Inhibition of carcinoma cell-derived VEGF reduces inflammatory characteristics in xenograft carcinoma
(2006) In International Journal of Cancer 119(12). p.2795-2802- Abstract
- The stroma of carcinomas shares several characteristics with inflamed tissues including a distorted vasculature, active angiogenesis and macrophage infiltration. In addition, the tumor interstitial fluid pressure (P-IF) of the stroma is pathologically elevated. We show here that bevacizumab [rhuMab vascular endothelial growth factor (VEGF), Avastin], a monoclonal antibody to VEGF, at a dose of 5 mg/kg modulated inflammation in KAT-4 xenograft human anaplastic thyroid carcinoma tissue. At this dose, bevacizumab reduced the density of macrophages, MHC class II antigen expression by macrophages and II-1 beta mRNA expression. Furthermore, bevacizumab lowered tumor extracellular fluid volume, plasma protein leakage from tumor vessels, the... (More)
- The stroma of carcinomas shares several characteristics with inflamed tissues including a distorted vasculature, active angiogenesis and macrophage infiltration. In addition, the tumor interstitial fluid pressure (P-IF) of the stroma is pathologically elevated. We show here that bevacizumab [rhuMab vascular endothelial growth factor (VEGF), Avastin], a monoclonal antibody to VEGF, at a dose of 5 mg/kg modulated inflammation in KAT-4 xenograft human anaplastic thyroid carcinoma tissue. At this dose, bevacizumab reduced the density of macrophages, MHC class II antigen expression by macrophages and II-1 beta mRNA expression. Furthermore, bevacizumab lowered tumor extracellular fluid volume, plasma protein leakage from tumor vessels, the number of CD31positive structures and tumor P-IF. The tumor plasma volume and the number of alpha-smooth muscle actin-positive vessels, however, remained unchanged. Our data suggest that carcinoma cellderived VEGF either directly or indirectly participates in maintaining an inflammatory microenvironment in experimental KAT4 carcinoma. Furthermore, our data indicate that the reduction of inflammation resulting in reduced vascular permeability and decrease in the tumor extracellular fluid volume by bevacizurnab contributes to reduced tumor P-IF. (c) 2006 Wiley-Liss, Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/685511
- author
- Salnikov, Alexei LU ; Heldin, Nils-Erik ; Stuhr, Linda B. ; Wiig, Helge ; Gerber, Hanspeter ; Reed, Rolf K. and Rubin, Kristofer
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- vasculature, interstitial fluid pressure, growth factors, angiogenesis, anaplastic thyroid carcinoma
- in
- International Journal of Cancer
- volume
- 119
- issue
- 12
- pages
- 2795 - 2802
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000242307800010
- scopus:33751579930
- ISSN
- 0020-7136
- DOI
- 10.1002/ijc.22217
- language
- English
- LU publication?
- yes
- id
- 4743c976-ded8-4d92-a4aa-d254cade1e9e (old id 685511)
- date added to LUP
- 2016-04-01 11:50:35
- date last changed
- 2022-01-26 19:03:32
@article{4743c976-ded8-4d92-a4aa-d254cade1e9e,
abstract = {{The stroma of carcinomas shares several characteristics with inflamed tissues including a distorted vasculature, active angiogenesis and macrophage infiltration. In addition, the tumor interstitial fluid pressure (P-IF) of the stroma is pathologically elevated. We show here that bevacizumab [rhuMab vascular endothelial growth factor (VEGF), Avastin], a monoclonal antibody to VEGF, at a dose of 5 mg/kg modulated inflammation in KAT-4 xenograft human anaplastic thyroid carcinoma tissue. At this dose, bevacizumab reduced the density of macrophages, MHC class II antigen expression by macrophages and II-1 beta mRNA expression. Furthermore, bevacizumab lowered tumor extracellular fluid volume, plasma protein leakage from tumor vessels, the number of CD31positive structures and tumor P-IF. The tumor plasma volume and the number of alpha-smooth muscle actin-positive vessels, however, remained unchanged. Our data suggest that carcinoma cellderived VEGF either directly or indirectly participates in maintaining an inflammatory microenvironment in experimental KAT4 carcinoma. Furthermore, our data indicate that the reduction of inflammation resulting in reduced vascular permeability and decrease in the tumor extracellular fluid volume by bevacizurnab contributes to reduced tumor P-IF. (c) 2006 Wiley-Liss, Inc.}},
author = {{Salnikov, Alexei and Heldin, Nils-Erik and Stuhr, Linda B. and Wiig, Helge and Gerber, Hanspeter and Reed, Rolf K. and Rubin, Kristofer}},
issn = {{0020-7136}},
keywords = {{vasculature; interstitial fluid pressure; growth factors; angiogenesis; anaplastic thyroid carcinoma}},
language = {{eng}},
number = {{12}},
pages = {{2795--2802}},
publisher = {{John Wiley & Sons Inc.}},
series = {{International Journal of Cancer}},
title = {{Inhibition of carcinoma cell-derived VEGF reduces inflammatory characteristics in xenograft carcinoma}},
url = {{http://dx.doi.org/10.1002/ijc.22217}},
doi = {{10.1002/ijc.22217}},
volume = {{119}},
year = {{2006}},
}