transurethral microwave thermotherapy, cost-utility, adrenergic alpha-antagonists, benign prostatic hyperplasia, quality of life
in
Scandinavian Journal of Urology and Nephrology
volume
40
issue
6
pages
495 - 505
publisher
Taylor & Francis
external identifiers
  • wos:000242333000008
  • scopus:33751569902
ISSN
0036-5599
DOI
10.1080/00365590600830409
language
English
LU publication?
yes
id
7f94c23d-171c-4687-8754-7cd6fdd7ea5d (old id 685401)
date added to LUP
2016-04-01 15:30:31
date last changed
2021-02-17 05:32:41
@article{7f94c23d-171c-4687-8754-7cd6fdd7ea5d,
  abstract     = {Objective. Lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) are a common condition in men, and their incidence increases with age. The objective of this study was to evaluate the potential cost-utility of microwave thermotherapy, specifically the ProstaLund Feedback Treatment (PLFT), versus alpha-blockade in Swedish patients with LUTS due to BPH. Material and methods. A health-economic simulation model, based on long-term disease progression and costs, was developed to analyse the cost-utility of PLFT in comparison with alpha-blockade over a 3-year period based on data from published literature, treatment programmes and official price lists. Outcome measures used in the analysis were quality of life, survival and reduction in International Prostate Symptom Score. Sensitivity analyses were performed for a number of essential variables. The perspective of the study is the healthcare sector. All costs are expressed as 2003 prices. Results. Three years after an intervention with PLFT or initiation of drug treatment the cost-utility of PLFT was estimated at approximate to euro6600-9500 per quality-adjusted life-year gained. The cost-utility was further improved over a longer time period, and PLFT appears to be cost-saving after 5 years. One important finding from the model simulation was that PLFT also seems to be favourable in patients with less pronounced symptoms. This result may be further validated when additional results from controlled clinical trials become available. Conclusions. The present model simulation indicates that treatment with PLFT seems to be cost-effective compared with drug therapy with alpha-blockade. The result shows that the time-frame of the analysis has a great impact on the cost-effectiveness ratio.},
  author       = {Tennvall, Gunnel Ragnarson and Hjelmgren, Jonas and Malmberg, Lars},
  issn         = {0036-5599},
  language     = {eng},
  number       = {6},
  pages        = {495--505},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Urology and Nephrology},
  title        = {Under what conditions is feedback microwave thermotherapy (ProstaLund Feedback Treatment) cost-effective in comparison with alpha-blockade in the treatment of benign prostatic hyperplasia and lower urinary tract symptoms?},
  url          = {http://dx.doi.org/10.1080/00365590600830409},
  doi          = {10.1080/00365590600830409},
  volume       = {40},
  year         = {2006},
}