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Inhibition of carcinoma cell-derived VEGF reduces inflammatory characteristics in xenograft carcinoma

Salnikov, Alexei LU ; Heldin, Nils-Erik ; Stuhr, Linda B. ; Wiig, Helge ; Gerber, Hanspeter ; Reed, Rolf K. and Rubin, Kristofer (2006) In International Journal of Cancer 119(12). p.2795-2802
Abstract
The stroma of carcinomas shares several characteristics with inflamed tissues including a distorted vasculature, active angiogenesis and macrophage infiltration. In addition, the tumor interstitial fluid pressure (P-IF) of the stroma is pathologically elevated. We show here that bevacizumab [rhuMab vascular endothelial growth factor (VEGF), Avastin], a monoclonal antibody to VEGF, at a dose of 5 mg/kg modulated inflammation in KAT-4 xenograft human anaplastic thyroid carcinoma tissue. At this dose, bevacizumab reduced the density of macrophages, MHC class II antigen expression by macrophages and II-1 beta mRNA expression. Furthermore, bevacizumab lowered tumor extracellular fluid volume, plasma protein leakage from tumor vessels, the... (More)
The stroma of carcinomas shares several characteristics with inflamed tissues including a distorted vasculature, active angiogenesis and macrophage infiltration. In addition, the tumor interstitial fluid pressure (P-IF) of the stroma is pathologically elevated. We show here that bevacizumab [rhuMab vascular endothelial growth factor (VEGF), Avastin], a monoclonal antibody to VEGF, at a dose of 5 mg/kg modulated inflammation in KAT-4 xenograft human anaplastic thyroid carcinoma tissue. At this dose, bevacizumab reduced the density of macrophages, MHC class II antigen expression by macrophages and II-1 beta mRNA expression. Furthermore, bevacizumab lowered tumor extracellular fluid volume, plasma protein leakage from tumor vessels, the number of CD31positive structures and tumor P-IF. The tumor plasma volume and the number of alpha-smooth muscle actin-positive vessels, however, remained unchanged. Our data suggest that carcinoma cellderived VEGF either directly or indirectly participates in maintaining an inflammatory microenvironment in experimental KAT4 carcinoma. Furthermore, our data indicate that the reduction of inflammation resulting in reduced vascular permeability and decrease in the tumor extracellular fluid volume by bevacizurnab contributes to reduced tumor P-IF. (c) 2006 Wiley-Liss, Inc. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
vasculature, interstitial fluid pressure, growth factors, angiogenesis, anaplastic thyroid carcinoma
in
International Journal of Cancer
volume
119
issue
12
pages
2795 - 2802
publisher
John Wiley and Sons
external identifiers
  • wos:000242307800010
  • scopus:33751579930
ISSN
0020-7136
DOI
10.1002/ijc.22217
language
English
LU publication?
yes
id
4743c976-ded8-4d92-a4aa-d254cade1e9e (old id 685511)
date added to LUP
2016-04-01 11:50:35
date last changed
2021-10-03 05:25:21
@article{4743c976-ded8-4d92-a4aa-d254cade1e9e,
  abstract     = {The stroma of carcinomas shares several characteristics with inflamed tissues including a distorted vasculature, active angiogenesis and macrophage infiltration. In addition, the tumor interstitial fluid pressure (P-IF) of the stroma is pathologically elevated. We show here that bevacizumab [rhuMab vascular endothelial growth factor (VEGF), Avastin], a monoclonal antibody to VEGF, at a dose of 5 mg/kg modulated inflammation in KAT-4 xenograft human anaplastic thyroid carcinoma tissue. At this dose, bevacizumab reduced the density of macrophages, MHC class II antigen expression by macrophages and II-1 beta mRNA expression. Furthermore, bevacizumab lowered tumor extracellular fluid volume, plasma protein leakage from tumor vessels, the number of CD31positive structures and tumor P-IF. The tumor plasma volume and the number of alpha-smooth muscle actin-positive vessels, however, remained unchanged. Our data suggest that carcinoma cellderived VEGF either directly or indirectly participates in maintaining an inflammatory microenvironment in experimental KAT4 carcinoma. Furthermore, our data indicate that the reduction of inflammation resulting in reduced vascular permeability and decrease in the tumor extracellular fluid volume by bevacizurnab contributes to reduced tumor P-IF. (c) 2006 Wiley-Liss, Inc.},
  author       = {Salnikov, Alexei and Heldin, Nils-Erik and Stuhr, Linda B. and Wiig, Helge and Gerber, Hanspeter and Reed, Rolf K. and Rubin, Kristofer},
  issn         = {0020-7136},
  language     = {eng},
  number       = {12},
  pages        = {2795--2802},
  publisher    = {John Wiley and Sons},
  series       = {International Journal of Cancer},
  title        = {Inhibition of carcinoma cell-derived VEGF reduces inflammatory characteristics in xenograft carcinoma},
  url          = {http://dx.doi.org/10.1002/ijc.22217},
  doi          = {10.1002/ijc.22217},
  volume       = {119},
  year         = {2006},
}